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  • 2000-2004  (5)
  • 1975-1979  (10)
  • 1960-1964  (10)
  • 11
    Digitale Medien
    Digitale Medien
    HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP) (2002)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 29 (2002), S. 0 
    Details
    ISSN: 1600-051X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background/Aim:  There is growing indication that differences in host response determine susceptibility and resistance to periodontal disease. Particularly, the effect of histocompatibility antigens (HLA) on early onset periodontitis (EOP) has been studied. As most of the results are not conclusive and to date no report has been done on German patients, the aim of this study was to investigate the distribution of HLA alleles in a group of 50 German RPP patients and 102 German AP patients and to compare them to 102 control probands without periodontitis.Methods:  Diagnosis was established according to standardised clinical criteria. HLA typing was performed using serologic and molecular biologic (PCR-SSP) techniques.Results: Compared to the controls, RPP patients had a significantly higher frequency of HLA-DRB1*13 and a significantly lower frequency of HLA-DRBblank*(non-DRB3/4/5). AP patients showed a significantly increased occurrence of HLA-B*14 and -Cw*08 as well as a significantly decreased frequency of HLA-A*03. In both patient groups HLA-A*11 and -A*29 had an increased frequency and HLA-A*31 and -A*30/31 were decreased. These differences were statistical significant in the whole patient group (RPP + AP).Conclusions:  Based on modern DNA techniques the present study shows an association of HLA to both RPP and AP. Certain HLA alleles seem to be associated with susceptibility or resistance to periodontitis in general. However, before this knowledge can be used for differential diagnosis or prognosis, further investigations are necessary.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1034/j.1600-051X.2002.290614.x
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  • 12
    Digitale Medien
    Digitale Medien
    Cleavage site of bacteriophage fd gene II-protein in the origin of viral strand replication (1979)
    [s.l.] : Nature Publishing Group
    Nature 278 (1979), S. 365-367 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Gene Il-protein was purified from Escherichia coli cells '? ? WIthPhaSe fd mutan* in gene V using the stimulation of DNA synthesis on fd RFI as an assay. The purification steps were ammonium sulphate precipitation and various columns Details of the isolation procedure will be published ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/278365a0
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  • 13
    Digitale Medien
    Digitale Medien
    Separation and specificity of action of four morphogens from hydra (1979)
    Springer
    Development genes and evolution 186 (1979), S. 139-149 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Hydra ; Morphogenetic substances ; Regeneration ; Budding
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary A procedure is presented by which four previously described morphogenetic substances can be purified from hydra: an activator and an inhibitor of head formation and an activator and an inhibitor of foot formation. We show that all four substances act specifically. At low concentrations, the head factors only influence head and not foot formation, and the foot factors only influence foot and not head formation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00848175
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  • 14
    Digitale Medien
    Digitale Medien
    Head regeneration inHydra is initiated release of head activator and inhibitor (1976)
    Springer
    Development genes and evolution 180 (1976), S. 287-295 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Hydra ; Head regeneration ; Morphogenetic substances
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Hydra regenerating heads release at least two substances into the surrounding medium: one stimulates and one inhibits head formation. The inhibitor is released mainly during the first hour after cutting, the activator is released more slowly with a maximum in the second hour and with substantial release still during the following six hours. The release of both substances seems to be specific for head regeneration: it is not found in animals regenerating feet. The sequential release of these substances leads to the early changes observed at the cellular level during head regeneration inhydra: the inhibitor produces a decrease, the activator an increase in the mitotic activity of interstitial and epithelial cells, if assayed on intact animals. Head regeneration is blocked, if the release of the head activator is prevented. It is therefore suggested that these substances are necessary to initiate head regeneration inhydra.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00848775
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  • 15
    Digitale Medien
    Digitale Medien
    Analysis of morphogenetic mutants of hydra (1977)
    Springer
    Development genes and evolution 183 (1977), S. 193-206 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Hydra mutant ; Morphogenetic substances ; Head formation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary A mutant ofHydra attenuata is analysed, theaberrant, which is distinct from the wild type in having a smaller head with fewer tentacles and only half the number of head-specific cells. The rate of head and foot regeneration and the doubling time are slower inaberrants than in normal hydra. The lower head-forming potential is paralleled by a reduced concentration of head-specific morphogens: compared to the wild type, in theaberrant the concentration of head activator is reduced to 70% in the head and to 50% in the body, the concentration of head inhibitor is reduced to 50% in the head and to 80% in the body. Theaberrant is more sensitive (3 times) to added head activator and less sensitive (〉5 times) to added head inhibitor than the wild type. The slower rate of foot regeneration is paralleled by a lower content of foot-specific morphogens: compared to the wild type, in theaberrant the foot activator is reduced to 40% and the foot inhibitor to 70%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00867320
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  • 16
    Digitale Medien
    Digitale Medien
    Analysis of morphogenetic mutants of hydra (1977)
    Springer
    Development genes and evolution 183 (1977), S. 207-214 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Hydra mutant ; Morphogenetic substances ; Bud formation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Non-budding mutants ofChlorohydra viridissima regenerate heads 6 h faster thanHydra attenuata and the number of tentacles per head is higher. The polarity in pieces from the gastric region is the more labile, the smaller the pieces are. In regenerates heads and tentacles form much more frequently than feet, giving rise to bipolar or multiheaded structures. Buds very seldom form under normal conditions, but they occasionally occur in regenerating animals with two cut surfaces. The higher head-forming potential in the mutant is paralleled by a higher head-activator concentration (20-fold in head, 4-fold in body), than inHydra attenuata, which is not accompanied by an equivalent increase in head-inhibitor concentration (1.4-fold in head, 2-fold in body). The foot-activator concentration is slightly reduced (1.3-fold), the foot-inhibitor concentration is higher (1.6-fold) than inH. attenuata. The mutant is extremely insensitive to head activator, relatively insensitive to head inhibitor and foot inhibitor, but sensitive to foot activator.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00867321
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  • 17
    Digitale Medien
    Digitale Medien
    Analysis of morphogenetic mutants of hydra (1977)
    Springer
    Development genes and evolution 183 (1977), S. 215-222 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Hydra mutants ; Morphogenetic substances ; Size regulation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Minis have a doubling time of 2.4 days,maxis of 8 days.Minis regenerate head and foot 5 h faster thanmaxis.Minis have fewer tentacles (4.6) per head thanmaxis (6.1). Inmini the concentration of the head activator is equal to that inHydraattenuata, but the concentration of the head inhibitor is reduced (2-fold in the head, 1.2-fold in the body). The concentrations of the foot factors are normal.Minis respond likeHydra attenuata to head activator, foot activator and foot inhibitor, but they are less sensitive to head inhibitor Inmaxi the concentration of the head activator is higher than inmini (5-fold in the head, 10-fold in the body) and that of the head inhibitor is also higher (4-fold in the head, 5-fold in the body). The concentration of the foot inhibitor is normal, that of the foot activator is doubled.Maxis are insensitive to added head activator and less sensitive to added head inhibitor and foot inhibitor. Their response to foot activator is normal.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00867322
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  • 18
    Digitale Medien
    Digitale Medien
    Morphogenetic substances in nerve-depletedhydra (1979)
    Springer
    Development genes and evolution 187 (1979), S. 323-328 
    Details
    ISSN: 1432-041X
    Schlagwort(e): Nerve-depletedhydra ; Morphogenetic substances
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary By a double colchicine treatment the nerve-cell population ofhydra was reduced to less than 1% of the normal complement. Such severely nerve-depletedhydra contained normal or higher than normal concentrations of head activator, head inhibitor, foot activator and foot inhibitor which in normal animals are produced by nerve cells. According to typical chromatographic properties all four morphogenetic substances were chemically identical to those found in normal animals. It is suggested that in nervedepletedhydra the epithelial cells, as the only remaining cell type, have taken over the morphogen-producing function of nerve cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00848467
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  • 19
    Digitale Medien
    Digitale Medien
    Immune Escape by Hepatitis B Viruses (2000)
    Springer
    Virus genes 21 (2000), S. 27-37 
    Details
    ISSN: 1572-994X
    Schlagwort(e): HBV ; infection ; liver ; hepadnaviruses
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Hepatitis B viruses are DNA viruses characterized by their very small genome size and their unique replication via reverse transcription. The circular genome has been efficiently exploited, thereby limiting genome variation, and leaves no space for genes in addition to those essentially needed during the viral live cycle. Hepatitis B viruses are prototype non-cytopathic viruses causing persistent infection. Human hepatitis B virus (HBV), as well as the closely related animal viruses, most frequently are transmitted vertically from mothers to their offspring. Because infection usually persists for many years, if not lifelong, hepatitis B viruses need efficient mechanisms to hide from the immune response of the host. To escape the immune response, they exploit different strategies. Firstly, they use their structural and non-structural proteins multiplely. One of the purposes is to alter the immune response. Secondly, they replicate by establishing a pool of stable extrachromosomal transcription templates, which allow the virus to react sensitively to changes in its microenvironment by up- or downregulating gene expression. Thirdly, hepatitis B viruses replicate in the liver which is an immunopriviledged site.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008128212380
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  • 20
    Digitale Medien
    Digitale Medien
    Entmischungserscheinungen in PdB-Legierungen (1977)
    Springer
    Colloid & polymer science 255 (1977), S. 925-925 
    Details
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01617104
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