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  • 1
    Electronic Resource
    Electronic Resource
    Bildung, Kristallstruktur und absolute Konfiguration von (-)-N-(Chloromethyl)galanthaminium-chlorid (1994)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 77 (1994), S. 1611-1615 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Formation, X-Ray Crystal Structure, and Absolute Configuration of (-)-N-(Chloromethyl)galanthaminium ChlorideThe acetylcholinesterase inhibitor galanthamine (1), main alkaloid of several Narcissus species, readily forms a quaternary ammonium salt by reaction with the solvent CH2Cl2. The structure and absolute configuration of (-)-N-(chloromethyl)galanthaminium chloride (2) were determined by X-ray diffraction (R = 0.075 for 2775 observed independent reflexions) and NMR spectroscopy. The tetragonal crystals (space group P43) contain two crystallographically independent cations which do not differ significantly from one another. The CH2Cl group is attached to the quaternary N-atom in stereospecific (R)-configuration. In the crystal, the configurational position of the Me group at the N-atom of 2 differs from that of the crystalline free base 1. Hydrogen bonding is observed from the OH group at C(3) of 2 to the Cl- anion or to the Cl-atom of an adjacent cation.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19940770617
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  • 2
    Electronic Resource
    Electronic Resource
    über die Bildung einer Rubazonsäure aus Phenylhydrazinderivaten der Zucker (1961)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 648 (1961), S. 96-113 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Einwirkung von Perjodat auf Dextran, Xylan, Inulin und Saccharose führt zu Oxydationsprodukten dieser Zucker, die mit Phenylhydrazin unter anderem Abkömmlinge der Rubazonsäure ergeben.  -  Die gleichen Verbindungen entstehen bei Einwirkung von asymmetrisch disubstituierten Arylhydrazinen auf D-Fructoson-1-phenylhydrazon oder auf Glycerose-phenylosazon und durch Umsetzung von Glycerinaldehyd-methylphenylhydrazon mit Phenylhydrazin. Es wird über Synthese und Eigenschaften dieser Verbindungen berichtet.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19616480114
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Intramolekulare Addition von Carbanionen an Anthrachinone (1984)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1984 (1984), S. 306-318 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Intramoleclar Addition of Carbanions to AnthraquinonesThe intramolecular Michael addition of the carbanions derived from the β-keto diesters 15a and 15b yields the naphthacenequinones 20a and 20b. In contrast, the similar dimethyl ether 11 cyclizes to give the benzo[α]anthracenequinone 17. The hydroquinone of 1,8-dihydroxyanthraquinone (5a) reacts with acrylate to yield the unusual anthrone derivatives 12b and 12c.
    Notes: Die intramolekulare Michael-Addition der Carbanionen, die sich von den β-Ketodiestern 15a und 15b ableiten, liefert die Naphthacenchinone 20a und 20b. Dagegen cyclisiert der Dimethylether 11 zum Benzo[α]anthracenchinon 17. Das Hydrochinon des 1,8-Dihydroxyanthrachinons (5a) reagiert mit Acrylsäureester zu den ungewöhnlichen Anthron-Derivaten 12b und 12c.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198419840213
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    Paper (German National Licenses)
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