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  • 1
    Electronic Resource
    Electronic Resource
    Referate (1968)
    Springer
    Annals of hematology 17 (1968), S. 245-251 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01631601
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  • 2
    Electronic Resource
    Electronic Resource
    Nanosecond and femtosecond probing of the dynamics of the UV-photodissociation of perfluoroethyliodide C2F5I (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 11157-11165 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The ns photodissociation of perfluoroethyliodide C2F5I at 266 nm has been studied by using the resonant two-photon ionization (R2PI) technique. Recoil anisotropy parameters as well as average translational energy of the I atoms in the fine structure states 2P1/2 and 2P3/2 have been determined. The main contribution (99%) to the absorption at 266 nm was found to be caused by a parallel transition to the 3Q0 state which gives mainly excited-state atoms I(2P1/2). The ground-state atoms I(2P3/2) were found to appear mainly (88%) from the primarily excited 3Q0 state via curve-crossing 3Q0–1Q1 and to a lesser extent (12%) from direct absorption by a perpendicular transition to the 1Q1 and 3Q1 states. The fs pump–dump technique in combination with ns R2PI probing of the fragments I(2P1/2) and I(2P3/2) and time-of-flight mass spectrometry have been applied to probe the early stage dynamics of the C2F5I molecule on the excited state 3Q0 potential energy surface (PES). The evolution time of the excited molecule to the point where the energy gap between the excited state 3Q0 and the ground-state potential energy surfaces drops to a value of about 12 440 cm−1 was found to be 52±13 fs. This time corresponds to about 0.8 Å extension of the C–I bond distance. The molecular dynamics simulation with DFT calculated ground-state PES and 3Q0 PES with the shape calculated for methyl iodide found in the literature gives reasonable agreement with the experimental result for the evolution time. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1418743
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  • 3
    Electronic Resource
    Electronic Resource
    Immunophenotype of hairy-cell leukaemia after cold polymerization of methyl-methacrylate embeddings from 50 diagnostic bone marrow biopsies (1997)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 30 (1997), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hairy-cell leukaemia may be difficult to diagnose in bone marrow biopsies, especially in the early stages or in its residum after complete clinical remission. To consider the impact of published data on immunophenotyping hairy-cell leukaemias, a total of 50 diagnostic biopsies were systematically analysed with a panel of eight antibodies and compared with cases of chronic lymphatic leukaemia (CLL), 20 follicular centre lymphomas, 20 lympho-plasmacytoid immunocytomas, 10 small-cell T-cell non-Hodgkin lymphomas and 20 cases of benign nodular lymphatic hyperplasia. The panel of eight antibodies comprised DBA44, CD45, CD20, CD45R, CD45R0, CD43 and the CD68 antibodies KP1 and Ki-M1P. The hairy-cell leukaemias were staged histologically into four categories of bone marrow infiltration. DBA44 reacted positively in 47/50 cases. CD45 and the B-cell markers CD20 and CD45R reacted in 49/50 and 43/50 cases, respectively. One CD68 marker, KP1, was positive in 38/50 cases but the other — Ki-M1P — only in 1/50 cases. Chronic lymphatic leukaemia cases, the other B-cell NHLs and lymphatic hyperplasias showed strong positivity for CD20 and CD45R, but only the immunocytomas reacted with DBA44 in 7/20 cases. The T-cell NHLs and hyperplasias showed a strong positivity for the T-cell markers CD45R0 and CD43. The CD68-marker Ki-M1P revealed a high specificity, since it was negative in all NHLs and positive only in one hairy-cell leukaemia. Methyl-methacrylate embedding of bone marrow biopsies under cold polymerization produces a high quality of histo- and cytomorphology, resulting in greater diagnostic reliability and the detection of low-stage infiltration of hairy-cell leukaemia. DBA44 appears as a highly specific antibody to mark hairy-cells since only immunocytomas reacted positively in a few cases. A small panel of antibodies including DBA44, CD20, CD45R and Ki-M1P may serve to distinguish small-cell NHL from hairy-cell leukaemia even at an early stage or when there are minimal residual tumour cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1997.d01-581.x
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  • 4
    Electronic Resource
    Electronic Resource
    Demonstration of the Philadelphia translocation by fluorescence in situ hybridization (FISH) in paraffin sections and identification of aberrant cells by a combined FISH/immunophenotyping approach (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 26 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Philadelphia translocation was demonstrated by two-colour fluorescence in situ hybridization (FISH) in decalcified paraffin sections of bone marrow from patients with chronic myelogenous leukaemia. FISH was combined with immunocytochemical detection of different membrane-bound or cytoplasmic antigens. With this new technique, the cells bearing the 9;22 translocation can be identified morphologically, as well as immunocyto-chemically, in tissue sections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00250.x
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  • 5
    Electronic Resource
    Electronic Resource
    The site of inhibin production in ovarian neoplasms (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 29 (1996), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Inhibin, a physiological product of ovarian follicle cells, normally absent in serum of postmenopausal women, is elevated in adult granulosa cell tumours of the ovary. Recently, high serum levels of inhibin were reported in carcinomas and, surprisingly, also in Krukenberg tumours of the ovary. This study attempted to determine the site of inhibin production in primary (111 cases), metastatic (13) and secondary (10) ovarian tumours by using immunohistochemistry. Positive staining in tumour cells was encountered in all cases of sex-cord- stromal cell tumours, adult (13) and juvenile (3) granulosa cell tumours, thecofibromas (10), in a lipid cell tumour (1) and a Sertoli-Leydig cell tumour (1). Primary and secondary tumours not derived from sex-cord stroma revealed no positivity in tumour cells, but in theca-like cells in the surrounding non-neoplastic ovarian stroma. A positive reaction was not observed in non-tumour-bearing ovaries of a control group. The ovarian inhibin of postmenopausal women is derived from activated sex-cord stroma or sex-cord-stromal neoplasms. Therefore, elevated serum inhibin concentrations in women with primary or secondary ovarian neoplasms with other histogenesis seem to be due to an activation of the non-neoplastic ovarian stroma. Inhibin will fail to be a tumour marker in these cases. By contrast, it will be useful in proving sex-cord differentiation by immunohistochemistry and might be used in surveillance of malignant sex-cord derived neoplasms by serum assays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1996.d01-511.x
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  • 6
    Electronic Resource
    Electronic Resource
    Three isodicentric Philadelphia chromosomes in acute phase of chronic myeloid leukemia: A case report
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 20 (1986), S. 29-33 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(86)90104-4
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  • 7
    Electronic Resource
    Electronic Resource
    Chromosome 1 abnormalities in hepatocellular carcinoma
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 66 (1993), S. 130 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(93)90243-F
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  • 8
    Electronic Resource
    Electronic Resource
    Hairy cell leukemia (1976)
    Springer
    Virchows Archiv 370 (1976), S. 273-289 
    Details
    ISSN: 1432-2307
    Keywords: Bone marrow biopsy ; Hairy cell leukemia ; Differential diagnosis ; Myelofibrosis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 24 patients with hairy cell leukemia, histological and fine structural findings from biopsies of the bone marrow are reported and their validity is compared with other diagnostic procedures available. Diagnosis by light microscopy of anterior iliac crest biopsies obtained by the method of myelotomy is possible with a high degree of accuracy. The differentiation of hairy cell leukemia from other myelo- or lymphoproliferative disorders based on cytomorphology as well as patterns of growth is emphasized. Morphological differences between fibrosis in this entity and other lesions such as malignant lymphomas, Hodgkin's disease, osteomyelofibrosis and -sclerosis are emphasized. Electron microscopy of the bone marrow shows single fibroblastic cells with numerous slender cytoplasmic processes randomly dispersed among the hairy cells. These fibroblasts are probably responsible for the synthesis of the reticulin and collagen fibres in their surroundings. Moreover fine structure of the hairy cells demonstrates pinocytic activity but no apparent phagocytosis in contrast to the phagocytic reticulum cells (histiocytes, macrophages). In the bone marrow the precursor cells and the many immature forms of hairy cells exhibit an overall lymphocytoid appearance during their maturation, suggesting a lymphocytic origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445773
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  • 9
    Electronic Resource
    Electronic Resource
    The differentiation of atypical adenomas and encapsulated follicular carcinomas in the thyroid gland (1980)
    Springer
    Virchows Archiv 385 (1980), S. 125-141 
    Details
    ISSN: 1432-2307
    Keywords: Follicular carcinoma of thyroid ; Atypical adenoma ; Encapsulated follicular carcinoma ; Vascular invasion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den Jahren 1968–1977 wurden insgesamt 1394 follikuläre Tumoren der Schilddrüse in einem Operationsgut von 4612 Strumen diagnostiziert. 1159 follikuläre Tumoren waren zweifelsfrei als Adenome einzuordnen. Alle übrigen follikulären Tumoren mit zunächst unklarer Dignität aber auch solche mit eindeutig invasivem Wachstum wurden histologisch eingehend nachuntersucht. Daraus resultierten 125 atypische Adenome, 55 weitgehend abgekapselte follikuläre Carcinome und 55 ausgedehnt invasive Carcinome. Bei 102 Tumoren stützte sich die endgültige Diagnose auf die histologische Nachuntersuchung von 10 Gewebsentnahmen aus dem kapselnahen Bereich. Dabei wurde die Zahl der Tumoreinbrüche in prae- oder postcapilläre Blutgefäße und die Zahl der kompletten Kapseldurchbrüche registriert. Bei 17/36 (47%) abgekapselten Carcinomen waren jeweils nur ein oder zwei Gefäßeinbrüche festzustellen. In diesen Fällen wurden die vorhandenen 10 Gewebsblöcke pro Tumor in 20 weiteren Schnittstufen aufgearbeitet und bei 6/17 zusätzliche Gefäßeinbrüche gefunden. Die quantitative Auswertung hat ergeben, daß der Nachweis von Gefäßeinbrüchen häufiger gelingt als der von Kapseldurchbrüchen und damit ein besserer Hinweis für die Malignität eines abgekapselten follikulären Tumors ist. Allerdings ist die Untersuchung von 10 Entnahmestellen das Minimum für eine zuverlässige Diagnose und mit Sicherheit nicht durch Schnittstufen mit weniger Gewebsblöcken zu erreichen. Der bisherige postoperative Verlauf aller in dieser Studie erfaßten Patienten rechtfertigt die nach den angegebenen Kriterien vorgenommene Unterscheidung zwischen atypischen Adenomen und abgekapselten follikulären Carcinomen.
    Notes: Summary From 1968 to 1977 a total of 1,394 follicular neoplasms were seen in surgical material containing 4,612 thyroid glands. 1,159 tumors were obviously benign adenomas. All remaining follicular tumors with equivocal histological appearances were extensively re-examined, together with all apparently invasive follicular carcinomas. Thereby, 125 atypical adenomas, 55 encapsulated and 55 widely invasive follicular carcinomas were diagnosed. In 102 tumors a definite diagnosis was reached after excision and histological examination of ten tissue blocks from preserved wet material. In each case the number of blood vessel invasions and penetrations of tumor capsule was recorded. Among these tumors, 17/36 (47%) encapsulated carcinomas proved to be only slightly invasive. All their tissue blocks were cut into sequential sections and in 6/17 cases additional vascular invasions found. It was shown by this study that the proof of vascular invasion is more often successful than the proof of capsular penetration and therefore a better indication of malignancy in encapsulated follicular tumors. Examination of 10 tissue blocks represents the minimum effort to estimate the invasive capability of a follicular tumor, whereas sequential sections through less than 10 blocks are of little help in most cases. A follow-up study of all patients included here seems to justify the distinction we have made between atypical adenomas and encapsulated follicular carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427399
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  • 10
    Electronic Resource
    Electronic Resource
    Chronic megakaryocytic granulocytic myelosis — CMGM (1980)
    Springer
    Virchows Archiv 389 (1980), S. 253-268 
    Details
    ISSN: 1432-2307
    Keywords: Chronic myeloid leukemia ; Chronic megakaryocytic granulocytic myelosis ; Myelofibrosis, beginning ; Histopathology ; Philadelphia chromosome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 1,083 core biopsies of the bone marrow with myeloproliferative diseases 454 cases or 42% were found to have neoplastic megakaryopoiesis. Neoplasia of megakaryocytes was assumed from the conspicuous cytological atypicality revealed by light microscopy, extending and confirming earlier ultrastructural findings. Histopathology of the bone marrow in these patients was described as chronic megakaryocytic-granulocytic myelosis — CMGM — since neutrophilic granulopoiesis is also apparently neoplastic and both cell lineages showed a complete differentiation to mature forms. CMGM should be separated from the chronic granulocytic leukemia — CGL — which consists of only a single line proliferation. The incidence of CGL in our total of 1,083 patients was 25%. Both entities are included in chronic myeloid leukemia — CML — because of the demonstration of the Philadelphia chromosome in the hematopoietic cells of these two groups of patients. Primary or idiopathic thrombocythemia has to be differentiated from CMGM since there is no evidence for malignancy of the granulocytic series.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430654
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