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  • Anti-YopB antiserum  (1)
  • Purine metabolism  (1)
  • translation  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Transcriptional and translational regulation of IL-1α and IL-1β account for the control of IL-1 in experimental yersiniosis
    Amsterdam : Elsevier
    Cytokine 6 (1994), S. 504-511 
    Details
    ISSN: 1043-4666
    Schlagwort(e): IL-1α and IL-1β ; transcription ; translation ; yersinia-infection
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/1043-4666(94)90078-7
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Eubacterium angustum sp. nov., a Gram-positive anaerobic, non-sporeforming, obligate purine fermenting organism (1984)
    Springer
    Archives of microbiology 140 (1984), S. 2-8 
    Details
    ISSN: 1432-072X
    Schlagwort(e): Eubacterium angustum ; Purine metabolism ; Xanthine dehydrogenase ; Selenium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A strictly anaerobic, uric acid, xanthine, and guanine fermenting bacterium was isolated from sewage sludge requiring thiamine as a vitamin. Acetate, formate, ammonia and CO2 were products. Cells were Gram-positive, straight rods, 3 to 6.5 μm long and 1.1 to 1.5 μm wide. They were non-motile, however, possessed flagella. Spore formation could not be obtained. The guanine-plus-cytosine content (G+C) of its deoxyribonucleic acid was 40.3 mol%. Based on these features, the organism belongs to the genus Eubacterium. Due to its restricted substrate spectrum and its inability to utilize arginine or to form cytochromes like E. lentum, this organism did not resemble any of the previously described species of Eubacterium. Therefore, it is proposed to form a new species Eubacterium angustum sp. nov.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00409763
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  • 3
    Digitale Medien
    Digitale Medien
    Tumor necrosis factor-α expression induced by anti-YopB antibodies coincides with protection against Yersinia enterocolitica infection in mice (1997)
    Springer
    Medical microbiology and immunology 185 (1997), S. 223-229 
    Details
    ISSN: 1432-1831
    Schlagwort(e): Key wordsYersinia enterocolitica ; YopB ; Tumor necrosis factor-α ; Anti-YopB antiserum ; Infection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Previous studies have suggested that virulence of pathogenic Yersiniae is associated with a suppression of the local cytokine response. In this context, the plasmid-encoded 41-kDa Yersinia outer protein B (YopB) has been implicated with the lack of tumor necrosis factor-α (TNF-α) expression in Peyer's patches (PP), following oral infection of mice with the enteropathogenic Yersinia enterocolitica. The present study was performed to further evaluate the relationships between YopB-induced suppression of TNF-α and bacterial survival in host tissue. Results are presented to show the ability of purified YopB to suppress the release of TNF-α by macrophages, the effect of which was neutralized by monospecific anti-YopB antiserum. In mice orally infected with Y. enterocolitica, anti-YopB treatment on days 3 and 5 postinfection, significantly decreased the recovery of live bacteria from PP. This observation correlated with a strong increase in TNF-α expression, as determined by reverse transcription-polymerase chain reaction and measuring the levels of TNF activity in homogenates of PP. Moreover, treatment of mice with a combination of anti-YopB and anti-TNF-α antiserum, completely abrogated the beneficial effect of the anti-YopB antiserum. In controls, expression of other proinflammatory cytokines such as interleukin-1 remained unaffected by either treatment. Therefore, the results indicate that endogenous TNF-α is required for eradication of Y. enterocolitica from host tissue, and further imply that YopB significantly contributes to suppression of the local TNF-α response in PP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004300050034
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