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  • 11
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 67 (1995), S. 854-856 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We fabricated screen-printed Ag-(Bi,Pb)2Sr2Ca2Cu3Ox monofilament and multifilament tapes with filament number 1≤N≤5. As N increases, the critical current Ic increases monotonically until it reaches 54 A (77 K, 0 T) for N=5, while the critical current density Jc is around 1.6×104 A/cm2 (77 K, 0 T) nearly independent of N. The bend strain tolerance is found to decrease with increasing N. For monofilament tapes the strain tolerance is 2%–3% strain while for multifilament tapes it decreases to ∼1% at N=3 and ∼0.4% at N=5. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 5 (1989), S. 1326-1331 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 4 (1988), S. 903-906 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 3 (1991), S. 3111-3124 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Fluctuations of magnetic fields and related magnetohydrodynamic (MHD) phenomena are investigated in the TPE-1RM15 reversed-field pinch experiment [Plasma Physics and Controlled Fusion Research, 1986 (IAEA, Vienna, 1987), Vol. 2, p. 453]. Mode analysis of fluctuations measured by multichannel coils reveals that nonlinear interactions between m=1 and m=0 modes, such as nonlinear coupling and phase locking, play significant roles during a dynamo event (i.e., the flux genertion process in the sustainment phase), resulting in transition from an unstable state to a stable state. Behaviors of these fluctuations are found to be toroidally asymmetrical due to strong nonlinearity. Study of the current ramping experiment shows that the inverse of global energy confinement time depends on the squared fluctuation level offset linearly, which is consistent with the prediction of the transport model based on the diffusion of stochastic field lines. By examining the dependence of the resistive part of the loop voltage on the fluctuation level, the input power to the electrons and ions are estimated to be about 70% and 30% of the total input power, respectively.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background We have recently demonstrated that the transfer of interleukin (IL)-5-producing CD4+ T cell clones into unprimed mice is sufficient for the development of eosinophilic inflammation in the bronchial mucosa upon antigen inhalation.Objective The aim of this study was to elucidate the possible contribution of mast cells in eosinophilic inflammation and bronchial hyper-responsiveness (BHR), and to discriminate between the roles of CD4+ T cells and mast cells.Methods Mast cell-deficient mice (WBB6F1-W/Wv) and their congenic normal littermates (WBB6F1−+/+) were immunized with ovalbumin and challenged by inhalation with the relevant antigen.Results Airway eosinophilia was induced with equivalent intensity in +/+ and W/Wv mice 6, 24, 96 and 216 h after antigen inhalation. In contrast, 48 h after antigen challenge, eosinophilic infiltration into the bronchial mucosa was significantly less pronounced in W/Wv mice than in +/+ mice. Anti-CD4 monoclonal antibody (mAb), anti-IL-5 mAb, and cyclosporin A were administered next, demonstrating that the airway eosinophilia of W/Wv mice induced 48 h after antigen challenge was almost completely inhibited by each of these three treatments, but that of +/+ mice was significantly less susceptible. Bronchial responsiveness to acetylcholine was increased 48 h after antigen challenge and was not significantly different between +/+ and W/Wv mice. Administration of anti-IL-5 mAb completely inhibited the development of BHR in both +/+ and W/Wv mice.Conclusion These results indicate that, in mice, mast cells do have a supplemental role in the development of pulmonary eosinophilia but not BHR. CD4+ T cells totally regulate these responses by producing IL-5.
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Atopic asthma is linked to a T-helper type 2 dominated pathogenesis, but there is increasing evidence of Th1/Tc1-mediated processes in the aetiopathology of asthma. Killer-specific secretory protein of 37 kDa (Ksp37) is expressed in cytotoxic lymphocytes, selectively in the effector subsets of CD8+- and CD4+ T lymphocytes and in CD16+/CD56dim natural killer cells and γ/δ T cells. This effector cell-specific expression of Ksp37 and its coexpression with perforin suggest that Ksp37 might be involved in processes mediated by cytotoxic cells.Objective We hypothesize that Ksp37 could indicate the involvement of cytotoxic lymphocytes in the pathogenesis of atopic asthma, and investigated Ksp37 concentration in bronchoalveolar lavage fluid (BALF) collected 10 min, 18, 42 or 162 h after segmental allergen provocation and in serum of patients with atopic asthma (n=25).Methods Ksp37 concentrations in BALF and serum were detected by ELISA. Flow cytometric analysis was used to assess numbers and cell subsets in BALF.Results Ksp37 increased significantly in BALF 10 min, 18 and 42 h, but not 162 h after allergen challenge compared with saline-challenged controls, while Ksp37 serum levels did not change significantly at all time-points. In addition, the increase in Ksp37 concentrations in BALF correlated with the corresponding numbers of lymphocytes.Conclusions We conclude that Ksp37 level increased in BALF 10 min, 18 and 42 h after allergen challenge but not in peripheral blood. Our findings suggest that segmental allergen challenge in asthma is associated with an increase in Ksp37 concentrations in BALF and an influx of potentially cytotoxic T lymphocytes into the lungs.
    Type of Medium: Electronic Resource
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  • 19
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Myxobolus artus infection of carp is reported for the first time from Japan. In most cases, it took the form of interfibrillar pseudocysts in the skeletal muscle, some showing abnormal growth, imperfect encapsulation of the parasite by the host connective tissue and irregular development of the ectoplasm. Such atypical pseudocysts probably ruptured before the completion of sporogenesis, causing lysis of adjacent muscle fibres. Intrafibrillar pseudocysts were also present. After spore formation was complete or atypical pseudocytes were ruptured host reaction was initiated. Spores were phagocytosed and transported to the melanomacrophage centres in the kidney, liver, spleen etc. Phagocytosed spores were also observed in the capillaries and epithelial tissues of various organs, suggesting that the spores were transported there from the skeletal muscle through the host vascular system. They are thought to be discharged from the host through the skin and intestine.
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 43 (1993), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The circulating antibody which reacted with sonicated spores of Myxobolus artus was detected in some naturally infected carp. However, some other fish had no detectable sign of infection, though they had the antibody. When carp were injected either with intact or sonicated spores, the antibody was not produced, while fish injected either with developing stages (presporogonic and sporoblast stages) of the parasite or sonicated spores with bovine serum albumin elicited the antibody production. The results of the injection experiments suggest that (1) developing stages have antigenicity to carp, and (2) spores have lost the antigenicity; sonicated spores are haptens, with which the antibody can react. In an indirect fluorescent antibody technique, sera positive for the antigen reacted with developing stages of the parasite, but not with the spore.The mechanism of the host immune response against M. artus is discussed in relation to a previous observation that the parasite sometimes underwent abnormal development, in which host encapsulation was imperfect or even lacking, probably leading to degeneration of pseudocysts before the completion of spore formation. It is plausible that the antibody was produced when pseudocysts which showed abnormal growth ruptured during their developing stages, resulting in exposure of the young parasite to the host immune system.
    Type of Medium: Electronic Resource
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