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  • serum concentration  (2)
  • (Thylakoid membrane)  (1)
  • Carcinoma colorectal  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Studies on the nature of the water-oxidizing enzyme. I. The effect of trypsin on the system-II reaction pattern in inside-out thylakoids
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Bioenergetics 766 (1984), S. 582-591 
    Details
    ISSN: 0005-2728
    Schlagwort(e): (Thylakoid membrane) ; Oxygen evolution ; Photosystem II ; Trypsin ; Water splitting
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Medizin , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2728(84)90118-X
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  • 2
    Digitale Medien
    Digitale Medien
    Absorption of β-methyl-digoxin determined after a single dose and under steady state conditions (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 307-314 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Absorption ; man ; β-methyl-digoxin ; serum concentration ; urinary excretion ; radio-immunoassay
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Single doses of β-methyl-digoxin 0.4 mg were given to groups of 17 – 18 healthy volunteers as an intravenous infusion lasting 2 hours, or orally as Lanitop Liquidum® or Lanitop® tablets. The serum glycoside concentration and urinary glycoside excretion were measured over 8 and 32 h. The absolute bioavailability from the oral preparations in comparison with the infusion was lower for the first 8 h than for the entire 32 h of the investigation; the relative bioavailability from tablets was the same as from the solution for both periods. For both periods the area under the serum concentration/time curve and the urinary glycoside excretion were significantly lower after administration of the tablets than after intravenous infusion. Taking the average of both parameters, the absolute bioavailability of β-methyl-digoxin was about 80% from the solution and about 70% from the tablets. In 18 patients undergoing intravenous or oral therapy with β-methyl-digoxin steady state glycoside concentrations were compared in a cross-over study of intravenous maintenance therapy with Lanitop® ampoules or oral treatment with Lanitop® tablets. For a standard daily dose of 0.2 mg β-methyl-digoxin the serum concentrations were 1.35±0.10 ng/ml during both intravenous and oral administration. The intra-individual variation in glycoside concentration after changing from intravenous to oral maintenance therapy, or vice versa, was about the same as during continued intravenous or oral administration. It is concluded that the rate of rise of serum concentration after a single dose may be a useful indicator of the rate of absorption, but that the area under the serum concentration/time curve and the urinary glycoside excretion up to 32 h are unsuitable for determining equivalent doses of different formulations or routes of administration of digitalis glycosides.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561665
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  • 3
    Digitale Medien
    Digitale Medien
    Serum glycoside concentrations after single or repeated intravenous doses ofβ-methyl-digoxin and digoxin (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 213-218 
    Details
    ISSN: 1432-1041
    Schlagwort(e): β-Methyl-digoxin ; digoxin ; intravenous administration ; man ; serum concentration ; renal clearance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The aim of the present investigation was to estimate the ratio of the intravenous doses ofβ-methyl-digoxin and digoxin required to produce identical serum glycoside concentrations in man. 20 patients on intravenous maintenance therapy were changed fromβ-methyl-digoxin to the identical dose of digoxin or vice versa. Each drug was given for 7 days. Serum concentrations 13% higher were found during administration ofβ-methyl-digoxin. Assuming a half life of 60 h after with drawal, the dose of digoxin producing the same minimum serum concentration was estimated to be 1.16 times higher than that ofβ-methyl-digoxin. 18 healthy volunteers received 0.4 mg β-methyldigoxin, and 23 the same dose of digoxin, as an intravenous infusion over 2 h. The serum concentrations and urinary glycoside excretion were measured over a period of 32 hrs. During the first hour after the infusion the serum concentration of digoxin declined more rapidly than that ofβ-methyl-digoxin. Thereafter, the ratio of the serum concentrations did not change appreciably up to the end of the investigation. The area under the serum concentration/time curve was about 13% greater forβ-methyl-digoxin than for digoxin; this difference was not significant. The average renal clearance was 96±9 ml forβ-methyl-digoxin, 151±13 ml for digoxin. Since the total body clearance of digoxin is only about 1.16 times higher than that ofβ-methyl-digoxin, the lower renal clearance ofβ-methyl-digoxin must partly be compensated by higher extrarenal clearance. From the ratios of the areas under the serum concentration/time curves after single doses of β-methyldigoxin and digoxin, and the minimum serum concentrations during maintenance therapy, it was concluded that the dose of digoxin to produce the same average serum concentrations would be about 1.15 times higher than that ofβ-methyl-digoxin. In comparison with the large variations in individual dosage of digoxin andβ-methyl-digoxin, this difference is too small to be of practical importance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00606413
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  • 4
    Digitale Medien
    Digitale Medien
    173. Diagnostische Effizienz der rectal-digitalen Untersuchung : Ergebnis einer prospektiven Studie bei 2000 Patienten (1978)
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 662-663 
    Details
    ISSN: 1435-2451
    Schlagwort(e): Carcinoma colorectal ; Polyps colorectal ; Rectal digital examination, diagnostic efficacy of ; Dickdarmcarcinom ; Dickdarmpolyp ; Vergleich: rectal digitale-endoskopische Untersuchung
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In einer prospektiven Studie wurden 2000 Patienten von zwei Ärzten rectal-digital untersucht, und anschließend rektoskopiert. Es fanden sich 312 Tumore (127 Carcinome), 463 sonstige pathologische Befunde, 1225 Untersuchungen waren o.B. 75 von 312 Tumoren (24,0%) wurden von mindestens einem, 44 (14,1%) von beiden richtig getastet. Von den Tumoren, die auf den ersten 10 cm ab ano lagen, wurden nur 44% getastet, 56% der in dieser Region gelegenen und in zahlreichen Retrospektivstudien als palpabel bezeichnete Tumore konnten nicht getastet werden.
    Notizen: Summary Of utmost importance is the fact that, of the tumors located in the first 10 cm ab ano, only 44% were palpable and 56% were not palpable. In a prospective study 2000 patients were examined by two medical doctors rectal-digitally and by rectoscopy. The findings included 312 tumors (127 carcinomas) and 463 other pathologic conditions. 1225 examinations were without pathologic findings. Seventy-five of 312 tumors (24.0%) were palpable for one of the examiners; 44 (14,1%) were palpated by both examiners. Therefore rectal digital examination is not apt to uncover midrectal tumors; rectoscopy should be performed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01579466
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