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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 25 (1983), S. 475-480 
    ISSN: 1432-1041
    Keywords: hypotensive effect ; diltiazem ; plasma level ; normotension ; essential hypertension ; plasma renin ; arterial vasodilatation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The hypotensive effect of acute and long-term, intravenous and oral administration of the calcium antagonist, diltiazem, was investigated in 8 normotensive volunteers and 55 patients with essential hypertension. Diltiazem i.v. infusion of 45 mg/h (0.5 mg/min, then 1.0 mg/min, each for 30 min rapidly decreased both blood pressure (BP) from 164±22/98±8 to 144±15/86±9 mmHg (mean±SD) and total peripheral resistance from 32.6±8.4 to 25.3±5.4 mmHg/l/min (p〈0.001), and increased stroke volume from 58.2±9.5 to 64.2±8.6 ml/beat (p〈0.05). It altered neither heart rate nor cardiac output in the hypertensives (n=10). Oral diltiazem 60 mg rapidly decreased BP from 155±10/103±6 to 142±12/90±8 mmHg after 3 hours (p〈0.01/p〈0.001) in hypertensives (n=8), but not in normotensives (n=8). Diltiazem 90 mg p.o. decreased BP from 157±15/102±9 to 129±13/83±8 mmHg (p〈0.01) in hypertensives (n=15), and reduced the heart rate from 71±8 to 65±8 beats/min (p〈0.01). The drug did not change plasma renin activity either in normotensives or hypertensives. The fall in diastolic BP was correlated with the plasma diltiazem concentration (r=0.910, n=6, p〈0.05). Long-term treatment with diltiazem 30mg t.d.s. decreased BP from 163±12/104±8 to 145±9/88±9 mmHg (p〈0.001, n=13), and 60mg t.d.s. decreased BP from 169±15/102±6 to 148±13/87±8 mmHg (p〈0.001, n=8), and significantly reduced the heart rate (p〈0.01) in hypertensives. Thus, the hypotensive action of diltiazem, which is due to arterial dilatation, is effective, either on intravenous or oral administration, during acute and long-term treatment of essential hypertension.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Il nuovo cimento della Società Italiana di Fisica 10 (1988), S. 145-159 
    ISSN: 0392-6737
    Keywords: Kinetic and transport theory ; Statistical mechanics ; Function theory, analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Sulla base di appropriate ipotesi fisiche, concernenti le frequenze di collisione, le distribuzioni di probabilità di «scattering» e le condizioni iniziali, si perviene a costruire un sistema diN equazioni di conservazione a partire dal sistema di Boltzmann, tramite il quale resta formulato un problema non lineare di evoluzione per gliN gas di una miscela assegnata. Vengono discusse le restrizioni sia fisiche che matematiche connesse con la soluzione del sistema trovato per i due casi di sola rimozione, e, rispettivamente, di rimozione e «scattering», occorrente fra le differenti specie di particelle costituenti la miscela di gas considerata.
    Abstract: Резюме На основе соответствующих гипотез относительно частот соударений, распределений вероятности рассеяния и начальных условий выводится системаN уравнений сохранения, исходя из системы Больцмана, определяющей нелинейную проблему эволюции дляN газов заданной смеси. Затем обсуждаются физические и математические ограничения, связанные с решением для рассматриваемой системы, для двух случаев: только удаление и удаление и рассеяние различных типов частиц, которые входят в рассматриваемую смесь.
    Notes: Summary On the basis of appropriate hypotheses, concerning the collision frequencies, the scattering probability distributions and the initial conditions, a system ofN conservation equations is derived starting from the Boltzmann system governing a nonlinear evolution problem for theN gases of an assigned mixture. The physical and mathematical constraints connected with the solution of the system so obtained are then discussed for the two cases of only removal and, respectively, of both removal and scattering between the different species of particles, which the mixture considered consists of.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Il nuovo cimento della Società Italiana di Fisica 10 (1988), S. 1013-1029 
    ISSN: 0392-6737
    Keywords: Kinetic and transport theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Nel presente lavoro si illustra un sistema di equazioni iperboliche non lineari di conservazione, che si incontra nello studio di un problema di evoluzione per una miscela di gas di particelle interagenti in presenza di soli effetti di rimozione. Soluzioni analitiche esplicite di tale sistema sono costruite e commentate su base sia matematica che fisica.
    Abstract: Резюме Рассматривается система нелинейных гиперболических уравнений сошранения, возникающих при исследовании проблемы эволюции смеси газов взаимодействующих частиц в присутствии зффектов удаления. Получаются точные аналитические решения для такой системы. Проводится обсуждение полученных результатов с математической и физической точек зрения
    Notes: Summary A system of nonlinear hyperbolic conservation equations, arising in the study of an evolution problem of a mixture of gases of interacting particles in the presence of only removal effects, is illustrated. Explicit analytical solutions to such system are obtained and commented on both mathematical and physical grounds.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 2814-2817 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: At room temperature, cyanoacetylene undergoes a liquid–solid transition at 70±30 MPa and further a polymerization reaction at 1.5 GPa. Raman spectra indicates that the crystal structure of the high-pressure phase is isomorphic with the monoclinic low-temperature structure (P21/m, Z=2), in which linear cyanoacetylene molecules are joined with CH NC hydrogen bonds to form infinite one-dimensional chains. The internal stretching frequency of the C–H proton donor decreases wtih increasing pressure, while that of the C 3/4 N proton acceptor increases. The librational modes associated with the rotational motions of the rigid molecules show large shifts to higher frequencies with pressure. The observed frequency shifts are attributed to the strengthening of the CH⋅⋅⋅NC hydrogen bond in the one-dimensional molecular chain.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 4565-4568 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Raman spectra were measured for liquid (0–0.7 GPa), crystalline cubic (0.7–0.9 GPa), and orthorhombic (0.9–3.5 GPa) phases in C2H2 at room temperature. For the orthorhombic phase, the high-pressure behavior of the librational and internal vibrations was obtained in a wide pressure range. The frequencies of all the librational modes increased monotonically with pressure, while those of the internal modes showed a variety of frequency shifts depending on vibrational mode. These high-pressure data will be of great use for the construction of theoretical models for the intermolecular interactions in crystalline C2H2.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 778-782 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Cyanoacetylene underwent polymerization reaction in a solid phase at pressures above 1.5 GPa. The Raman study of the reaction product showed that the polymer had a conjugated linear backbone with CN pendant groups. The Raman spectra for this substituted polyacetylene demonstrated a resonance behavior similar to that reported for trans-polyacetylene. The optical gap associated with the π–π* transition in the conjugated system was smaller than that of trans-polyacetylene, probably due to the resonance interactions between the CN triple bonds and the conjugated double bonds.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 89 (1988), S. 529-534 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The mechanism and kinetics of the pressure-induced polymerization of acetylene were studied by Raman spectroscopy. The polymerization reaction occurred in the orthorhombic phase at room temperature and pressures above 3.5 GPa. Dominant formation of trans-polyacetylene suggested that the monomer underwent trans opening of the triple bond and polymerized along the diagonal of the bc plane of the unit cell. The reaction was described as an idealized one-step and one-dimensional growth process by an Avrami equation with an exponent 1.34.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Cell Differentiation and Development 27 (1989), S. 46 
    ISSN: 0922-3371
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 106 (1964), S. 317-325 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 0921-8777
    Keywords: Age dependence, fish ; DNA repair ; O^6-Methylguanine-DNA methyltransferase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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