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  • 1
    Electronic Resource
    Electronic Resource
    Effect of interferon-α on DOI-induced wet-dog shakes in rats (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 947-955 
    Details
    ISSN: 1435-1463
    Keywords: Serotonin ; interferon ; wet-dog shake ; opioid receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute (1h) intraperitoneal (ip) treatment with interferon (IFN)-α-2a (300IU/g) significantly inhibited wet-dog shakes (WDS) induced by (±)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. IFN-α did not affect spontaneous locomotion. The inhibition of DOI (0.5mg/kg)-induced WDS by IFN-α was dose (90–300 IU/g)- and time (1–6 h)-dependent, and was prevented by 30 min pretreatment with naltrexone (NLTX; 1.0mg/kg, ip), an opioid receptor antagonist. Acute (1h) intracerebroventricular (icv) treatment with IFN-α (1,500IU/rat) also inhibited DOI (0.5mg/kg)-induced WDS, and the effect was blocked by NLTX (50μg/rat, icv). These results suggest that IFN-α may modulate 5-HT2 receptor-mediated behavior through opioid receptors in the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01291785
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Predictive factors for psychological distress in ambulatory lung cancer patients (1998)
    Springer
    Supportive care in cancer 6 (1998), S. 281-286 
    Details
    ISSN: 1433-7339
    Keywords: Key words Lung cancer ; Psychological distress ; Coping ; Social support
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although there is a need for systematic research on the psychosocial issues faced by lung cancer patients, there have been few studies in this area. The objective of the present study was to investigate potential predictors of psychological distress among ambulatory lung cancer patients. The variables examined included the patients' characteristics, coping responses, and social support factors. Lung cancer patients completed the Profile of Mood States (POMS) and the Mental Adjustment to Cancer scale (MAC scale), and information pertaining to demographic variables and social support factors was obtained from them at a structured interview. Evaluable data were obtained from 87 patients. The results of multiple regression analysis indicated that female gender, living alone, no children in the role of confidant, nurses as confidants, and helplessness/hopelessness as a coping style were predictive for psychological distress. Information on patients' demographic variables and psychosocial correlates of psychological distress may later be useful in developing interventions to facilitate their adjustment to lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005200050167
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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