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  • 1
    Digitale Medien
    Digitale Medien
    Isradipine improves platelet function in hypertensives (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 43-46 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Isradipine ; hypertension ; platelet function ; prostaglandin system ; adverse effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect of treatment for eight weeks with isradipine 1.25 mg twice daily for 4 weeks and thereafter 2.5 mg twice daily for 4 weeks on ex vivo platelet function was investigated in 10 male hypertensive patients, aged 51 (6.1) y. Systolic and diastolic blood pressure, platelet aggregation in response to ADP, serum thromboxane B2 and β-thromboglobulin levels were significantly decreased at rest before exercise ergometry, during exercise and at rest after exercise. The platelet count, platelet sensitivity and the plasma levels of 6-oxo-prostaglandin F1α were not affected by isradipine. It is concluded that a compound that lowers blood pressure and inhibits platelet activation may be of clinical benefit in the routine treatment of hypertension.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00314918
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of low-dose prednisolone on cyclosporine pharmacokinetics in liver transplant recipients: radioimmunoassay with specific and non-specific monoclonal antibodies (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 257-260 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Cyclosporine pharmacokinetics ; Prednisolone ; Liver transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The following study of cyclosporine pharmacokinetics was performed to investigate the effects of withdrawal of low-dose maintenance prednisolone (0.3–0.6 mg/kg body weight) from the routine immunosuppressive regimen given to 10 liver transplant recipients with stable liver function tests. After oral administration of cyclosporine (6.4–10.3 mg/kg) whole blood concentrations were measured by radioimmunoassay (RIA) with both a specific monoclonal antibody detecting parent drug and a non-specific antibody additionally detecting a cross-section of metabolites. Withdrawal of prednisolone produced no significant change in the mean time and concentration of maximum blood cyclosporine (3.3 h and 1160 μg/l, respectively), the initial and terminal elimination half-life (3.5 h and 18.4 h, respectively) and the area under the blood concentration versus time curve (AUC) measured with either the specific or non-specific monoclonal antibody. Measurements with these two antibodies indicated that the terminal elimination of cyclosporine metabolites was more rapid than for the parent drug (half-life: 14.5 vs 18.4, respectively).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00315106
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  • 3
    Digitale Medien
    Digitale Medien
    Hepatic α-interferon expression in cytomegalovirus-infected liver allograft recipients with and without vanishing bile duct syndrome (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 191-196 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Liver transplantation ; α-Interferon ; Cytomegalovirus ; Vanishing bile duct syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In previous studies cytomegalovirus (CMV) infection was identified as one risk factor in the development of vanishing bile duct syndrome (VBDS) after orthotopic liver transplantation (OLT), but its precise role in relation to the pathogenesis of tissue damage is uncertain. In the present study a-interferon (α-IFN) expression in the liver was studied as an indirect marker of viral infection in serial liver biopsies from 42 patients following OLT. α-IFN was identified more frequently in the bile duct cytoplasm of patients developing VBDS, with or without evidence of preceding CMV infection (7/8 and 4/5 cases, respectively), when compared with patients with acute CMV but without evidence of VBDS (6/19 cases; P〈0.05) or those with neither complication (2/10 cases; P〈0.01). α-IFN was detectable in bile duct cytoplasm for a longer period in patients developing VBDS than in those with acute CMV infection alone (median 14 weeks and range 9–19, median 6 weeks and range 1–11 weeks, respectively; P〈 0.025). These data indicate that persistent CMV infection of bile duct cells is a likely co-factor linked to progression to VBDS, but the processes that allow persistent viral infection and bile duct destruction remain to be determined.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00180101
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