ISSN:
1434-9949
Keywords:
VLA-4 Antigen
;
Systemic Lups Erythematosus
;
Necrotizing Vasculitis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We report on a patient (S.A.), with well-defind SLE who developed a perforation of the ileum due to pathologically confirmed necrotizing vasculitis. No anti-DNA antibody was detected at the ileal perforation, and the serum complement level was normal. These findings rais ethe alternative possibility of a cellmediated immune mechanism as a cause of necrotizing vaculitis. Upregulateed expression and function of VLA-4 antigen on peripheral blood T cells were oberved, suggesting that T cells with VLA-4 antigen may participate in the onset and/or perpetuation of vascular inflammation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02208357
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