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  • 11
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Inst. and Methods in Physics Research, B 10-11 (1985), S. 1038-1041 
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters 20 (1966), S. 124-125 
    ISSN: 0031-9163
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 39 (1994), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Normal immune homeostasis is regulated partly by a small population of CD4+ T cells that react to autologous major histocompatibility complex class-II molecules on self-cells. Decreased autoreactive T-cell responses are associated with cancer. Tumour growth causes syngeneic macrophages (Mø) to suppress autoreactive T-cell proliferation by decreasing Mø class-II expression and increasing Mø production of the suppressor molecule prostaglandin E2 (PGE2). Because interferon-γ (IFN-γ) is a potent Mø activation molecule which regulates both Mø PGE2 and class-II expression, the effects of IFN-γ on tumour-induced suppression of autoreactive T-cell proliferation were investigated. Exogenous IFN-γ increased normal host (NH) CD4+ autoreactive T-cell proliferation stimulated by syngeneic NHMø but decreased proliferation stimulated by tumour-bearing host (TBH) Mø. Antibody (Ab) neutralization of endogenous IFN-γ activity reduced TBH Mø-mediated suppression. Kinetic studies showed that endogenous IFN-γ suppressor activity was not exclusive during T-cell activation. Indomelhacin treatment blocked IFN-γ-induced suppression in TBH Mø-T cell cultures. TBH Mø-T cell cultures contained significantly more PGE2 than those containing NH Mø. Exogenous IFN-γ increased early PGE2 production in TBH Mø cultures but decreased production in NHMø cultures. The Ab-mediated neutralization of endogenous transforming growth factor-β or tumour necrosis factor-x reduced TBH Mμ-mediated suppression and blocked IFN-γ-induced suppression. Short-term treatment of Mμ with IFN-γ before their addition to T cells caused TBH Mμ to stimulate T-cell proliferation, which suggests that early suppressor molecule production by TBHMø inhibits synthesis or activity of IFN-γ-induced stimulatory monokines. These results show that tumour growth causes Mø to suppress autoreactive T-cell responses by allowing IFN-γ to induce Mø suppressor molecules, which block production or activity of stimulatory monokines.
    Type of Medium: Electronic Resource
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  • 14
    facet.materialart.
    Unknown
    Leiden, etc. : Periodicals Archive Online (PAO)
    Mnemosyne. n.s.:16 (1888) 82-90 
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  • 15
    facet.materialart.
    Unknown
    Leiden, etc. : Periodicals Archive Online (PAO)
    Mnemosyne. n.s.:43 (1915) 49-72 
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  • 16
    facet.materialart.
    Unknown
    Leiden, etc. : Periodicals Archive Online (PAO)
    Mnemosyne. n.s.:44 (1916) 181-202 
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Journal of nondestructive evaluation 6 (1987), S. 135-146 
    ISSN: 1573-4862
    Keywords: Ultrasonics ; fiber optics ; lasers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An innovative approach to nondestructive evaluation (NDE) using noncontacting optical sensors has demonstrated. In this effort a single mode optical fiber interferometer (OFI) was used to sense the presence and form of Rayleigh waves traveling along the surface of a steel test bar at a velocity of nearly 3mm/µs. Acousto-optic time-domain data was successfully used to detect the presence and locate the position of a test “flaw” (a machined slot) in the bar, and spectrum analysis was used to estimate its geometry and size. This approach has many potential applications in the ultrasonic evaluation of real flaws in structures with complex geometries. Coupled with the authors' earlier work demonstrating the feasibility of generating acoustic waves in metals using laser light pulses transmitted through the fiber optic probes, this latest achievement points to the development of a fully noncontacting, fiber optic based thermal-acousto-photonic (TAP) NDE system, with potential applications to the reliability testing of many important structures where composition, scale, geometry, or restricted access preclude the use of conventional NDE techniques.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Journal of nondestructive evaluation 6 (1987), S. 57-64 
    ISSN: 1573-4862
    Keywords: Ultrasonics ; fiber optics ; lasers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract This paper describes experiments designed to generate acoustic waves by using a laser pulse, transmitted through fiber optics, to thermally shock the surface of a steel specimen. The purpose of this effort was to explore the noncontacting generation of Rayleigh surface waves appropriate to the interrogation of structures for the detection of subcritical defects, with the ultimate goal of developing an efficient laser-based nondestructive evaluation technique utilizing flexible fiber optics.
    Type of Medium: Electronic Resource
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  • 19
    ISSN: 1433-0385
    Keywords: Key words: Primary and secundary form of Baker's cyst ; Extirpation. ; Schlüsselwörter: Primäre und sekundäre Baker-Cyste ; Exstirpation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. In der Unfallchirurgischen Universitätsklinik Köln wurden von 1988 bis 1997 19 Patienten an einer Baker-Cyste operiert. Die subjektiven und objektiven Ergebnisse wurden mit Hilfe eines Fragebogens sowie einer klinischen und sonographischen Nachuntersuchung erfaßt (Rücklauf: 95 %). Der präoperative Status wurde durch klinische Untersuchung, Sonographie und Anfertigung von Röntgenaufnahmen des Kniegelenks ermittelt. Wir differenzierten zwischen der angeborenen primären Cyste (39 %) und der sekundären Form, die immer mit einer Kniebinnenpathologie assoziiert ist (61 %). Bei allen sekundären Cysten wurde eine Arthroskopie durchgeführt. Als postoperative Komplikationen traten in einem Fall ein revisionspflichtiges Hämatom und in einem anderen Fall ein punktionspflichtiger Erguß auf. Das Operationsergebnis wurde von 61 % der Patienten mit „sehr gut“ und von 39 % mit „gut“ bewertet. Alle nachuntersuchten Kniegelenke waren passiv und aktiv frei beweglich. In einem Fall kam es zu einem Rezidiv. Nach unserer klinischen Erfahrung sollten primäre Baker-Cysten immer entfernt werden. Bei der sekundären Cyste muß neben der Exstirpation die Bedeutung der arthroskopischen Diagnostik und Therapie sowie der Sanierung der Grundkrankheit diskutiert werden.
    Notes: Summary. Baker's cysts were treated operatively in 19 patients in the Department of Traumatology of the University of Cologne from 1988 to 1997. The subjective and objective results were evaluated with a questionnaire and a clinical examination and sonography (follow-up: 95 %). All patients were examinated before surgery, sonography and X-ray of the knee were performed. We differentiated between the congenital primary cyst (39 %), and the secondary form, which was always associated with an intraarticular lesion (61 %). Arthroscopy was performed in all secondary forms of Baker's cyst. Postoperative complications were two reinterventions due to one hematoma and one effusion. Patient's evaluation of operation result was “excellent” in 61 % and “good” in 39 % of cases. All knee joints had a full range of motion. There was only one case of a recurrent cyst. The primary form of Baker's cyst has always to be extirpated, according to our clinical experience. The extirpation of the secondary Baker's cyst and the relevance of arthroscopy and treatment of the basic disease have to be discussed.
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 1619-7089
    Keywords: Manganese ; Positron emission tomography ; Tracer kinetic modeling ; Myocardial perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is a need for a quantitative myocardial perfusion agent that does not require an on-site cyclotron. Early studies with manganese demonstrated that this trace metal is of potential use for myocardial imaging.52mMn can be produced in a52Fe-52mMn generator and is suitable for positron emission tomographic (PET) imaging. The purpose of this study was to evaluate52mMn with regard to its potential to quantitatively assess myocardial perfusion. Dynamic PET imaging was performed in six pigs with various doses of dipyridamole to increase blood flow. Retention (R) and model-basedK 1 values were correlated with microsphere blood flow. The models consisted of one (K 1,k 2) and two (K 1,k 2,k 3) tissue compartments. Anterior, lateral and septal regions showed a good myocardium-to-background ratio; the evaluation of the inferior wall was impaired by high liver uptake. Linear regression yielded the following equations:K 1=1.152 flow+0.059 (r=0.92),R=0.069 flow+0.034 (r=0.84). Based on these regressions,K 1 increased 2.7-fold andR 2.6-fold in the examined flow range of 0.5–2 ml/min/g (fourfold increase), demonstrating an underestimation of higher flow rates by both measures. It is concluded that52mMn allows the qualitative assessment of myocardial perfusion but does not meet the requirements of a quantitative myocardial perfusion agent.
    Type of Medium: Electronic Resource
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