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  • 1
    Electronic Resource
    Electronic Resource
    Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic a cells in ducks (1981)
    Springer
    Diabetologia 20 (1981), S. 72-77 
    Details
    ISSN: 1432-0428
    Keywords: Glucose ; insulin ; glucagon ; glucose metabolism ; A cell ; 2-deoxyglucose ; subtotal pancreatectomy ; ducks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A possible action of insulin via glucose metabolism on the pancreatic A cell response to glucose, was studied in ducks. 2-Deoxyglucose, a non metabolizable analogue of glucose was used. In normal ducks, the hyperglycaemia induced by 2-deoxyglucose (IV: 0.5g/kg) resulted in hyper glucagonaemia, while the same degree of hyper glycaemia, induced by glucose infusion (IV injection 25 mg/kg, and infusion 5 mg/kg/min) immediately suppressed glucagon secretion. In diabetic ducks, two days after subtotal pancreatectomy, glucose responsiveness of the A cell was abolished, but could be restored by insulin treatment before (IM 0.2 U/kg insulin + 8 μg/kg glucagon every 6 h) and during (IV 3.6 mU/kg + infusion 0.9 mU/kg/min) the glucose test (IV: 0.5 g /kg). The normal response of the A cell to glucose was not observed in diabetic insulintreated ducks after the administration of 2-deoxyglucose (IV: 0.5 g/kg). These data suggest an inhibitory effect of the metabolism of glucose on the release of glucagon. In addition, the action of insulin on the A cell may be mediated by its effect on glucose metabolism within the A cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253821
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Roles of insulin and glucose in the regulation of plasma FFA in the duck (1978)
    Springer
    Diabetologia 14 (1978), S. 185-190 
    Details
    ISSN: 1432-0428
    Keywords: Duck ; adipose tissue ; FFA release ; glucagon ; insulin ; glucose uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was undertaken to determine how free fatty acid (FFA) release by adipose tissue can occur in the absence of pancreatic glucagon, the most potent lipolytic hormone in the duck. Two possible explanations have successively been investigated. Replacement therapy experiments showed that glucose uptake was implicated in the phenomenon; indeed, when pre-operative insulin and glucose levels were restored after total pancreatectomy, plasma FFA progressively fell to a level significantly lower than the pre-operative value. The same effect was observed when the ducks were kept in a continuous state of hyperglycaemia, whereas “normal” levels of insulin or glucose alone were shown to be ineffective. On the other hand a compensatory mechanism for the lack of glucagon, by other lipolytic agents [with the intestine or the anterior pituitary as possible sources] has been excluded by associating the removal of these two organs with pancreatectomy. These experiments suggest that the lack of pancreatic glucagon induced by total pancreatectomy is essentially masked by a failure in glucose uptake due to the operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429779
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of insulin on glucagon secretion mediated via glucose metabolism of pancreatic A cells in ducks (1981)
    Springer
    Diabetologia 21 (1981), S. 72-77 
    Details
    ISSN: 1432-0428
    Keywords: Glucose ; insulin ; glucagon ; glucose metabolism ; A cell ; 2-deoxyglucose ; subtotal pancreatectomy ; ducks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A possible action of insulin via glucose metabolism on the pancreatic A cell response to glucose, was studied in ducks. 2-Deoxyglucose, a non-metabolizable analogue of glucose was used. In normal ducks, the hyperglycaemia induced by 2-deoxyglucose (IV: 0.5 g/kg) resulted in hyperglucagonaemia, while the same degree of hyperglycaemia, induced by glucose infusion (IV injection 25 mg/kg, and infusion 5 mg/kg/min) immediately suppressed glucagon secretion. In diabetic ducks, two days after subtotal pancreatectomy, glucose responsiveness of the A cell was abolished, but could be restored by insulin treatment before (IM 0.2 U/kg insulin+8 μg/kg glucagon every 6 h) and during (IV 3.6 mU/kg+infusion 0.9 mU/kg/min) the glucose test (IV: 0.5 g /kg). The normal response of the A cell to glucose was not observed in diabetic insulin-treated ducks after the administration of 2-deoxyglucose (IV: 0.5 g/kg). These data suggest an inhibitory effect of the metabolism of glucose on the release of glucagon. In addition, the action of insulin on the A cell may be mediated by its effect on glucose metabolism within the A cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01789118
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Reduced phagocytosis of monocytes from patients with tuberculosis under treatment (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 544-548 
    Details
    ISSN: 1432-1440
    Keywords: Monocytes ; phagocytosis ; tuberculosis ; antituberculous therapy ; Monocyten ; Phagocytose ; Tuberkulose ; Tuberkulostatika
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird von vergleichenden Monocyten-Funktionstest bei 15 Tuberkulosekranken und 15 gesunden Normalpersonen berichtet. Die Ausbreitungs- und Haftfähigkeit der Tbc-Monocyten ist gegenüber der Norm significant gesteigert, die Phagocytose von IgG-beladenen Erythrocyten signifikant vermindert. Diese Funktionseinschränkung beruht mit Wahrscheinlichkeit auf einer Blockade des IgG-Rezeptors oder einer Verminderung seiner Dichte auf der Zellmembran. 14 der untersuchten Fälle erhielten im Rahmen einer kombinierten tuberkulostatischen Therapie Rifampicin. Eine immunsuppressive Wirkung von Rifampicin ist auch in therapeutisch üblichen Dosen belegt. Es wird diskutiert, ob die verminderte Phagocytose-Aktivität durch Rifampicin bedingt ist. Die Beeinflussung des IgG-Rezeptors des Makrophagen bietet gleichzeitig eine Erklärungsmöglichkeit für die Unterdrückung der Delayed-Hypersensitivity-Reaktionen durch Rifampicin.
    Notes: Summary Tests of several monocyte functions were performed in fifteen patients with tuberculosis under treatment and fifteen healthy normal persons in parallel. The spreading activity and the attachment rate of the tbc-monocytes on the bottom of a plastic petri dish was significantly enhanced, the phagocytosis of IgG-coated red cells significantly impaired. The reduction of this monocyte function probably depends upon a blockade or modification of the monocyte IgG-receptor. Fourteen patients received antituberculous therapy including rifampicin. The immunosuppressive effect of rifampicin is well established; thus the impairment of phagocytosis could be induced by rifampicin. The modification of the IgG-receptor in addition could be an explanation for the suppression of delayed hypersensitivity reactions by rifampicin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468726
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Reduced monocyte phagocytosis in patients with advanced Hodgkin's disease and lymphosarcoma (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 437-440 
    Details
    ISSN: 1432-1440
    Keywords: Monocyten ; Phagocytose ; NBT-Test ; M. Hodgkin ; Lymphorsarkom ; Monocytes ; phagocytosis ; NBT test ; M. Hodgkin ; lymphosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The monocytes of 7 patients with advanced Hodgkin disease (stages III and IV) and of two patients with generalized lymphosarcoma exhibited a highly significant impairment of the phagocytosis of IgG-coated red cells, regardless of receiving therapy or not. In contrast three patients with M. Hodgkin, stage II B, and one with lymphorsarcoma in complete remission showed a rather elevated monocyte phagocytic activity. The nitroblue tetrazolium reduction by monocytes in the mean was significantly enhanced in all patients investigated, compared with normal persons, although only in one patient a bacterial infection was apparent at the time of the test. The possible implication of the findings in the well known immunodeficiency present in M. Hodgkin and lymphosarcoma is discussed.
    Notes: Zusammenfassung Die Monocyten von 7 Patienten mit fortgeschrittenem M. Hodgkin (Stadium III und IV) und von 2 Patienten mit generalisiertem Lymphosarcom zeigten eine hoch signifikant verminderte Phagocytose von IgG-beladenen Erythrocyten, unabhängig davon, ob eine Therapie bereits durchgeführt war oder nicht. Demgegenüber war die Phagocytose-Aktivität bei 3 Patienten mit M. Hodgkin, Stadium II und einem mit Lymphosarkom in Vollremission eher gegenüber der Norm gesteigert. Die Reduktion von Nitroblau-Tetrazolium durch Monocyten war bei allen untersuchten Patienten im Vergleich zu Normalpersonen im Mittel signifikant gesteigert, obwohl nur ein Patient zum Zeitpunkt der Untersuchung einen gesicherten bakteriellen Infekt aufwies. Die mögliche Bedeutung dieser Befunde für die bei diesen Erkrankungen bestehenden Immundefekte wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01493369
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    Paper (German National Licenses)
    Fulltext
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