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  • 1
    Electronic Resource
    Electronic Resource
    Regulatory properties of neuronal cdc2-like kinase (1995)
    Springer
    Molecular and cellular biochemistry 149-150 (1995), S. 35-39 
    Details
    ISSN: 1573-4919
    Keywords: neuronal cdc2-like kinase ; cdk5 ; regulatory subunit ; neurofilament proteins ; tau ; Alzheimer disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Neuronal cdc2-like kinase, nclk, is a heterodimer of cyclin dependent protein kinase 5, cdk5, and a 25 kDa subunit derived from a novel, neuron-specific, 35 kDa protein: p35. The characterization and regulation of nclk will be summarized in this minireview. The activity of nclk appears to be governed by highly complex regulatory mechanisms including protein-protien interaction, protein phosphorylation and isoforms. The histone H1 kinase activity of nclk is absolutely dependent of the interaction between the 25 kDa subunit and the catalytic subunit, cdk5. In addition, nclk interacts with other cellular proteins to form macromolecular complexes. The kinase activity of nclk is inhibitedin vitro by the phosphorylation reactions of a weel-like protein tyrosine kinase and a protein serine/threonine kinase from bovine thymus. Northern blot analysis has revealed the existence of two populations of p35 mRNA of 2 and 4 kb. A novel cDNA encoding a p35 homologous protein has been obtained from a human hippocampus library.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01076561
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Emulsification using environmental compatible emulsifiers and de-emulsification using D.C. field and immobilized Nocardia amarae (2000)
    Springer
    Biotechnology letters 22 (2000), S. 1157-1163 
    Details
    ISSN: 1573-6776
    Keywords: de-emulsification ; emulsification ; immobilization ; Nocardia amarae ; polysaccharides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract As environmental compatible emulsifiers, various polysaccharides were investigated and de-emulsification methods were studied using filtration, direct current (D.C.) field, and also Nocardia amarae. 0.01% (v/v) of alginic acid, arabic gum, chitosan, and curdlan showed more than about 2 h of emulsion stability in the half-life of emulsion layer by a homogenizer and showed about twice synergic effects with other polysaccharides in emulsification activity at the ratio of 9:1 (v/v). De-emulsification by 110V D.C. field took about 1 h for the separation of oils from 1 l of oil-in-water emulsion in case of 0.01% arabic gum. Oil-water separator was designed using non-woven fabrics in filtration system and Nocardia amarae grown in n-hexadecane or kerosene was immobilized in the non-woven fabrics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005601525934
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    Paper (German National Licenses)
    Fulltext
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