ISSN:
1420-9071
Schlagwort(e):
D-Cysteinolic acid
;
platelet aggregation
;
inhibitor
;
marine product
;
2-aminoethyl disulfide
;
sardine
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Summary D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01950172
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