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  • 1
    Electronic Resource
    Electronic Resource
    Histopathological predictive factors in Ewing's sarcoma of bone and clinicopathological correlations (1986)
    Springer
    Virchows Archiv 409 (1986), S. 627-640 
    Details
    ISSN: 1432-2307
    Keywords: Ewing's sarcoma ; Bone ; Histology ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A retrospective multifactorial analysis on 261 previously untreated patients with Ewing's sarcoma (Es) of bone has been carried out in order to ascertain the prognostic value of several histological variables on survival. Among those cases accepted as Es, 208 (80% of the patients) were considered to be “typical Es”, while 40 (15%) displayed a large cell predominance, being subclassified as “atypical large cell Es”. Furthermore, 13 patients (5%) possessed tumours of endothelial-like appearance. Eleven cases which displayed a mixed histological configuration were finally included within one of the three previous groups according to their predominant histological pattern. After adjustment for therapeutic regimens and initial location of the tumour, only two histological characteristics remain significant; i.e. the presence of necrosis (p=0.002) and, to a lesser degree, the presence of filagree “en damier” pattern (p=0.08), both of which are of poor prognostic value. From this study, it can be assumed that the morphological (and possibly histogenetical) heterogeneity of Es of bone has no prognostic influence on survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713429
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Primary breast sarcoma: A review of 33 cases with immunohistochemistry and prognostic factors (1989)
    Springer
    Breast cancer research and treatment 13 (1989), S. 39-48 
    Details
    ISSN: 1573-7217
    Keywords: primary sarcomas ; breast sarcoma ; cystosarcoma phyllodes ; immunohistochemistry ; histograde ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and pathological features of 33 previously untreated patients with primary breast sarcoma were retrospectively analysed to evaluate the prognostic significance of histologic variables on survival. The series comprised 17 cystosarcomas phyllodes and 16 stromal sarcomas (excluding angiosarcomas). All tumors were reviewed and classified in similar fashion to extramammary soft tissue sarcomas. In addition, immunohistochemical studies were performed on paraffin sections with a panel of several antibodies directed against cytoskeletal filaments and cellular enzymes; five cases were also examined by electron microscopy. Most tumors were malignant fibrous histiocytoma (21 cases) and fibrosarcoma (6 cases) types. Surgery was the main therapy. Metastasis-free survival rate was significantly correlated only with histological grade, consisting of tumor differentiation, tumor necrosis, and mitotic activity. Courses and survivals of the cystosarcoma and stromal groups were identical, questioning the clinical value of this pathologic distinction. All local recurrence, metastasis, or death occurred within 30 months, though follow-up was much longer. Immunohistochemistry was disappointing for identification of specific histologic sub-types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01806549
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Invasive apocrine carcinoma of the breast: A long term follow-up study of 34 cases (1988)
    Springer
    Breast cancer research and treatment 12 (1988), S. 37-44 
    Details
    ISSN: 1573-7217
    Keywords: apocrine carcinomas ; infiltrating breast cancer ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have reviewed the morpho-functional criteria for infiltrating apocrine carcinomas of the breast and analysed long term follow-up of this entity. Thirty-four cases of pure apocrine carcinomas were retrieved from the files of the Dept. of Pathology, IGR, France, for the years 1955–1982. Each case was matched with two controls of other infiltrating ductal carcinomas according to the most important prognostic parameters: nodal status, histograde, anatomic tumor size, and patient age. No significant difference between the survival curves of the two groups was seen. Apocrine carcinoma, although possessing peculiar morphological, ultrastructural, biochemical, and immunohistochemical features to merit recognition as a separate histologic variant of breast cancer, by itself has no apparent clinical significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805738
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    Paper (German National Licenses)
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