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  • 1
    Electronic Resource
    Electronic Resource
    Atrial natriuretic polypeptide in patients with subarachnoid haemorrhage due to aneurysmal rupture (1989)
    Springer
    Acta neurochirurgica 97 (1989), S. 53-61 
    Details
    ISSN: 0942-0940
    Keywords: Atrial natriuretic polypeptide (ANP) ; hyponatremia ; subarachnoid haemorrhage ; cerebral salt wasting syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Measurement of plasma alpha-humanANP (ANP) and antidiuretic hormone (ADH) in 28 cases with aneurysmal subarachnoid haemorrhage (SAH) was carried out, and then compared with control subjects who were infused with hypertonic saline. In cases with hyponatremia (HN), statistical correlation between control subjects and cases without HN was not evident with regards to ANP and plasma osmolality (Posm), excreted fraction of filtrated sodium (FENa) and urinary Na/K. Furthermore, they secreted supernumerarilly in spite of HN. Cases with HN were further subdivided into two groups, they were those cases with negative total sodium balance at the time of appearance of HN, and those cases without total negative sodium balance. In the former, central venous pressure had a tendency to decrease, however, secretion of ANP and ADH was statistically not different in either groups. It appears that ANP regulated urinary sodium excretion against an osmotic or sodium load acts as a maintenance of homeostasis as an osmotic regulator. Cases with HN in which secretion of ADH was physiological, ANP secreted supernumerarilly in spite of hypoosmonaemia and hypovolaemia. Our findings may contribute to a better understanding of the pathophysiological processes leading to hyponatremia in cases with cerebral disorders, and may help to improve the treatment possibilities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01577740
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  • 2
    Electronic Resource
    Electronic Resource
    Time course of csf lactate level in subarachnoid haemorrhage correlation with clinical grading and prognosis (1989)
    Springer
    Acta neurochirurgica 99 (1989), S. 127-134 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial aneurysm ; subarachnoid haemorrhage ; cerebrospinal fluid ; lactic acidosis ; cisternal drainage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cisternal and/or ventricular cerebrospinal fluid (CSF) and arterial blood lactate and acid-base balance were measured serially in 38 patients with aneurysmal subarachnoid haemorrhage (SAH). Based on daily clinical assessment, the patients and accordingly the samples were divided into two groups according to the grading of the World Federation of Neurosurgical Societies (W.F.N.S.). In cisternal CSF, samples of Grade III–V showed significantly higher lactic acidosis than those of Grade I–II. The time course of lactate and pH in poor prognosis groups had a significant tendency of lactic acidosis, especially on the 5th, 6th, 7th day after SAH. Ventricular CSF lactate increased even without CSF acidosis in Groups III–V. Measurement of CSF lactate, especially from the cisterna magna is useful as an indicator of prognosis and changes of intracranial environment following SAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402321
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Alterations of monoamine metabolites and of tryptophan in the basal cisternal CSF of patients after subarachnoid haemorrhage (1987)
    Springer
    Acta neurochirurgica 87 (1987), S. 58-62 
    Details
    ISSN: 0942-0940
    Keywords: Homovanillic acid (HVA ; 5-hydroxyindoleacetic acid (5-HIAA) ; Tryptophan (TRP) ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and tryptophan (TRP) were measured in the CSF obtained from the basal cistern of 20 patients, who had undergone surgical obliteration of bleeding aneurysms within 3 days after subarachnoid haemorrhage (SAH). The concentrations of these substances, which were assayed by high performance liquid chromatography (HPLC), were the highest on days 3 or 4, and thereafter showed a gradual decrease with an increase in time. The cisternal CSF in patients who had severe pre-operative clinical grades of SAH or vasospasm contained relatively higher concentrations of HVA, 5-HIAA and TRP than those contained in patients who did not. It is proposed that SAH stimulates the release of monoamines from the brain with the resultant extracellular accumulation of their metabolites and their diffusion into CSF during the acute stage. This stimulatory effect of SAH on the brain monoamine system may be consistent with those previously reported in cases of cerebral haemorrhage or infarction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02076018
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of 1,2-diacylglycerol and cholesterol on the hydrolysis activity of phospholipase D in egg-yolk phosphatidylcholine bilayers
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 1145 (1993), S. 293-297 
    Details
    ISSN: 0005-2736
    Keywords: 1,2-Diacylglycerol ; Cholesterol ; Phosphatidylcholine ; Phospholipase D
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(93)90302-G
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of α-tocopherol and its acetate on the hydrolytic activity of phospholipase D in egg yolk phosphatidylcholine bilayers (1994)
    Springer
    Colloid & polymer science 272 (1994), S. 598-603 
    Details
    ISSN: 1435-1536
    Keywords: Phospholipase D ; α-tocopherol ; α-tocopherol acetate ; egg yolk phosphatidylcholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Effects of α-tocopherol (Toc) and α-tocopherol acetate (TocA) on the hydrolysis activity of phospholipase D (fromStreptomyces chromofuscus) were studied in small unilamellar vesicles (SUV) of egg yolk phosphatidylcholine (PC). Choline produced in the reaction was monitored by use of a choline oxidase — oxygen electrode. Addition of 18 mol% Toc into SUV (2 mM PC) brought about a twofold rate of choline production. On the other hand, the effect of 18 mol% TocA in SUV was very small. The apparent maximum velocity,V max(app), increased by addition of Toc in SUV. The apparent Michaelis constant,K m(app), was unchanged by addition of Toc and TocA in SUV. The Toc and TocA molecules did not have significant effects when PC was solubilized in the micelles of heptaethylene glycol dodecyl ether. The effects of Toc and TocA are, therefore, not due to specific ones on the enzyme itself, but rather upon the bilayer-organization of the substrate. Measurements of spreading pressure showed complete miscibility of PC and Toc, and limited mutual solubility of PC and TocA, suggesting stronger attractive interactions between Toc and PC than those between TocA and PC in the bilayers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00653227
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    Paper (German National Licenses)
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