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  • 11
    ISSN: 0196-9781
    Keywords: Angiotensin I ; Angiotensin II ; Angiotensin(1-7) ; Blood pressure ; Hypertension ; Renin gene ; Tissue renin-angiotensin system
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nach einseitiger Drosselung der Nierenarterie beim Hund fanden sich höhere Renin-Aktivität und Norepinephrin-Konzentration im Urin der ischämischen Niere als im Urin der Gegenseite. In der Rinde der gedrosselten Niere waren Renin-Aktivität und Granulationsindex der juxtaglomerulären Zellen höher als in der Rinde der ungeklemmten Niere, während der Natriumgehalt niedriger war.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 77 (1999), S. 455-455 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 73 (1995), S. 1-3 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1432-1440
    Keywords: Angiotensin I-converting enzyme ; Gene expression ; Sodium chloride ; Heart ; Inbred rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have recently shown that the angiotensin I converting enzyme (ACE) gene is linked to NaCl-loaded blood pressure in the stroke-prone spontaneously hypertensive rat (SHRSP), and that high-NaCl loading selectively stimulates ACE in the aorta of SHRSP but not in normotensive Wistar-Kyoto (WKY) rats. We therefore investigated the relationship between cardiac ACE and the development of hypertension and left ventricular hypertrophy in response to normal- and high-NaCl diet in these rats. ACE mRNA and ACE activity were measured in left ventricular tissue after completion of hemodynamic characterization of the animals. While SHRSP rats increased blood pressure (P〈0.0001) and heart rate (P〈0.005) in response to high NaCl, blood pressure remained unchanged in WKY. Similarly, relative left ventricular weight increased only in SHRSP after high NaCl (P〈0.002). A significant two- to threefold increase of cardiac ACE mRNA and fourfold stimulation of ACE enzyme activity in response to high NaCl was found in both WKY and SHRSP rats (P〈0.005). The induction of ACE gene expression was significantly more pronounced in SHRSP compared to WKY (P〈0.02), whereas no significant strain differences in left ventricular ACE activity were found after either normal- or high-NaCl diet. Thus, arterial blood pressure and left ventricular weight remained unchanged in the WKY rats despite the activation of left ventricular ACE activity after high-NaCl exposure. These results demonstrate that left ventricular ACE activity is equally upregulated in response to high-NaCl in the normotensive and hypertensive strain, independently from the development of hypertension. We conclude that the pretranslational induction of left ventricular ACE with high-NaCl loading may be important both for the regulation of cardiac angiotensins and kinins and for local therapeutic ACE inhibition in the heart during high-salt status.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 788-792 
    ISSN: 1432-1440
    Keywords: Sodium ; Calcium ; National Health and Nutrition Examination Survey (NHANES) ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The widely accepted recommendation that hypertensive subjects benefit from a reduction of sodium intake has lately been challenged by a number of publications. From one analysis of the First National Health and Nutrition Examination Survey (NHANES) in the USA, the conclusion was reached that hypertension was associated more frequently with low nutritional sodium intake and low calcium intake. Other authors analysing the same data but using different criteria and statistical methods did not confirm such conclusions. The criticisms of epidemiological data concerning the relationship between salt intake and hypertension include frequently inconsistent definition of hypertension, failure to consider methodological uncertainties in the measurement of salt intake and excretion and inadequate control of confounding variables such as age, race, sex, body mass index and lifestyle. The claimed link between nutritional calcium and blood pressure is completely unclear and needs careful investigation. A reduction of sodium intake from the present day excessive amounts to moderate intakes of 3–6 g per day is still recommended in order to prevent the establishment of high blood pressure, to reduce hypertensive blood pressure levels or to reduce the doses of antihypertensive drugs. With mild hypertension being the main problem of high blood pressure management, further research is necessary to place dietary intervention in the non-pharmacological treatment of hypertension on a firmer, more rational footing.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 46 (1993), S. 487-509 
    ISSN: 0167-0115
    Keywords: Angiotensin II ; Angiotensin II receptor ; Angiotensin-converting enzyme ; Angiotensinogen ; Renin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 53 (1994), S. 145 
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 184 (1984), S. 171-178 
    ISSN: 1433-8580
    Keywords: Endogenous opioid peptides ; β-Endorphin ; Enkephalins ; Naloxone ; Hemorrhagic hypotension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixteen anesthetized foxhounds were instrumented for hemodynamic measurements. The adrenolumbar vein was cannulated, and hemorrhagic hypotension (MAP=40 mmHg for 3 h) was induced by bleeding. The plasma levels ofβ-endorphin (β-END), methionine-enkephalin (M-ENK), and leucine-enkephalin (L-ENK) were determined in systemic and adrenal venous blood by specific RIA. Five dogs received an i.v. bolus of naloxone (2 mg/kg) and a subsequent naloxone infusion of 2 mg/kg per hour 1 h after onset of hypovolemia. Eleven dogs served as controls and received equivalent volumes (1 ml/kg per hour) of saline. Hemorrhage resulted in a sharp increase in plasma concentrations of all measured opioid peptides, particularly of M-ENK (26-fold) and L-ENK (24-fold) in the adrenal effluent. Systemicβ-END levels remained 3-fold increased, whereas the ENK release decreased spontaneously. Naloxone treatment inhibited the spontaneous fall of adrenal ENK release during the hypotensive phase; the ENK values remained elevated 20- to 35-fold. Reinfusion of the autologous blood resulted in a normalization of the concentrations of all peptides in both groups. These data demonstrate that hemorrhagic hypotension will cause stimulation of release of endogenous opioid peptides. The high levels of ENK in the adrenal effluent indicate that the adrenal gland is the main source of these peptides in the circulation. In addition toβ-END, the ENK have therefore to be considered as possible factors perpetuating circulatory shock.
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure1–7. Linkage studies in ...
    Type of Medium: Electronic Resource
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