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  • 11
    Electronic Resource
    Electronic Resource
    Is screening of blood donors for anti-HBc useful? (1990)
    Springer
    Annals of hematology 60 (1990), S. 352-353 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737851
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  • 12
    Electronic Resource
    Electronic Resource
    No evidence for neoantigens in human plasma after photochemical virus inactivation (1992)
    Springer
    Annals of hematology 65 (1992), S. 224-228 
    Details
    ISSN: 1432-0584
    Keywords: Photochemical virus inactivation ; Phenothiazine dyes ; Human fresh plasma ; Neoantigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Photodynamic virus inactivation of human fresh plasma mediated by visible light in the presence of the phenothiazine dyes methylene blue or toluidine blue was investigated to determine whether it influences functional, structural, and immunological properties of plasma proteins. The activities of the coagulation factors I, VIII, IX, X, and XI were affected to a certain degree, while those of most other plasma proteins were not. The elution profiles obtained by ion exchange chromatography of untreated and photodynamically treated plasma were almost identical. Using a number of antisera against human plasma and single plasma proteins, different immunochemical techniques revealed identical patterns for untreated and treated plasma. Thus, there was no indication that the photodynamic virus inactivation procedure applied considerably influences the properties of plasma proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703949
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  • 13
    Electronic Resource
    Electronic Resource
    Hautwellenlängen und dynamischer Scherelastizitätskoeffizient der menschlichen Körperoberfläche bei Vibrationen mit 50 Hz (1955)
    Springer
    Pflügers Archiv 260 (1955), S. 274-291 
    Details
    ISSN: 1432-2013
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364168
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  • 14
    Electronic Resource
    Electronic Resource
    In vitro activity of the new semi-synthetic polypeptide cilofungin (LY121019) againstAspergillus andCandida species (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 697-699 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The in vitro activity of cilofungin (LY121019), a new semi-synthetic antifungal agent was evaluated. Potent activity was seen againstCandida albicans andCandida tropicalis, with almost identical MIC and MFC results, whereas no activity was seen against any isolates ofCandida parapsilosis or threeAspergillus spp. However, MICs were dependent on medium and test conditions chosen. It is concluded that cilofungin has good activity against some medically important yeasts in vitro, and that its in vitro activity depends on the method used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964276
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  • 15
    Electronic Resource
    Electronic Resource
    Bluteiweißveränderungen bei Frankturen (1958)
    Springer
    Langenbeck's archives of surgery 286 (1958), S. 554-563 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei Frakturen gibt es typische Eiweißveränderungen, die aber nicht eine spezifische Reaktion für den Knochenbruch darstellen, sondern auch bei anderen Erkrankungen dieselben Ergebnisse zeigen. Bei unseren Versuchen wurden nach dem Vorbild der Konstellationstypen vonWunderly die Serumeiweißverhältnisse durch die Gesamteiweißbestimmung und durch die Papierelektrophorese bestimmt. Die Labilitätsproben wurden nachTakata, Weltmann und mit der Blutsenkungsreaktion ausgeführt. Die Elektrophoreseuntersuchungen zeigten am Unfalltag Normalwerte. 6 Tage nachher fand sich eine Vermehrung der Globulinfraktion, vor allem der α2-Komponente. Die Albumine waren verringert. Nach 3 Wochen waren die Albumine wieder zur Norm zurückgekehrt, die α2-Fraktion war nur noch mäßig vermehrt, wogegen die γ-Fraktion eine zunehmende Tendenz zeigte. Nach 6 Wochen waren die Elektropherogramme normal bis auf eine Vermehrung der γ-Fraktion. Die Blutsenkungsgeschwindigkeit war am Unfalltag nicht beschleunight. Am 6. Tag betrug die Beschleunigung im Durchschnitt 20–40 mm, nach 3 Wochen bemerkte man einen geringen Beschleunigungsrückgang, und nach 6 Wochen war die Senkungsreaktion wieder normal. Das Weltmannsche Hitzekoagulationsband war am 1. Tag normal, am 6. Tag bestand eine Verkürzung des Bandes auf Röhrchen 4, nach 3 Wochen eine geringe Verbreiterung, und nach 6 Wochen war die Reaktion normal. Die Flockungsreaktion nachTakata war immer negativ. Die Schwere und das Ausmaß einer Fraktur zeigten sich in intensiveren Reaktionen. Eine Beziehung zwischen Sitz der Fraktur und den Reaktionsabläufen bestand nicht. Nach den Wuhrmannschen Konstellationstypen lassen sich die Frakturen vom physiko-chemischen Standpunkt aus in den Typus der akuten und der subakut-chronischen Entzündung einteilen. Vom Unfalltag an bis etwa 3 Wochen nachher zeigt sich im Bluteiweißbild der akute Entzündungstyp. Von der 3.–6. Woche entsprechen die Bluteiweißverhältnisse dem Typus der subakut-chronischen Entzündung. Mit diesem charakteristischen Verhalten der Serumproteine wäre auch der physiko-chemische Beweis für die Entzündungsnatur der Knochenheilung erbracht. Zwischen der Normalisierung der Reaktionen und der Knochenheilung bestanden wichtige Zusammenhänge. Bei 2 Patienten mit verzögerter Callusbildung normalisierten sich die Proteinverhältnisse erst nach 3 Monaten. Infolgedessen glauben wir, aus dem Elektropherogramm und den Serumlabilitätsproben prognostische Schlüsse auf den Ausgang einer Frakturheilung ziehen zu dürfen. Für die Therapie der Knochenbruchheilung empfiehlt es sich. die Dysproteinämie durch Eiweißzufuhr zu substituieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01440740
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  • 16
    Electronic Resource
    Electronic Resource
    Inactivity of terbinafine in a rat model of pulmonary aspergillosis (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 832-835 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a model of bronchopulmonary aspergillosis terbinafine did not improve survival of experimental animals in doses up to 80 mg/kg/day despite adequate lung concentrations. Pretreatment and aerosolization of the compound were also ineffective. Terbinafine was markedly less active in vitro when serum was used instead of Yeast-Nitrogen-Glucose-broth. It is concluded that a lack of bioavailability in the presence of serum may explain the lack of activity of terbinafine in experimental aspergillosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967386
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  • 17
    Electronic Resource
    Electronic Resource
    Die Aktivität Atp-dephosphorylierender Fermente im menschlichen Blut (1957)
    Springer
    Journal of molecular medicine 35 (1957), S. 661-663 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei den Erythrocyten finden sich 5–30% der ATP-spaltenden Fermentaktivität an der Oberfläche der unzerstörten Zelle. Nach Hämolyse werden in den bei 20 000 g abzentrifugierten und gewaschenen korpuskulären Bestandteilen 10 bis 30% gefunden. Unter den gegebenen Bedingungen nicht sedimentierbar sind 70–90%. Die Existenz eines Fermentes an den Erythrocytenoberflächen, das energiereiches Phosphat abbaut, läßt den Schluß zu, daß an den Erythrocytenoberflächen energieverbrauchende Prozesse stattfinden, die wohl zum Teil zum aktiven Stoffaustausch an den Membranen verwandt werden, gleichzeitig aber auch den Durchtritt dephosphorylierter Adeninderivate ermöglichen. Im Plasma findet sich eine ATP-Dephosphorylierung, die bei Hepatitiskranken verstärkt ist und nicht gleichsinnig mit der nachRaabe bestimmten alkalischen Phosphatase verläuft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01481264
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  • 18
    Electronic Resource
    Electronic Resource
    Calcium carbonate as a phosphate binder in dialysis patients: Evaluation of an enteric-coated preparation and effect of additional aluminium hydroxide on hyperaluminaemia (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 59-67 
    Details
    ISSN: 1432-1440
    Keywords: Calcium carbonate ; Phosphate ; Chronic renal failure ; Aluminium ; Hyperparathyroidism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Calcium carbonate has been successfully used as a phosphate binder in patients with chronic renal failure; however, a high frequency of hypercalcaemia has been reported. To study the effects of calcium carbonate preparations with different dissolution characteristics on the incidence of this side effect, we conducted a double-blind, crossover trial in 21 patients undergoing chronic haemodialysis. Aluminium hydroxide therapy was replaced with calcium carbonate. The subjects then randomly received either an enteric-coated or a gastric-coated preparation. Calcium carbonate (3.1–3.6 g/d) controlled serum phosphate concentrations as effectively as aluminium hydroxide (2.9 g/d). Concurrently, there was a significant rise in mean serum calcium and a fall in serum concentrations of both parathyroid hormone and osteocalcin, the latter suggesting a decrease in bone turnover. Overall, hypercalcaemic episodes developed in 9 patients (43%) and occurred at a considerable frequency (33 episodes per 100 patient-months) during treatment with the gastric-coated formulation. Following conversion to enteric-coated calcium carbonate (3.6 g/d) patients had fewer occurrences of hypercalcaemia (12 episodes per 100 patient-months,P〈0.05) and, as compared to the gastric-coated preparation, increases in serum calcium 〉3.00 mmol/l were not observed at all. Hyperaluminaemia was regressive during therapy with calcium carbonate, but addition of small doses of aluminium hydroxide caused a large rise in serum aluminium concentrations after infusion of desferrioxamine, indicating an enhanced rate of absorption or aberrant compartmentalization of aluminium. We conclude that calcium carbonate can control hyperphosphataemia in dialysis patients. However, undesirable hypercalcaemic episodes may occur, the frequency and severity of which can be lowered by the use of an enteric-coated preparation. Concomitant use of aluminium hydroxide and calcium carbonate should be restricted to patients in whom the degree of aluminium accumulation is monitored by serial desferrioxamine tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01666818
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  • 19
    Electronic Resource
    Electronic Resource
    The optical gap of NiO (1992)
    Springer
    The European physical journal 86 (1992), S. 207-215 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The nature of the optical absorption gap in NiO at 4.0 eV is investigated. It is found that this gap is due to a band to band transition, where an electron is taken out of the valence band and placed into the conduction band. The optical gap of 6.0 eV found in Ni∶MgO is of a nature, where an electron is taken out of the oxygen 2p band and placed into the first affinity level of the Ni2+ ion (3d 8L»3d 9L−1). The impurity band created in Ni1−x Li x O by the Li ions is found 2.3 eV below the bottom of the conduction band in agreement with model predictions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01313827
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  • 20
    Electronic Resource
    Electronic Resource
    Acceptors in Li doped NiO (1992)
    Springer
    The European physical journal 88 (1992), S. 247-248 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The electronic structure of the Li doped large gap semiconductor (insulator) NiO is investigated by photoemission and inverse photoemission spectroscopy. Spectral weight is produced by the Li doping within the gap at 1.4 eV above the top of the valence band. It is interpreted as due to an acceptor level associated with a LiO complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01323579
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