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  • 11
    ISSN: 1432-2102
    Keywords: Schlüsselwörter LITT ; Laserablation ; MR-Thermometrie ; Key words Laser ; MR thermometry ; LITT ; Liver cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary MR-guided LITT (laser-induced thermotherapy) is currently being evaluated for its effectiveness in clinical oncology. MR-guided LITT is defined as a minimally invasive technology based on the effects of the applied Nd-YAG laser on tumorous tissue. Due to specific characteristics of the laser-induced coagulative effect, online monitoring via MR thermometry is possible and extremely precise. In a period of 6 years 335 patients suffering from malignant soft tissue tumors were prospectively treated via MR-guided LITT. We evaluated the local tumor control rate, the rate of complications and the survival data from the clinical and MRI follow-up. Our results prove that MR-guided LITT results in a extremely low rate of side effects and an effective tumor control rate higher than 95%, depending on the size of the lesion. It is concluded that this therapeutic concept is of clinical value for patients with primary and secondary liver cancer, malignant lymph node involvement, abdominal recurrent tumors and tumors of the head and neck.
    Notes: Zusammenfassung Die interventionelle MR-gesteuerte laserinduzierte Thermotherapie (LITT) wird derzeit klinisch und im Rahmen prospektiver Studien bei unterschiedlichen onkologischen Fragestellungen eingesetzt und evaluiert. Per definitionem stellt die MR-gesteuerte laserinduzierte Thermotherapie ein minimalinvasives Therapieverfahren dar, das auf der Laserwirkung mit resultierendem koagulativen Effekt beruht. Der thermoablative Effekt wird dabei „online”überwacht und dokumentiert durch den Einsatz spezieller MR-Sequenzprotokolle. Innerhalb eines Zeitraums von 6 Jahren wurden dabei prospektiv 335 Patienten mit malignen Weichteiltumoren therapiert und die Tumorortskontrollrate, die Komplikationsrate sowie die Überlebensdaten evaluiert. Die gewonnenen Ergebnisse zeigen, daß die MR-gesteuerte LITT ein nebenwirkungsarmes Therapieverfahren darstellt, mit einer enorm hohen Präzision und einer Tumorortskontrollrate bei optimierter Technik von 〉95%. Als Indikationen werden vorgestellt die Thermotherapie von primären und sekundären Lebermalignomen, sekundärer Lymphknoteninvasionen, abdomineller Rezidivtumoren sowie Tumorfragestellungen in der Kopf-/Halsregion.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Plant systematics and evolution 56 (1906), S. 337-340 
    ISSN: 1615-6110
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. In this study, four new markers located on bovine Chromosome 1 were tested for linkage with the polled condition in the Simmental and Pinzgauer breeds. The microsatellites INRA212 (D1S42) and the gene for keratin-associated protein 8 (KAP8) show significant linkage with polled at θ= 0.00 (Lod = 6.92), and θ= 0.033 (Lod = 6.52) respectively. The microsatellite INRA117 (D1S20) and the gene for interferon-α receptor (IFNAR) show maximum Lod scores of 2.1 and 1.8 at a recombination rate of zero.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 13 (1981), S. 1107-1123 
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1,1-Dichlorocyclopropane has been produced by addition of CH2(1A1) to 1,1-dichloroethylene. CH2(1A1) was generated by the photolysis of ketene at 277-334 nm. The 1,1-dichlorocyclopropane was formed in a chemically activated state, had an energy content between 386 and 400 kJ/mol, and reacted in two parallel channels to 2,3-dichloropropene and 1,1-dichloropropene. 1,1-Dichloropropene was also formed directly by insertion of CH2(1A1) into the CH bond of 1,1-dichloroethylene. As secondary reactions elimination of HCl from chemically activated 2,3-dichloropropene occurred with 3-chloropropyne and chloroallene as products. In some of the experiments perfluoropropane was added as an inert gas. The apparent rate constants for the isomerization and elimination reactions are reported. The results of RRKM calculations including distribution functions for the activated 1,1-dichlorocyclopropane and a step-ladder model for the deactivation verify the proposed reaction scheme.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 16 (1984), S. 835-847 
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chlorocyclopropane has been produced by addition of CH2(1A1) and CH2(3B1) to chloroethene. CH2 was generated by the photolysis of ketene at 313 and 366 nm. Chlorocyclopropane was formed in a chemically activated state, had an energy content between 378 and 427 kJ/mol, and reacted in three parallel channels to 3-chloropropene, cis- and trans-1-chloropropene. As secondary reactions elimination of HCl from the chemically activated primary products occurred to form allene and propyne. The apparent rate constants for the isomerization and elimination reactions are reported. The results of RRKM calculations including distribution functions for the activated chlorocyclopropane and a stepladder model for the deactivation support the proposed reaction scheme.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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