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  • haloperidol  (3)
  • Apomorphine  (2)
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  • 1
    Digitale Medien
    Digitale Medien
    Involvement of dopaminergic neurotransmission in the control of goal-directed movements (1983)
    Springer
    Psychopharmacology 80 (1983), S. 360-364 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Predatory behavior ; Neuroleptics ; Apomorphine ; Bromocriptine ; Dopamine receptors ; Ferret
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Changes produced in dopamine (DA) activity, by administration of the DA-antagonists metoclopramide (10 mg/kg IM) and tiapride (16 mg/kg IM) and of the DA agonists apomorphine (0.5 and 1 mg/kg IM) and bromocriptine (8 mg/kg orally), specifically modified predatory behavior in the ferret. Sulpiride (40 mg/kg IP and 90 mg/kg IM) did not change the behavior. The number of bites necessary to kill the prey was reduced by metoclopramide and tiapride. The number of bites after the death of the prey was not changed. The latency from the first bite to the death of the prey was shortened. Apomorphine and bromocriptine increased the number of bites. The DA receptor blockers haloperidol, chlorpromazine, and clozapine had similar effects to metoclopramide and tiapride, and the DA agonist l-dopa had similar effects to apomorphine and bromocriptine. The pattern of results indicated that, considering the two major DA receptor types, D-2 receptors or D-2 in combination with D-1 but not D-1 receptors alone were involved in the control of goal-directed movements. The results also provided some evidence that blockade of these DA receptors caused a narrowing of the range of exhibited behavioral responses. Stimulation of these DA receptors had opposite effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00432121
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  • 2
    Digitale Medien
    Digitale Medien
    Haloperidol- and apomorphine-induced changes in pup searching behaviour of house mice (1988)
    Springer
    Psychopharmacology 95 (1988), S. 271-275 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Dopamine ; Maternal behaviour ; Response-switching ; Apomorphine ; Haloperidol ; House mouse
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which is adequate to activate species specific pup searching behaviour or towards a 20 kHz tone (neutral stimulus), thus showing her preference for one of these stimuli. Under apomorphine (0.00625; 0.0125; 0.025 mg/kg) the females preferred the key stimulus. Nevertheless apomorphine (0.00625–0.025 mg/kg) prolonged response latencies and shortened the duration of pup searching. At the highest dose (0.05 mg/kg), apomorphine induced stereotyped sniffing. Haloperidol (0.025; 0.05; 0.1 mg/kg) had opposite effects to apomorphine: it lowered the threshold for elicitation, shortened response latencies and prolonged the duration of pup searching. Females treated with haloperidol (0.025–0.1 mg/kg) did not prefer the key stimulus. Changes in response elicitation and in the performance of pup searching induced by apomorphine and haloperidol, respectively, were assumed to be due to i) a reduced and an increased responsiveness to external stimuli respectively, ii) an enhanced and a reduced tendency for response switching respectively, and iii) a preference for spontaneous behaviour in apomorphine-treated females, with an increased dependence on exteroceptive stimuli following haloperidol.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00174523
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  • 3
    Digitale Medien
    Digitale Medien
    MK-801-induced stereotypy and its antagonism by neuroleptic drugs (1990)
    Springer
    Journal of neural transmission 81 (1990), S. 173-182 
    Details
    ISSN: 1435-1463
    Schlagwort(e): NMDA-receptor ; MK-801 ; haloperidol ; clozapine ; stereotypy ; sniffing ; locomotion ; rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo-(a,d)cyclo-hepten-5, 10-imine hydrogen maleate], which blocks glutamatergic transmission at the NMDA-receptor-gated ion chanel, induced stereotypies which are similar to those found after intrastriatal injections of AP-5, e.g. sniffing and locomotion. Tests in familiar or unfamiliar environment (non-stressful or stressful situation) did not qualitatively change MK-801-induced effects. Haloperidol (0.1mg/kg, IP) delayed the onset and shortened the duration of MK-801 (0.16; 0.33mg/ kg, IP)-induced stereotypy whereas clozapine (5 mg/kg, SC) potently antagonized it. However, exact quantification of sniffing, measured in an experimental chamber designed for this purpose, revealed an antagonism by both drugs, haloperidol as well as clozapine. Stereotypy is considered to represent an animal model of schizophrenia, and the antagonism of stereotypy with classical (haloperidol) as well as with atypical (clozapine) antipsychotic drugs is in accordance with the glutamate hypothesis of schizophrenia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01245040
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  • 4
    Digitale Medien
    Digitale Medien
    Discrete quinolinic acid lesions of the lateral but not of the medial caudate-putamen reversed haloperidol-induced catalepsy in rats (1993)
    Springer
    Journal of neural transmission 94 (1993), S. 103-114 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Catalepsy ; spontaneous locomotor activity ; quinolinic acid ; haloperidol ; lateral caudate-putamen ; medial caudate-putamen ; rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Discrete lesions in the medial or lateral subregion of the rostral caudate-putamen (CP) were induced by bilateral intracerebral injections of a low dose of quinolinic acid (30 nmol in 1 μl/per side) in rats. Quinolinic acid lesions in the lateral CP potently reversed haloperidol-induced catalepsy (0.5 mg/ kg,i.p.), while lesions in the medial CP were not effective. Spontaneous locomotor activity was not altered significantly after quinolinic acid lesions of either the medial or lateral CP. These results show that the lateral CP seems to be important for the expression of neuroleptic-induced catalepsy and thus further corroborate the concept of a functional heterogenity of the striatum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01245004
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  • 5
    Digitale Medien
    Digitale Medien
    Glycine site antagonists abolish dopamine D 2 but not D 1 receptor mediated catalepsy in rats (1994)
    Springer
    Journal of neural transmission 95 (1994), S. 123-136 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Glycine ; NMDA ; 7-chlorokynurenate ; (R)-HA-966 ; haloperidol ; SCH 23390 ; dopamine ; D 1, D 2, catalepsy ; Parkinson's disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Catalepsy—a state of postural immobility (akinesia) with muscular rigidity (rigor)—and reduced locomotion in animals are behavioral deficits showing similarities with symptoms of Parkinson's disease (PD). The effects of the glycine site antagonists 7-chlorokynurenate and (R)-HA-966 on haloperidol-(D2 antagonist) and SCH 23390-(D 1 antagonist) induced catalepsy and reduced locomotion are investigated in rats. Both antagonists dose-dependently counteract dopamine D 2 receptor mediated catalepsy but they have no influence on locomotion. Neither 7-chlorokynurenate nor (R)-HA-966 has any effect on dopamine D 1 receptor mediated catalepsy. This finding is surprising, since NMDA receptor antagonists counteract both, dopamine D 1 and D 2 receptor mediated catalepsy. D 1 and D 2 receptors are located on different populations of neurons. Thus, the present findings suggest that these different neuronal populations have different sensitivity for ligands binding at the glycine binding site of the NMDA receptor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01276431
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