ISSN:
1432-1041
Keywords:
nitroglycerin
;
aspirin
;
pharmacological interaction
;
pharmacokinetic interaction
;
healthy subjects
;
physiological effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The interaction between nitroglycerin (NTG) and aspirin was investigated in 7 healthy subjects in order to test whether aspirin could block the haemodynamic response to NTG; the doses used were NTG 0.8 mg, and aspirin 0.5 g for chronic and 1 g for acute treatment. The plasma levels of NTG and various physiological parameters (heart rate, diastolic arterial pressure, end diastolic diameter, and end systolic diameter) were measured during the 30 minutes after the administration of NTG. An increase in NTG Cmax and AUC was observed after both aspirin treatment. The changes in physiological parameters produced by NTG were enhanced by the two treatments, although the differences were not statistically significant. The results indicate complex pharmacokinetic and pharmacodynamic interactions between NTG and aspirin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542519
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