Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 11
    Digitale Medien
    Digitale Medien
    Significance of antibodies to cardiolipin in unselected patients with systemic lupus erythematosus: clinical and laboratory associations (1995)
    Springer
    Rheumatology international 15 (1995), S. 23-29 
    Details
    ISSN: 1437-160X
    Schlagwort(e): Anti-cardiolipin antibodies ; IgG ; IgM Systemic lupus erythematosus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In a multicentre study anticardiolipin antibodies of the IgG and IgM isotypes were measured by a solid phase enzyme immunoassay in 368 patients with systemic lupus erythematosus (SLE) who were not selected on the basis of features of antiphospholipid syndrome. Clinical and laboratory associations of increased levels of anticardiolipin antibodies were evaluated. IgG and IgM antibodies to cardiolipin were documented in 224 (60.9%) and 128 (34.8%) patients, respectively. Regarding the symptoms of antiphospholipid syndrome, elevated amounts of anticardiolipin IgG were significantly associated with spontaneous abortion (P〈0.001), thrombocytopenia (P〈0.01), livedo reticularis (P〈0.01) and a positive direct Coombs test (P〈0.05), but not with thrombosis or central nervous system diseases such as epilepsy and psychosis. IgM antibodies to cardiolipin were associated with a positive direct Coombs test (P〈0.01), but with no other symptom of antiphospholipid syndrome. The predictive values of anticardiolipin antibody determinations in unselected SLE patients were poor for all features of antiphospholipid syndrome because of high proportions of false-positive and false-negative results. As for other manifestations of SLE, positive correlations between raised antibodies to double-stranded DNA and the occurrence of anticardiolipin antibodies of the IgG isotype were observed, and anticardiolipin IgM was negatively associated with nephritis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00286765
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 12
    Digitale Medien
    Digitale Medien
    Circulating immune complexes in HIV-infected persons (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 299-305 
    Details
    ISSN: 1432-1440
    Schlagwort(e): AIDS ; Immune complexes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Circulating immune complexes are part of normal immune defense mechanisms and, therefore, present in various infectious — bacterial and viral — diseases. On the other hand, they are obviously involved in pathogenic mechanisms, e.g., autoimmune diseases or different forms of malignancies. Both autoimmune and infectious features are recorded in the acquired immunodeficiency syndrome. Thus, elevated levels of antigen-antibody complexes in HIV-infected persons had to be expected, and they were in fact demonstrated by several authors. In a cohort study, it was additionally shown that circulating immune complexes are of prognostic relevance. After an introduction concerning the physiological and pathophysiological role of circulating immune complexes in general, their involvement in the course of HIV infections is presented and discussed. In addition, there is a critical review of the most commonly applied assay systems for the detection and quantification of circulating immune complexes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01649020
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 13
    Digitale Medien
    Digitale Medien
    Immunkomplexe bei Allergien: Nachweis von IgE-haltigen Immunkomplexen bei der Vaskulitis Churg-Strauss (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 563-569 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Allergy ; Vasculitis ; IgE-immune complexes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In five patients with vasculitis, hypereosinophilia and elevated serum-IgE levels, the diagnosis of Churg-Strauss syndrome was established. To identify a possible role of IgE in pathogenic mechanisms leading to vasculitis, a sequential precipitation of patients' sera was performed using various concentrations of polyethylene glycol 6000 (PEG). Using a radioimmunosorbent test, the precipitates obtained were tested for their IgE contents. Considerable amounts of IgE were found in the serum precipitates of all patients. In parallel studies, no IgE-containing precipitates were detected in sera from patients with different allergic diseases and high IgE serum levels. The demonstration of IgE-containing PEG precipitable material in all patients suffering from Churg-Strauss syndrome, together with the finding of an elevated C3d and C4 level and a decreased C3 level in one patient and an increased C3d level in a second patient, suggests that IgE-containing immune complexes play a pathogenic role in the Churg-Strauss syndrome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01735320
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 14
    Digitale Medien
    Digitale Medien
    Circulating immune complexes in malignant diseases increased detection rate by simultaneous use of three assay methods (1983)
    Springer
    Cancer immunology immunotherapy 15 (1983), S. 138-143 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary By using three different assay methods, circulating immune complexes have been detected in 85% of sera from patients with malignant melanoma, and in 77% of sera from patients with breast cancer. These methods were a C1q-binding assay, a double-antibody conglutinin-binding ELISA, and a polyethylene glycol 6000 precipitation technique followed by quantitative determination of immunoglobulins in the redissolved precipitate. Detection rates of circulating immune complexes using any one of these methods separately ranged from 33% to 56%, indicating the presence of different types of circulating immune complexes in cancer patients' sera. The combined use of the three methods mentioned resulted in an increased diagnostic sensitivity and a doubling of the predictive value. However, tests for circulating immune complexes cannot be considered as useful parameters for early diagnosis of cancer, since the comparatively low incidence of malignancies in the population at large, together with the presence of circulating immune complexes in other, nonmalignant, diseases of considerable prevalence, appears to preclude effective application of any nonspecific method for early diagnosis of cancer in general.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00199705
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...