ISSN:
1435-1463
Keywords:
Kampo
;
hypothermia
;
flat body posture
;
5-HT-1A receptors
;
anxiety
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (±)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by O.1mg/kg 8-OH-DPAT was enhanced by 500 and 750mg/kg of TJS-010. At the concentration of O.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750mg/ kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01292617
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