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  • 2000-2004  (13)
  • 1990-1994  (21)
  • 1940-1944  (10)
  • 1915-1919  (1)
  • 1900-1904  (2)
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  • 11
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background : Symptom relief, through adherence to appropriate maintenance therapy, is the sole objective of treatment for patients with endoscopy-negative gastro-oesophageal reflux disease.Aim : To compare the efficacy of ‘on-demand’ treatment with esomeprazole 20 mg vs. continuous treatment with lansoprazole 15 mg daily in patients with endoscopy-negative gastro-oesophageal reflux disease.Methods : Endoscopy-negative gastro-oesophageal reflux disease patients who achieved complete resolution of heartburn after short-term (2–4 weeks) treatment with esomeprazole 20 mg (n = 774) were randomized to receive either esomeprazole 20 mg on-demand (n =311) or lansoprazole 15 mg continuous daily treatment (n = 311) for 6 months.Results : Significantly more patients were willing to continue taking esomeprazole on-demand than lansoprazole continuous therapy after 6 months (93% vs. 88%; P = 0.02). This superior outcome was achieved despite patients on esomeprazole requiring medication only 38% as often as those on lansoprazole, leading to direct cost savings of more than one-third (36%). Furthermore, patients receiving esomeprazole 20 mg on-demand were more satisfied with their treatment after 1 month compared with patients taking lansoprazole 15 mg continuously.Conclusions : In patients with endoscopy-negative gastro-oesophageal reflux disease, esomeprazole 20 mg on-demand is more acceptable to patients and is an economically more effective treatment than lansoprazole 15 mg continuously.
    Materialart: Digitale Medien
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  • 12
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background : Alverine citrate has been used in the treatment of irritable bowel syndrome for many years.Aims : To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for 12 weeks.Methods : One hundred and seven patients with irritable bowel syndrome were entered into this three-centre, double-blind, randomized, placebo-controlled, parallel group trial. The primary end-point was relief of abdominal pain indicated by improvement in the scores for severity and frequency. Secondary efficacy variables included scores for other clinical symptoms and for overall well-being.Results : The severity and frequency of abdominal pain improved in 66% and 68% of patients treated with alverine citrate vs. 58% and 69% of the placebo group, but these differences were not significant. The mean percentage reduction in the scores for abdominal pain from baseline to the final assessment, although greater in the alverine citrate group (43.7%) compared with the placebo group (33.3%), was not statistically significant.Conclusions : Alverine citrate is no better than placebo at relieving the symptoms of irritable bowel syndrome. Future trials should be designed to take into account the high and persistent placebo response seen in this condition.
    Materialart: Digitale Medien
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  • 13
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary Background Bowen's disease (BD; intraepithelial squamous cell carcinoma) is therapeutically challenging because lesions, which may be multiple, are frequently located at sites that heal poorly. There is a small risk of progression to invasive carcinoma. Photodynamic therapy (PDT) is an effective treatment for certain non melanoma skin cancers, but comparison studies with other, better-established therapies are limited. Objectives To compare the efficacy and tolerability of PDT and topical 5-fluorouracil (5-FU) in BD. Methods Forty patients from two centres were randomized to either topical PDT or 5-FU. The PDT group was treated with 20% 5-aminolaevulinic acid (ALA) applied 4 h before illumination with 100 J cm−2 narrowband red light (630 ± 15 nm). 5-FU was applied to lesions for 4 weeks. A repeat treatment cycle was performed after 6 weeks if required. Results Twenty-nine of 33 (88%) lesions treated with PDT initially responded completely, compared with 22 of 33 (67%) after 5-FU. After 12 months, two recurrences in the PDT group and six in the 5-FU group reduced complete clinical clearance rates to 82% and 48%, respectively. PDT was significantly more effective (P = 0·006, odds ratio 4·78, 95% confidence interval 1·56–14·62). In the 5-FU group, severe eczematous reactions developed around seven lesions, ulceration in three and erosions in two. No such reactions occurred following PDT. There was no difference in overall pain experienced during each therapy. Conclusions Topical ALA-PDT is more effective than topical 5-FU in the treatment of BD, with fewer adverse events. ALA-PDT should be considered one of the first-line therapeutic options for BD.
    Materialart: Digitale Medien
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  • 14
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 94 (1915), S. 589-589 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] THE accompanying photograph (Fig. 1) represents the side of a steel bar. The bar was first marked by a punch in the way shown, and the punch marks were afterwards completely filed out. The side was then polished and the bar pulled in a testing machine beyond the elastic limit of the material. ...
    Materialart: Digitale Medien
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  • 15
    Digitale Medien
    Digitale Medien
    Springer
    Diseases of the colon & rectum 34 (1991), S. 827-828 
    ISSN: 1530-0358
    Schlagwort(e): Gallbladder ; Carcinoma ; Ulcerative colitis ; Primary sclerosing cholangitis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The authors present the cases of two patients with carcinoma of the gallbladder complicating chronic ulcerative colitis. Both patients had concomitant primary sclerosing cholangitis. Twelve such cases of gallbladder carcinoma have been reported in the literature. The presence of primary sclerosing cholangitis in patients with ulcerative colitis is associated with malignancy of the extrahepatic biliary tree. It is suggested that, if colectomy is necessary, the liver should be biopsied and a cholecystectomy performed if the gallbladder is deemed abnormal.
    Materialart: Digitale Medien
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  • 16
    Digitale Medien
    Digitale Medien
    Springer
    Entomologia experimentalis et applicata 73 (1994), S. 255-264 
    ISSN: 1570-7458
    Schlagwort(e): grasshopper ; monophagy ; polyphagy ; Simmondsia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The feeding behavior of different populations of the grasshopper,Schistocerca shoshone, was investigated in the southwestern United States. Insects from three riparian populations, with a broad spectrum of plants available to them, tended to eat plants roughly in relation to their availability except that broad-leaved herbaceous plants were avoided. Insects from a desert population in a plantation ofSimmondsia fed exclusively on that plant, as did those from another population in the Tucson mountains, despite the availability of a range of other plants. Insects from a third desert population, near Portal, fed mainly onProsopis, the dominant woody plant. In detailed behavioral experiments in the laboratory, insects from Tucson mountains readily acceptedSimmondsia, and less readily acceptedProsopis. Three other common woody plants from the habitat were generally rejected without feeding. Insects from Portal acceptedProsopis andSimmondsia with approximately equal readiness. Breeding experiments suggested that the differences between the plantation insects and those from Portal was genetic and not induced by experience. The insects from both populations were potentially polyphagous and ate a wide range of plants in the laboratory if given no alternative.
    Materialart: Digitale Medien
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  • 17
    Digitale Medien
    Digitale Medien
    Springer
    Entomologia experimentalis et applicata 71 (1994), S. 145-153 
    ISSN: 1570-7458
    Schlagwort(e): fluvalinate ; pyrethroids ; spider mites ; Tetranychus urticae ; behaviour ; sub-lethal effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Residual deposits of fluvalinate caused two-spotted spider mite,Tetranychus urticae Koch, dispersal by running off (run-off) and spinning down (spin-down) from treated leaves. Run-off occured at concentrations from 0.0005 g a.i. 1−1 and reached a peak at 0.01 g a.i. 1−1. Spin-down was more predominant at concentrations above 0.01 g a.i. 1−1. Spin-down and run-off proportions varied with fluvalinate formulation. Oviposition was temporarily suppressed on fluvalinate-treated leaves, presumably because of an irritant effect which reduced feeding. An emulsifiable concentrate formulation caused the largest reductions in oviposition. Oviposition returned to the level exhibited by untreated mites two days after removal from treated surfaces. Oviposition and feeding were positively correlated and both declined reciprocally with increasing fluvalinate concentration.
    Materialart: Digitale Medien
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  • 18
    Digitale Medien
    Digitale Medien
    Springer
    Journal of insect behavior 6 (1993), S. 79-91 
    ISSN: 1572-8889
    Schlagwort(e): associative learning ; grasshopper ; palpation ; plant surface
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The behavioral responses of final-instar nymphs of Schistocerca americanato a variety of acceptable and unacceptable plants were recorded. Palpation occurred on all plants and the palps are involved in both acceptance and rejection. On most unacceptable plants, rejection was at first dependent on biting the leaf, but subsequently on Lantana, Machaeranthera, Moms,and Physalis,rejection often occurred after palpation of the surface alone. This is consistent with the suggestion that associative learning occurs. This response did not wane even when the insects had been without food for over 2 h. There was also some evidence of an innate response to the surface characteristics of Physalis.The features of the surfaces that produced these responses were not determined.
    Materialart: Digitale Medien
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  • 19
    ISSN: 1572-8889
    Schlagwort(e): development ; food aversion learning ; grasshopper ; habituation ; plant acceptability ; polyphagy ; survival
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The feeding behavior of final-instar nymphs ofSchistocerca americana was observed when they first encountered plants that ranged in acceptability from being eaten in large amounts to not being eaten at all. Growth and survival on the same plants through the last stadium were also studied and the results combined as a suitability index to facilitate comparison with the behavior. Although the plants that were eaten most gave the highest suitability index and those that were not eaten permitted no survival, there was no simple relationship between the amounts eaten and the suitability for growth and survival. The possibility that the insects might become habituated to plants that were initially unacceptable was investigated, but no habituation was found over a 3-day period. It is suggested that food intake is largely determined by the presence of deterrent compounds in the less acceptable foods and that nutritional differences between the plants are likely to have been of minor importance. The behavior on some foods suggests that food aversion learning may be involved. It is concluded that the variability of the insects' behavior makes it impossible to predict the suitability of a plant from their immediate behavioral responses. In the field, insects may sometimes reject foods that would be suitable for survival and development, and feed on plants that are nutritionally deficient or even toxic.
    Materialart: Digitale Medien
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  • 20
    ISSN: 1434-601X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract. The highly sensitive GASP array at the INFN Legnaro Laboratory was used to study the $\gamma$ -ray de-excitation of neutron-rich nuclei produced in the deep-inelastic processes which occur when 230 MeV 36S ions interact with a target of 176Yb. Yrast decay schemes were identified in over forty target-like fragments and in over twenty projectile-like fragments. Analysis of the data has resulted in extensions to the yrast decay sequences of the target-like species, 176Hf, 166Er, 172Yb, and 152Sm. New transitions have also been observed in a number of projectile-like species including 34P and 41Cl. Experimental results are compared with the results of shell model calculations.
    Materialart: Digitale Medien
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