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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 86 (1993), S. 36-41 
    ISSN: 1432-0533
    Schlagwort(e): Alzheimer's disease ; β/A4 deposits ; Morphological types ; Spatial pattern ; Clustering
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The spatial patterns of diffuse, primitive, classic (cored) and compact (burnt-out) subtypes of β/A4 deposits were studied in coronal sections of the frontal lobe and hippocampus, including the adjacent gyri, in nine cases of Alzheimer's disease (AD). If the more mature deposits were derived from the diffuse deposits then there should be a close association between their spatial patterns in a brain region. In the majority of tissues examined, all deposit subtypes occurred in clusters which varied in dimension from 200 to 6400 μm. In many tissues, the clusters appeared to be regularly spaced parallel to the pia or alveus. The mean dimension of the primitive deposit clusters was greater than those of the diffuse, classic and compact types. In about 60% of cortical tissues examined, the clusters of primitive and diffuse deposits were not in phase, i.e. they alternated along the cortical strip. Clusters of classic deposits appeared to be distributed independently of the diffuse deposit clusters. Cluster size of the primitive deposits was positively correlated with the density of the primitive deposits in a tissue but no such relationship could be detected for the diffuse deposits. This study suggested that there was a complex relationship between the clusters of the different subtypes of β/A4 deposits. If the diffuse deposits do give rise to the primitive and classic varieties then factors unrelated to the initial deposition of β/A4 in the form of diffuse plaques were important in the formation of the mature deposits.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Mathematical geology 31 (1999), S. 85-103 
    ISSN: 1573-8868
    Schlagwort(e): dispersion covariances ; Pearson correlation ; multivariate geostatistics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Mathematik
    Notizen: Abstract This paper extends the concept of dispersion variance to the multivariate case where the change of support affects dispersion covariances and the matrix of correlation between attributes. This leads to a concept of correlation between attributes as a function of sample supports and size of the physical domain. Decomposition of dispersion covariances into the spatial scales of variability provides a tool for computing the contribution to variability from different spatial components. Coregionalized dispersion covariances and elementary dispersion variances are defined for each multivariate spatial scale of variability. This allows the computation of dispersion covariances and correlation between attributes without integrating the cross-variograms. A correlation matrix, for a second-order stationary field with point support and infinite domain, converges toward constant correlation coefficients. The regionalized correlation coefficients for each spatial scale of variability, and the cases where the intrinsic correlation hypothesis holds are found independent of support and size of domain. This approach opens possibilities for multivariate geostatistics with data taken at different support. Two numerical examples from soil textural data demonstrate the change of correlation matrix with the size of the domain. In general, correlation between attributes is extended from the classic Pearson correlation coefficient based on independent samples to a most general approach for dependent samples taken with different support in a limited domain.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Mathematical geology 31 (1999), S. 701-722 
    ISSN: 1573-8868
    Schlagwort(e): dispersion covariances ; spatial support ; Pearson correlation ; spatial scales of variability ; PCA ; matrix variogram
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Mathematik
    Notizen: Abstract Principal component analysis (PCA) is commonly applied without looking at the “spatial support” (size and shape, of the samples and the field), and the cross-covariance structure of the explored attributes. This paper shows that PCA can depend on such spatial features. If the spatial random functions for attributes correspond to largely dissimilar variograms and cross-variograms, the scale effect will increase as well. On the other hand, under conditions of proportional shape of the variograms and cross-variograms (i.e., intrinsic coregionalization), no scale effect may occur. The theoretical analysis leads to eigenvalue and eigenvector functions of the size of the domain and sample supports. We termed this analysis “growing scale PCA,” where spatial (or time) scale refers to the size and shape of the domain and samples. An example of silt, sand, and clay attributes for a second-order stationary vector random function shows the correlation matrix asymptotically approaches constants at two or three times the largest range of the spherical variogram used in the nested model. This is contrary to the common belief that the correlation structure between attributes become constant at the range value. Results of growing scale PCA illustrate the rotation of the orthogonal space of the eigenvectors as the size of the domain grows. PCA results are strongly controlled by the multivariate matrix variogram model. This approach is useful for exploratory data analysis of spatially autocorrelated vector random functions.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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