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  • 1
    Digitale Medien
    Digitale Medien
    Disposition kinetics, urinary excretion and dosage regimen of kanamycin in buffalo calves following single intravenous administration (1993)
    Springer
    Veterinary research communications 17 (1993), S. 219-225 
    Details
    ISSN: 1573-7446
    Schlagwort(e): buffalo ; disposition ; dose ; kanamycin ; pharmacokinetics ; serum ; urine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The distribution and elimination half-lives were 0.12±0.01 h and 1.94±0.11 h, respectively. The apparent volume of distribution and total body clearance were 0.2±0.01 L/kg and 92.9±3.69 ml/kg/h, respectively. About 74% of the administered dose was excreted in urine in 24 h. A suitable dosage regimen for the intravenous administration of kanamycin was also calculated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01839170
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and dosage regimen of cefotaxime in cross-bred calves following single intramuscular administration (1994)
    Springer
    Veterinary research communications 18 (1994), S. 313-318 
    Details
    ISSN: 1573-7446
    Schlagwort(e): calves ; cefotaxime ; cephalosporin ; dose ; intramuscular ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The pharmacokinetics, penetration into erythrocytes and plasma protein binding of cefotaxime were investigated in cross-bred calves. Following a single intramuscular dose of cefotaxime (10 mg/kg), the absorption half-life and elimination half-life were 0.13±0.03 h and 2.97±0.72 h, respectively. The apparent volume of distribution and total body clearance were 3.28±0.72 L/kg and 0.78±0.08 L/kg per h, respectively. The extent of penetration into erythrocytes was 24–40% of the total blood concentration. Cefotaxime was bound to plasma proteins of calves to the extent of 25.5–33.6%. A satisfactory intramuscular dosage regimen for cefotaxime in calves would be 11 mg/kg followed by 10 mg/kg at 7 h intervals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01839199
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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