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  • 1980-1984  (7)
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  • 1
    Digitale Medien
    Digitale Medien
    Lysophosphatidylserine as histamine releaser in mice and rats (1984)
    Springer
    Inflammation research 14 (1984), S. 619-625 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Lysophosphatidylserine is a specific inducer of histamine release in isolated mast cells. To determine whether a similar effect is manifestin vivo, the phospholipid was injected (1–5 mg/kg i.v.) into mice and rats. A dosedependent rise in blood histamine was observed in both animals. The several-fold increase in blood histamine occurred in the first minutes and was followed by a slower decline toward normal values. A second dose of lysophosphatidylserine was without effect. Systemic manifestations (depression, hypothermia, hypotension) were associated with the increased blood histamine level. When the tissue histamine stores accessible to lysophosphatidylserine were previously decreased by repeated phospholipid injections, no systemic symptoms occurred. Mobilization of carbohydrate reserves was also manifest during the action of lysophosphatidylserine. Prior treatment with compound 48/80 induced sustained refractoriness to lysophosphatidylserine. Structure-activity relationship demonstrated that the property to induce histamine release was linked to the structure of serine head group. Thus, other natural phospholipids or lysophospholipids were inactive. It is concluded that in analogy with the effect seenin vitro lysophosphatidylserine producesin vivo release of mast cell histamine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01978896
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  • 2
    Digitale Medien
    Digitale Medien
    Modulation of lysophosphatidylserine-dependent histamine release (1984)
    Springer
    Inflammation research 14 (1984), S. 376-378 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Apomorphine (2–30 μM) inhibits lysophosphatidyl-serine-dependent histamine release in rat and mouse peritoneal mast cells. The drug-induced inhibition is influenced by the concentration of lysophosphatidylserine. Log concentration-response curves show a surmountable type of antagonism between the two compounds.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01973832
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  • 3
    Digitale Medien
    Digitale Medien
    Local effects of lysophosphatidylserine in rats (1984)
    Springer
    Inflammation research 14 (1984), S. 606-612 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To study the inflammatory properties of lysophosphatidylserine (a phospholipid acting as a histamine releaser), rats were subjected to local treatment with this compound. In the paw a rapid and dose-dependent edematous reaction occurred within 30–60 min (ED50 2.5 μg/rat). The effect was dependent on the intact configuration of serine head group since lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidic acid andN-acetimidyl-lysophosphatidylserine were uneffective. Indomethacin produced a weak inhibition but chlorpheniramine and cyproheptadine inhibited 50 and 70%, respectively. Consistently, the histamine stores of the paw were found to be decreased at the end of the lysophosphatidylserine effect. Increase in vascular permeability was observed also after the injection of lysophosphatidylserine into the dorsal skin and pleural cavity although the phospholipid was less effective in these regions. The fluid extravasation in the pleural cavity was 75% prevented by cyproheptadine. Parallelin vitro experiments showed that the effect of lysophosphatidylserine on isolated pleural and peritoneal mast cells is increased when a leukocyte lysate was also added. After centrifugation the activity was retained in the insoluble fraction. It is concluded that lysophosphatidylserine, injected locally, elicits an inflammatory reaction mediated by the components of mast cell granulus. The response may be amplified by the migration of other inflammatory cells into the exudate.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01978894
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  • 4
    Digitale Medien
    Digitale Medien
    A histofluorescent procedure for identifying marijuana cannabinoids (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 886-888 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary A rapid and reliable fluorescence procedure is described as a test for the microscopical identification of the glandular hairs ofCannabis sativa. The proposed method, designated as the IFIM test (induced fluorescence identification for marijuana test), is based on the induction of a red fluorescence in cannabinoids by a hot clearing solution. The results, compared to those obtained by the classical RIM test, offer the possibility of more satisfactory identification of cannabis, hashish or marijuana in suspected samples.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01990420
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  • 5
    Digitale Medien
    Digitale Medien
    Different responses of rodent mast cells to lysophosphatidylserine (1984)
    Springer
    Inflammation research 14 (1984), S. 613-618 
    Details
    ISSN: 1420-908X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The lysophosphatidylserine-induced activation of mast cells has been studied in preparations obtained from different rodents. In mouse and gerbil peritoneal mast cells lysophosphatidylserine behaves as an agonist, inducing noncytotoxic histamine release at 0.2–8 μM. In rat peritoneal and pleural mast cells lysophosphatidylserine is ineffective, but the histamine-releasing activity becomes manifest upon the addition of suboptimal concentrations of other mast cell activators. The common structure-activity relationship shows the link between these effects of lysophosphatidylserine but the calcium requirement indicates differences in the mechanism of action. Histamine release in mouse mast cells is independent of external calcium. Thus, lysophosphatidylserine induces mobilization of endogenous calcium stores in these cells. By contrast, histamine release in gerbil and rat mast cells is dependent on the addition of external calcium indicating that the phospholipid promotes calcium influx. While in gerbil mast cells calcium influx is promoted by lysophosphatidylserine alone, in rat it requires the combined action of the phospholipid and other mast cell agonists. Differently from lysophosphatidylserine, compound 48/80 elicits histamine release in rat and gerbil mast cells. Mouse mast cells are unaffected. Thus, gerbil mast cells are the only preparation in which the action of these two agonists can be observed simultaneously.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01978895
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  • 6
    Digitale Medien
    Digitale Medien
    A method for localizing embryonal laticifers by combined conventional and fluorescence microscopy (1980)
    Springer
    Protoplasma 102 (1980), S. 343-347 
    Details
    ISSN: 1615-6102
    Schlagwort(e): Double staining ; Euphorbiaceae ; Fluorescent staining ; Laticifers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary The authors describe a simple method based on malachite green and acid fuchsin for the detection of laticifers during the embryogenesis of someEuphorbiaceae plants by conventional and fluorescence microscopy. The strong sensitivity and specificity of the method make it suitable for the ontogenetic studies of laticifers. The results obtained are discussed in the context of the reactive mechanism of the staining and of the chemical composition of the embryonal laticifers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01279597
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  • 7
    Digitale Medien
    Digitale Medien
    Two rapid fluorescence procedures for the detection of some thio pungent compounds in plant tissues (1980)
    Springer
    Journal of molecular histology 12 (1980), S. 1-7 
    Details
    ISSN: 1573-6865
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Two rapid flourescence procedures are described for detecting sulphydryl, disulphide and isothiocyanate groups of scented and pungent principles present in the vacuolar sap of onion, garlic and cabbage. To localize compounds containing sulphydryl groups, fresh or fixed frozen sections of the plants were treated with mercurochrome. After the fluorochromization, strongly-positive sulphydryl sites emitted an intense orange-red fluorescence, while weakly-positive sites emitted a distinctive red-brown fluorescence. Disulphide groups were detected by first reducing with thioglycolic acid to thiol groups before treating with mercurochrome. To effect isothiocyanate localization, frozen sections were exposed to ammonia: isothiocyanates were converted to thioureas and the engendered amino groups were revealed with fluorescamine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01066532
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