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  • Computed tomography, liver  (1)
  • JEL classification: J51, L22, L40  (1)
  • Prostaglandin synthase  (1)
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  • 1
    ISSN: 1432-0509
    Keywords: Computed tomography, liver ; Echinococcus ; Liver, cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An unusual case of hepatic hydatidosis complicated by transphrenic migration of the hydatid cyst passing through the right hemidiaphragm, and penetrating the inferior pulmonary lobe causing a bronchial fistula, is presented. The computed tomographic (CT) study permitted the correct preoperative diagnosis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Spanish economic review 2 (2000), S. 129-144 
    ISSN: 1435-5477
    Keywords: JEL classification: J51, L22, L40 ; Key words: Mergers, multiproduct firms, wage bargaining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract. This paper shows that, when two firms merge, the increase in the bargaining strength of the multiproduct firm arising from the merger when negotiating uniform wages with the workers is one of the reasons that account for corporate mergers. Moreover, there is a strategic variable that can be used to decrease union rents in the case of merging, namely, the organization of production decisions.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-4951
    Keywords: QSAR ; Conformational analysis ; Prostaglandin synthase ; Antiinflammatory ; Amfenac
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The new nonsteroidal antiinflammatory drug (NSAID) arylacetic amfenac (2-amino-3-benzoylphenylacetic acid) and 19 substituted derivatives were studied in order to correlate the biological activities with the structure-related parameters. The geometry of amfenac in neutral and anionic form was totally optimized, starting from standard geometries and crystallographic data, using semiempirical AM1 and MNDO quantum-mechanical methods. Conformational analysis shows the existence of a rigid structure for rotations of the acetic acid chain (α°) and the central carbonyl group (γ°) around the bonds with the phenylamine ring, whereas the carboxyl group (β°) and the phenyl ring of the benzoyl group (δ°) can rotate almost freely. Electrostatic potential maps were analyzed and showed that the electrostatic orientation effect seems to make an important contribution to the binding of the active compounds to prostaglandin synthase. An electrostatic orientation model of the binding site is proposed. The frontier orbital charge distribution was also described for each compound. On the other hand, steric, electronic and hydrophobic (log P) parameters were calculated and QSAR analysis showed that the most significant parameter for the antiinflammatory activity was the π-electron density of the HOMO orbital in the second aromatic ring. These results suggest a possible electronic charge transfer between the aromatic fragments and the receptor.
    Type of Medium: Electronic Resource
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