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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of sleep EEG microstructure in subchronic paroxetine treatment of healthy subjects (1997)
    Springer
    Psychopharmacology 132 (1997), S. 44-49 
    Details
    ISSN: 1432-2072
    Keywords: Key words Microstructure ; Sleep EEG ; Spectral power analysis ; Paroxetine ; Healthy subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paroxetine is a selective and potent serotonin reuptake inhibitor and its efficacy for the treatment of depression has been proven. Under acute and subchronical treatment regimens, disturbances of the regular sleep pattern are a reported side effect of the drug. The present study was therefore performed to investigate the impact of subchronic treatment with the selective serotonin reuptake inhibitor paroxetine on the microstructure of the sleep EEG. The study especially addressed the question of subchronic effects of paroxetine medication (30 mg/day) in eight healthy male volunteers in a double blind, placebo-controlled crossover design. Conventional sleep EEG parameters and a spectral power analysis for different sleep stages after 4 weeks of treatment were computed. Additionally, the correlation of certain EEG rhythms across the night was calculated in order to detect subtle dynamical EEG alterations, not necessarily obvious when regarding conventional EEG analysis. Although we could not detect any alterations of the spectral power values in certain frequency bands either during NREM nor during REM sleep following subchronic paroxetine medication, the dynamical EEG attributes across the night revealed a significant enhancement of the correlation between certain EEG rhythms mainly during NREM sleep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050318
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Human sleep under the influence of pulsed radiofrequency electromagnetic fields: A polysomnographic study using standardized conditions (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 19 (1998), S. 199-202 
    Details
    ISSN: 0197-8462
    Keywords: cellular phone ; sleep EEG ; REM sleep ; spectral power density ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: To investigate the influence of radiofrequency electromagnetic fields (EMFs) of cellular phone GSM signals on human sleep electroencephalographic (EEG) pattern, all-night polysomnographies of 24 healthy male subjects were recorded, both with and without exposure to a circular polarized EMF (900 MHz, pulsed with a frequency of 217 Hz, pulse width 577 μs, power flux density 0.2 W/m2. Suppression of rapid eye movement (REM) sleep as well as a sleep-inducing effect under field exposure did not reach statistical significance, so that previous results indicating alterations of these sleep parameters could not be replicated. Spectral power analysis also did not reveal any alterations of the EEG rhythms during EMF exposure. The failure to confirm our previous results might be due to dose-dependent effects of the EMF on the human sleep profile. Bioelectromagnetics 19:199-202, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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