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Digitale Medien

Mathematische Modelle in der Hämatologie (1983)

Wichmann, H. E. ; Loeffler, M. ; Herkenrath, P. ; [weitere]

Springer

Journal of molecular medicine 61 (1983), S. 935-940

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ISSN: 1432-1440

Schlagwort(e): Mathematical models ; Blood formation ; Stem cells ; Erythropoiesis ; Thrombopoiesis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The use of mathematical models in haematology is shown by some examples concerning stem cell kinetics, erythropoiesis and thrombopoiesis. At first, model assumptions are formulated which include the biological knowledge and some regulatory hypotheses. Then, the reaction of the model on stimulation and suppression is calculated. Finally, by comparison with experimental or clincal data one can evaluate how far the model assumptions are sufficient to understand the measurements. Thus one can exclude wrong hypotheses and identify the important regulatory influences.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01550265

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Digitale Medien

Growth dependent cell proliferation kinetics of a human malignant melanoma grown in nude mice (1985)

Wickramanayake, P. Dias ; Loeffler, M. ; Klein, H. O. ; [weitere]

Springer

Journal of cancer research and clinical oncology 110 (1985), S. 11-16

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ISSN: 1432-1335

Schlagwort(e): Tumour growth ; Cell kinetics ; Melanoma ; Nude mice

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary A human malignant melanoma was grown in nude mice. The tumour showed an exponential growth for several weeks which gradually slowed down, until following week 8 the tumour growth ceased. The reasons for this growth pattern were examined by labelling techniques (PLM, LI). The tumour cell production as quantified by the growth fraction, showed only a moderate reduction which, taken alone, could not explain the growth cessation. The important mechanism seems to be an increased loss of tumour cells during the intermitotic interval. While the loss of cells/h remains constant the total intermitotic cell loss is increased because the cell cycle times are prolonged by 50% from the exponential phase (45 h in week 3) to the plateau phase (66 h in week 8).

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00402496

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