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Digitale Medien

Effect of hydrogen peroxide on the metabolism of articular chondrocytes (1999)

Asada, S. ; Fukuda, K. ; Oh, M. ; [weitere]

Springer

Inflammation research 48 (1999), S. 399-403

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ISSN: 1420-908X

Schlagwort(e): Key words: Annexin V — Chondrocytes — Nitric oxide — Apoptosis — MAP kinase

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract. Objective: To examine the effect of hydrogen peroxide on chondrocyte metabolism.¶Materials and Methods: Bovine articular chondrocytes were used. Proteoglycan (PG) synthesis was measured with [35S] sulfate incorporation. For detection of apoptosis, the TdT-mediated dUTP-biotin nick end labeling (TUNEL) and annexin V assay were used. Extracellular-regulated protein kinase (ERK) activity was measured using a mitogen-activated protein kinase assay system.¶Results: Addition of hydrogen peroxide resulted in the inhibition of PG synthesis, apoptosis, and enhanced ERK activity.¶Conclusion: Hydrogen peroxide plays an important role in regulating the metabolism of chondrocytes.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s000110050478

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