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  • 11
    Electronic Resource
    Electronic Resource
    Effect of antihypertensive formulation on health service expenditures (1993)
    Springer
    Clinical autonomic research 3 (1993), S. 363-368 
    Details
    ISSN: 1619-1560
    Keywords: Compliance ; Health care expenditures ; Health policy ; Hypertension ; Medicaid ; Pharmaceutical formulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A Major barrier to the management of hypertension is the extent to which patients comply with the treatment regimen. Herein we report the findings of a retrospective analysis designed to discern the relationship between antihypertensive formulation, regimen compliance and the utilization of health care services. Data for this analysis were derived from the state of South Carolina's Medicaid computer archive. The study population consisted of 1 000 randomly selected beneficiaries initially prescribed one of the following antihypertensive regimens as monotheraphy: atenolol (daily); captopril (twice daily); oral clonidine (twice daily); transdermal clonidine (once a week); diltiazem (twice daily); enalapril (twice daily); metoprolol (twice daily); prazosin (twice daily); terazosin (daily); and verapamil-SR (daily). Multivariate regression analysis was used to determine the incremental influence of selected demographic characteristics, utilization of medical services prior to diagnosis for hypertension, initial antihypertensive medication, medication possession ratio for antihypertensive therapy, and the number of maintenance medications for disease state processes other than hypertension on post-period health care expenditure. Results indicate that patients initially prescribed antihypertensive medication requiring daily or weekly administration experience infrequent changes in their therapeutic regimen, far less use of concomitant therapy for blood pressure control, an increased utilization of antihypertensive medication, and a decrease in the use and cost of physician, hospital and laboratory services.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01829454
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  • 12
    Electronic Resource
    Electronic Resource
    Evaluation of thin layer chromatography—Fast atom bombardment mass spectrometry: Application to the determination of midazolam intoxication by use of 3-glycidoxypropyl-treated thin layer chromatographic plates (1993)
    Springer
    Chromatographia 36 (1993), S. 293-296 
    Details
    ISSN: 1612-1112
    Keywords: Thin layer chromatography ; Fast atom bombardment mass spectrometry ; TLC/FABMS ; 3-Glycidoxypropyldimethylethoxysilane treated TLC plate ; Midazolam intoxication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The effectiveness of 3-glycidoxypropyl-treated thin layer chromatographic plates in the determination of midazolam intoxication has been studied by thin layer chromatography/fast atom bombardment mass spectrometry. Silica plates treated with 3-glycidoxypropyldimethylethoxysilane were used for the measurement of their physical composition and for chemical analysis. From elemental carbon analysis data, the maximum number of bonded 3-glycidoxypropyl surface groups per gram was calculated to be 0.417×1021. Midazolam in human serum from patients suffering from intoxication could be separated on a 3-glycidoxypropyl-treated thin layer chromatographic plate with chloroform as eluent. After applying the technique of diffused spot condensation on the 3-glycidoxypropyl-treated thin layer chromatographic plate, the established thin layer chromatography/fast atom bombardment mass spectrometry method was used for the identification of midazolam intoxication, and improved the detection limit for midazolam in the serum of an intoxication patient by 30 times.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02263880
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  • 13
    Electronic Resource
    Electronic Resource
    Preparation of octadecyl modified column gels using heat-treated silicas and their retention behaviour in high-performance liquid chromatography (1992)
    Springer
    Chromatographia 33 (1992), S. 203-207 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Octadecyl modified silica ; Hexamethyldisilazane treated silica ; Calcination ; Heat-treated silica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The effect of silanol groups on three types of octadecylmodified column gels using heat-treated silicas by calcination has been studied by high-performance liquid chromatography. After heat-treating at 180°C, 500°C and 950°C, the silicas treated with octadecyldimethylchlorosilane were used for the measurement of physical and chemical analysis. From elemental carbon analysis data, the reactive silanol group concentrations, αOH(s), were determined to be 2.0 in the 180°C treated silica, 2.1 in the 500°C treated silica and 1.6 in the 950°C treated silica, respectively (original silica: mean pore diameter 116 Å, specific surface area 298 m2/g, pore volume 1.22 ml/g, particle size 5.0 μm). The separation factors, α, of pyridine versus phenol were measured to be 0.79 on 180°C treated silica, 0.91 on 500°C treated silica and 1.98 on 950°C treated silica, using acetonitrile-water mixtures as the eluent. And then, on the basis of the physico-chemical and chromatographic data, the three types of octadecyl modified column gels using heat-treated silicas by calcination have been compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02276183
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  • 14
    Electronic Resource
    Electronic Resource
    Surface modification by calcium ions—Effect on chromatographic properties of silica (1994)
    Springer
    Chromatographia 39 (1994), S. 29-34 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Calcium modified silica ; Calcium adsorption isotherms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The modification of silica surfaces by calcium ions has been studied by high-performance liquid chromatography. After treatment at pH 7.0 and 9.0 with calcium hydroxide, the modified silicas were characterised by physical and chemical analysis. From measurements by atomic absorption, the amount of calcium adsorbed was 650 ppm on silica modified at pH 7.0, and 4800 ppm on silica modified at pH 9.0. The amount of calcium on the modified silica was 0.574 groups nm−2 at pH 9.0 (original silica: mean pore diameter 176 Å, specific surface 279 m2 g−1, pore volume 1.23 ml g−1, mean particle size 9.8 μm). On the other hand, the amount of calcium in the original silica was 58 ppm. The separation factor, α for N-methylaniline and N,N-dimethylaniline was 5.2 on silica modified at pH 9.0, but could not be measured on silica modified at pH 7.0 and the original silica, using iso-propyl alcohol—n-hexane (0.5∶99.5) eluent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02320454
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  • 15
    Electronic Resource
    Electronic Resource
    Growth of a Japanese isolate ofTaenia crassiceps in intermediate and definitive hosts (1990)
    Springer
    Parasitology research 76 (1990), S. 351-354 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Higher infection rates were observed in gerbils and voles than in ICR mice after oral inoculation with eggs of a Japanese isolate ofTaenia crassiceps. Asexual reproduction ofT. crassiceps cysticerci was observed in all gerbils and voles infected i.p. with the cysticerci. However, ICR mice and Wistar rats were not suitable for the asexual proliferation ofT. crassiceps. The hooks of cysticerci from mice were smaller than those from gerbils. In experimentally infected puppies, parasite development was noted as follows: strobilation and initial differentiation of the genital primordia on day 7 postinoculation (p.i.), appearance of the testes on day 9, observation of the ovaries on day 10, and development of the lateral branches of the uterus on day 15. The prepatent period was 27–31 days. After day 15 p.i., most of the worms were recovered from the middle third of the small intestine. The number of proglottids shed per day by each strobila was about 1. The number of eggs contained in a gravid segment was about 13000.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00928191
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