ISSN:
0942-0940
Keywords:
Argyrophilic nucleolar organizer regions (AgNORs)
;
invasiveness
;
meningioma
;
proliferating cell nuclear antigen (PCNA)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A study was undertaken to investigate the correlation between histological invasiveness and proliferating potential and clinical recurrence in meningioma. In 39 meningiomas, the histological findings at the tumour-brain interface zone were classified into 3 types, consisting of 29 cases of non-invasion (NON), 7 cases of nodular invasion (NOD), and 3 cases of intermingled invasion (INT). Proliferating cell nuclear antigen (PCNA) and argyrophilic nucleolar organizer region (AgNOR) indices were studied. PCNA indices (mean±standard error) of NON, NOD, and INT were 1.7±0.1%, 5.2±0.5%, and 7.5±0.7%, respectively, and the AgNOR indices (dot number/nucleus) were 1.50±0.03, 2.00±0.04, and 2.22±0.07, respectively. Significant differences were found among the three types in both parameters. Clinically, tumour recurrence was observed in 1/29 NON, 4/7 NOD, and 2/2 INT cases, indicating a higher incidence of recurrence in invasive meningiomas (NOD plus INT). Four of 32 patients who underwent gross total removal of the tumours showed recurrence, and all of these four tumours were invasive meningiomas. The results of the present study showed that tumour invasiveness as measured by PCNA + AgNOR indices correlated well with high proliferative potential and clinical recurrence.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01410613
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