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Digitale Medien

Dose dependent pharmacokinetics of prednisolone (1977)

Pickup, M. E. ; Lowe, J. R. ; Leatham, Patricia A. ; [weitere]

Springer

European journal of clinical pharmacology 12 (1977), S. 213-219

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Details

ISSN: 1432-1041

Schlagwort(e): Prednisolone pharmacokinetics ; intravenous dosing ; plasma clearance ; half-life ; volume of distribution ; plasma protein

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The pharmacokinetics of prednisolone elimination have been studied in both arthritic patients and normal volunteers using tritiated prednisolone alone, and in conjunction with unlabelled prednisolone in doses of 0.15 mg·kg−1 and 0.3 mg·kg−1 body weight. With increasing dose there is prolongation of the plasma half-life and increase in the volume of distribution and plasma clearance of prednisolone. It is proposed that these changes in pharmacokinetic parameters may be associated with non-linear binding of the steroid to plasma proteins.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00609864

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