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  • Articles: DFG German National Licenses  (16)
  • 1985-1989  (16)
  • 11
    Electronic Resource
    Electronic Resource
    Nuclear design of a heliotron-H fusion power reactor (1985)
    Springer
    Journal of fusion energy 4 (1985), S. 45-55 
    Details
    ISSN: 1572-9591
    Keywords: heliotron-H ; blanket ; shield ; superconducting magnet ; tritium breeding ratio ; atomic displacement ; dose rate ; shutdown ; Monte Carlo calculation ; THIDA code system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Nuclear analysis was carried out for the heliotron-H fusion power reactor employing anl=2 helical heliotron field. The neutronics aspects examined were (a) tritium breeding capability, (b) shielding effectiveness for the superconducting magnet (SCM), and (c) induced activity after shutdown. In this reactor design of the heliotron-H, the space available for the blanket and shield is limited due to the reactor geometry. Thus, some parametric survey calculations were performed to satisfy the design requirements. The nucleonic design features of the heliotron-H are as follows. An adequate tritium breeding ratio of 1.17 is obtained when a 10-cm thick Pb neutron multiplier and a 40-cm thick Li2O breeding blanket are used. In this case, the total nuclear energy deposition is 16.10 MeV per 14.06 MeV incident neutron. The performance of the SCM is assured during ∼2 yr of continuous operation using a 20-cm thick tungsten shield. Biological dose rate behind the SCM at 1 day after shutdown is too high for hands-on maintenance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01051638
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Effect of retinoic acid on the replication of human immunodeficiency virus in HTLV-I-positive MT-4 cells (1987)
    Springer
    Medical microbiology and immunology 176 (1987), S. 189-198 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inhibitory effect of all-trans-retinoic acid (RA) on human immunodeficiency virus (HIV) replication upon infection was studied quantitatively using a novel bioassay system with a HTLV-I-carrying human T-cell line, MT-4. The results can be summarized as follows. (1) The appearance of HIV antigen was significantly reduced when the cells were treated with more than 1 μg/ml of the chemical after infection. When HIV specific plaque assay was performed to titrate the virus from the supernatant of culture treated with 10 μg/ml of RA no plaques were observed. (2) When RA was applied directly in the plaque assay, significant decrease of the number of plaques was discerned showing 68, 66, 47 and 16, at doses of 0.1, 1, 5, and 10 μg/ml of RA, while 102 plaques were formed in the control dish. (3) The appearance of cytopathic effects of MT-4 cells by HIV was more delayed in RA-treated cultures than in untreated cultures. (4) Concomitant treatment of the cells with 5 μg/ml of RA and various concentrations of suramin resulted in the more effective inhibition of HIV replication than suramin alone. (5) RA did not inhibit the reverse transcriptase activity (RT) of HIV directly. These data suggest that RA inhibits HIV replication by inducing an antiviral state in the cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196686
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Inhibition (in vitro) of replication and of the cytopathic effect of human immunodeficiency virus by an extract of the culture medium of Lentinus edodes mycelia (1988)
    Springer
    Medical microbiology and immunology 177 (1988), S. 235-244 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An extract of culture medium of Lentinus edodes mycelia (LEM) was prepared. This was further fractionated by 50% ethanol precipitation and both the resulting product, E-P-LEM, and LEM were studied to evaluate their effect on the activity of human immunodeficiency virus (HIV) in vitro. The experiments were performed using either a cell-free infection system with MT-4 cells, or a cell-to-cell infection system with MOLT-4 cells, which induces multinucleated giant cells very efficiently. E-P-LEM almost completely blocked both the cytopathic effect of giant cell formation and specific antigen expression due to HIV, whereas LEM before ethanol precipitation blocked the expression of HIV antigen in MT-4 cells only at a high concentration. Pretreatment of the virus with E-P-LEM before infection blocked HIV infection in the target cells. Thus, the inhibitory effect of LEM and E-P-LEM on HIV could be due to a blocking of the initial stages of HIV infection. Moreover, reverse transcriptase activity of avian myeloblastosis virus was inhibited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189409
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    Paper (German National Licenses)
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  • 14
    Electronic Resource
    Electronic Resource
    Antiretroviral activity in a marine red alga: reverse transcriptase inhibition by an aqueous extract of Schizymenia pacifica (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 413-416 
    Details
    ISSN: 1432-1335
    Keywords: Antiretroviral activity ; Marine algae ; Avian myeloblastosis virus ; Reverse transcriptase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An aqueous extract from the marine red alga, Schizymenia pacifica has been tested in a cell free system for its effect on reverse transcriptase from avian retrovirus (avian myeloblastosis virus), and mammalian retrovirus (Rauscher murine leukemia virus). The extract inhibited reverse transcriptase from both these retroviruses but showed almost no effect, if any, on the activity of cellular DNA polymerase alpha and RNA polymerase II in vitro. Consequently it is unlikely to have an adverse effect on the growth of cultured cell. The inhibitory activity of the extract was stable over a relatively wide pH range (pH 1–11) and was not lost after pronase digestion. Inhibitory activity of the extract was lost after boiling at 100°C in 0.67 N HCl, and after treatment with 100 mM NaIO4. The active principle in the extract has an apparent molecular weight in excess of 100 000 daltons. This new reverse transcriptase inhibitor is probably a polysaccharide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390034
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    Paper (German National Licenses)
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  • 15
    Electronic Resource
    Electronic Resource
    The outcome of severe head injuries in children (1989)
    Springer
    Neurosurgical review 12 (1989), S. 436-440 
    Details
    ISSN: 1437-2320
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01790687
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    Paper (German National Licenses)
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  • 16
    Electronic Resource
    Electronic Resource
    Nuclear analysis of a laser fusion reactor, SENRI-I (1985)
    Springer
    Journal of fusion energy 4 (1985), S. 289-314 
    Details
    ISSN: 1572-9591
    Keywords: SENRI-I ; pellet ; blanket ; tritium breeding ratio ; energy deposition ; radiation damage ; activity ; streaming
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A neutronic analysis of the laser-driven inertial-confinement fusion reactor SENRI-I is presented. Three-dimensional Monte Carlo calculations were performed to examine the effects of laser beam ports on the flux distribution, tritium breeding ratio, thermal energy deposition in the blanket, and radiation streaming. A Monte Carlo code was also used for the time-dependent radiation-damage analysis accounting for the time of the flight spread of neutrons and the results are compared to the analysis for the HIBALL design. Induced radioactivity was estimated, based on the one-dimensional transport calculation and depletion analysis. The calculated results reveal the advantages of the SENRI-I design with a thick Li layer compared to other reactor systems employing a dry-wall scheme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01053360
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    Paper (German National Licenses)
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