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  • 11
    Electronic Resource
    Electronic Resource
    Zwei Fälle von Geschwulstbildung im Augenhintergrunde (1866)
    Springer
    Virchows Archiv 36 (1866), S. 448-454 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02042755
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  • 12
    Electronic Resource
    Electronic Resource
    Melphalan-resistant multiple myeloma: results of treatment according to the M-2 protocol (1985)
    Springer
    Cancer chemotherapy and pharmacology 14 (1985), S. 279-281 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A group of 46 patients with melphalan-resistant multiple myeloma was treated according to the M-2 protocol with melphalan, prednisolone, BCNU, cyclophosphamide, and vincristine. According to the Salmon and Durie classification, four patients had stage II A; 36, stage III A; and six, stage III B disease. Treatment resulted in five patients (11%) entering remission, while 21 (46%) had stable and 20 (43%) had progressive disease. The median survival for all patients was 12.5 months, patients in remission surviving longer (median 46 months) than those with stable disease (median 15.4 months) or progressive disease (median 6.9 months). Compared with other treatment regimens used in melphalan-resistant myeloma, the remission rate is low but the median survival exceeds that reported by most other authors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258135
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  • 13
    Electronic Resource
    Electronic Resource
    Ueber Fettembolie (1866)
    Springer
    Virchows Archiv 35 (1866), S. 321-358 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01879327
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  • 14
    Electronic Resource
    Electronic Resource
    Modulation of in vitro myelopoiesis by alloreactive T cell clones (1986)
    Springer
    Annals of hematology 52 (1986), S. 305-315 
    Details
    ISSN: 1432-0584
    Keywords: T Cell Clones ; Myelopoiesis ; CFU-GM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Regulatory effects of mixed lymphocyte culture (MLC)-derived CD4+ human T cell clones on granulocyte-macrophage colony (CFU-GM) formation by normal bone marrow (BM) were studied in an initial attempt to establish an in vitro model for the negative feedback control of myelopoiesis by alloactivated T cells. This is likely to be of clinical significance in the aberrant control of haematopoiesis during some cases of graft-versus-host disease (GVHD) after allogeneic BM transplantation. Whilst 5 such alloproliferative clones generally failed to suppress CFU-GM, the majority of clones with natural killer (NK)-like activity [10], or those with suppressive activity in MLC [2], regularly and strongly suppressed in this system, reinforcing the view that certain T cells may have potent negative regulatory effects on haematopoiesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320794
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  • 15
    Electronic Resource
    Electronic Resource
    Response-oriented therapy with CHOP and VIM-Bleo in high-grade malignant non-Hodgkin's lymphomas (1988)
    Springer
    Annals of hematology 56 (1988), S. 269-271 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin's lymphomas ; Chemotherapy ; Consolidation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty four patients with high grade malignant NHL (stage II 8, stage III 4, stage IV 12 patients respectively) were treated with a response-oriented regimen: Treatment was initiated according to the CHOP-protocol. Patients achieving at least a partial remission after 2 and a complete remission (CR) after 4 cycles were continued on CHOP to a total of 9 cycles. Patients not meeting these criteria were switched to a combination of Etoposide, Ifosfamide, Methotrexate, and Bleomycin (VIM-Bleo). With CHOP treatment, 16 patients (67%) achieved a CR. Of the remaining 8, 7 were treated with VIM-Bleo; 5 of these entered CR for a overall CR rate of 21/24 (88%). With a median follow up of 28 months 7 patients relapsed: 6 relapses occurred in patients with a rapid initial response and treated only with CHOP. We conclude, that there is a significant risk of relapse even in patients readily responding to CHOP and that consolidation therapy with a non cross-resistant regimen may improve results in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320288
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  • 16
    Electronic Resource
    Electronic Resource
    Neue Möglichkeiten der Strukturanalyse von Knochenbiopsien bei Anwendung der Mikrocomputertomographie (μCT) (1995)
    Springer
    Der Pathologe 16 (1995), S. 342-347 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Knochen ; Beckenkammbiopsie ; Spongiosastruktur ; Morphometrie ; Key words Iliac crest bone biopsy ; Microcomputed tomography ; Cancellous bone ; Histomorphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The combined histological and microcomputed analysis of human iliac crest biopsies leads to major advances in our understanding of three-dimensional bone architecture. Microcomputed tomography avoids the time-consuming reconstruction and artifacts of serial sections. Furthermore, its high resolution allows the recording of structural differences as low as 10 mm. Thus, three-dimensional analysis in combination with histological evaluation of cellular dynamics facilitates earlier and easier recording of changes of cancellous bone.
    Notes: Zusammenfassung Es wird die kombinierte Anwendung und quantitative Auswertung 2dimensionaler histologischer Schnitte sowie 2- und 3dimensionaler Mikrotomogramme zur Analyse der Knochenstruktur in Knochenbiopsien beschrieben. Gegenüber dem sehr zeitaufwendigen Verfahren der 3dimensionalen Rekonstruktion aus histologischen Schnitten ist die Mikrotomographie (μCT) schnell genug, um für Routineuntersuchungen in Frage zu kommen. Überdies arbeitet die μCT zerstörungsfrei und vermeidet Schnittartefakte. Art und Ausmaß krankheitsbedingter Spongiosaveränderungen können anhand der 3 D-Tomogramme, dank ihrer hohen Ortsauflösung von rund 10 μm, sehr exakt dargestellt werden. Besonders in Knochenbiopsien mit einer Reduktion der Spongiosastruktur wird das Ausmaß der Strukturveränderungen 3dimensional wesentlich deutlicher als im 2dimensionalen Schnittpräparat. Das Verfahren stellt ein wichtiges Bindeglied zwischen nichtinvasiv erhobenen Strukturdaten und histologischen Veränderungen dar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050112
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  • 17
    Electronic Resource
    Electronic Resource
    Über nichtlineare Resonanzen im elektrischen Massenfilter als Folge von Feldfehlern (1961)
    Springer
    The European physical journal 164 (1961), S. 588-594 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Abweichungen vom idealen raumzeitlichen Verlauf des Vierpolfeldes im elektrischen Massenfilter rufen bei bestimmten Werten der Feldparameter nichtlineare Resonanzen der Ionenbewegung hervor, die analog den Stoppbändern bei Kreisbeschleunigern mit alternierendem Feldgradienten entstehen. Genügend starke Störungen führen zu einer Abnahme der Intensität des stabilisierten Ionenstrahls. Verschiedene Feldfehler werden im Hinblick auf die theoretisch möglichen Resonanzen diskutiert und die Ergebnisse mit experimentellen Beobachtungen verglichen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01378433
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  • 18
    Electronic Resource
    Electronic Resource
    Isotopentrennung mit dem elektrischen Massenfilter (1961)
    Springer
    The European physical journal 164 (1961), S. 581-587 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Es wird über Versuche zur Trennung wägbarer Mengen von Magnesium berichtet. Bei Anreicherung eines der beiden selteneren Isotope (natürliche Häufigkeiten: Mg24-79%, Mg25-10%, Mg26-11%) konnten in etwa zehnstündigem Trenngang bis zu einigen hundert Mikrogramm des jeweils aufgefangenen Isotops gesammelt werden. Mg26 wurde auf 84%, Mg25 in einem anderen Experiment auf 69% angereichert. Verschiedene Fehlerquellen und Wege zur Verbesserung der Apparatur werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01378432
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  • 19
    Electronic Resource
    Electronic Resource
    127. Fehler und Gefahren der Probeexcision im Halsbereich (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 653-655 
    Details
    ISSN: 1435-2451
    Keywords: Cervical biopsy ; Neurological complications ; Suitable anaesthesia ; Probeexcision im Halsbereich ; Neurologische Komplikationen ; Geeignete Anaesthesie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 433 Patienten mit Probeexcision im Bereich des Halses fanden sich neben Lymphadenitiden in erster Linie hämatologische Malignome und Metastasen maligner Tumoren. In 4,8 % traten behandlungsbedürftige Komplikationen auf, zum einen Wundheilungsstörungen (Hämatome, Entzündungen), zum zweiten neurologische Komplikationen des Nervus accessorius. Bei 4 Patienten bildeten sich diese vollständig zurück, einmal blieb eine Parese des Musculus deltoideus bestehen. Die Analyse des Krankengutes läßt erkennen, daß vor allem ungeeignete Narkoseverfahren (Lokalanaesthesie) bei in der Tiefe gelegenen, schlecht abgrenzbaren Tumoren zu Komplikationen geführt hatten.
    Notes: Summary In 433 cervical biopsies lymphadenitis, metastases of malignant tumors and of the haematologic system could be found first of all. In 4.8 % complications needed a further treatment, firstly trouble in wound healing (haematoma, inflammation), secondly neurological complications of the accessorial nerve. These complications receded in 4 patients completely, in one patient a paralysis of the deltoid muscle continued. The analysis of our patients suggested that unsuitable anaesthesia (local anaesthesia) for deeper-seated, badly demarked tumors is responsible for most of the complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01275952
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  • 20
    Electronic Resource
    Electronic Resource
    Pairing effects in quasi-elastic neutron transfer between Tin isotopes (1983)
    Springer
    The European physical journal 313 (1983), S. 189-195 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The transfer of neutrons between low-lying states of Tin isotopes has been measured in the reaction120Sn→112Sn at energies below the Coulomb barrier. The transfer probabilities are deduced as function of the classical minimum distance from transfer and scattering cross sections at different angles and two energies. At the smallest distances very large transfer probabilities,p t =0.5, are observed for one- and two-neutron transfer. The two-neutron transfer is significantly enhanced as compared to a successive independent single-nucleon transfer. The definition of enhancement is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01417226
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