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  • 11
    Electronic Resource
    Electronic Resource
    Book reviews (1982)
    Springer
    Annals of hematology 45 (1982), S. 359-361 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319531
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  • 12
    Electronic Resource
    Electronic Resource
    Treatment results of nine patients with burkitt's lymphoma (1986)
    Springer
    Annals of hematology 53 (1986), S. 279-286 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkins Lymphoma ; Burkitt's Lymphoma ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From 6/79 until 2/86, 9 patients (median age 39) with Burkitt's lymphoma were treated. Stage D disease was seen in 7 cases, stage C in two and stage A in one. The main symptom was abdominal pain or a rapidly progressing abdominal tumor. Three patients had bone marrow involvement and two had a Burkitt's leukemia. Three had typical chromosomal aberrations. Therapy consisted of a variety of chemotherapy regimens plus additional radiotherapy and/or bulk surgery. Two patients achieved complete remissions (of 6 and 20+ months duration), and 4 partial remissions were obtained. The remaining patients had either progressive, drug resistant disease or died early. One patient is currently alive and in complete remission at 20+ months. A second patient is alive at 20+ months in partial remission with traces of IgM-paraprotein still detectable. The main causes of death were tumor-lysis syndrom (4 patients) and therapy related sepsis with progressive tumor (3 patients). This poor outcome is probably due to a high proportion of high-risk patients and suboptimal therapy for this rapidly proliferating tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320885
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  • 13
    Electronic Resource
    Electronic Resource
    A multicentre study on intensive induction and consolidation therapy in acute myelogenous leukaemia (1988)
    Springer
    Annals of hematology 56 (1988), S. 233-236 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320111
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  • 14
    Electronic Resource
    Electronic Resource
    Pseudoreticulocytosis in a patient with myelodysplasia (1993)
    Springer
    Annals of hematology 67 (1993), S. 127-128 
    Details
    ISSN: 1432-0584
    Keywords: Myelodysplastic syndrome ; Reticulocytes ; Erythrocyte abnormalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with a myelodysplastic syndrome (MDS) and reticulocytosis of 〉50% in the absence of a correspondingly increased erythrocyte turnover is reported. Evaluation of the kinetics of erythrocyte turnover revealed a decreased erythrocyte life span of 44 days. From these data a prolongation of the reticulocyte maturation time to 〉20 days can be concluded. The patient's erythrocytes lacked the increase of mean corpuscular volume and a significant increase of erythrocyte enzymes that would be expected in marked reticulocytosis. This finding suggests that the reticulocytes represented not newly formed red blood cells, but “pseudoreticulocytes”, i.e., mature erythrocytes that retained their substantia reticulofilamentosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01701735
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  • 15
    Electronic Resource
    Electronic Resource
    High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia Long-term follow-up of a prospective multicenter trial (1995)
    Springer
    Annals of hematology 71 (1995), S. 219-225 
    Details
    ISSN: 1432-0584
    Keywords: Key words De novo AML ; Adults ; HD-Ara-C/DNR consolidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A total of 149 consecutive de novo AML patients aged 50 years or less (median age = 37 years) were enrolled in this prospective multicenter trial initiated in May 1985. All patients received the same induction and early consolidation therapy with daunorubicin (DNR), cytosine arabinoside (Ara-C), and etoposide (DAV). High-dose Ara-C/DNR therapy included Ara-C at 3 g/m2, in 12 doses (HD-Ara-C/DNR I) and eight doses (HD-Ara-C/DNR II), followed by DNR 30 mg/m2 for 3 days. A complete remission (CR) was achieved in 104 (70%) patients; 61 complete responders received at least one cycle with HD-Ara-C/DNR. If those patients who were transplanted in first CR (n = 26), were not considered, the median relapse-free-survival (MRFS) of the remaining 78 patients was 15 months, with a probability of relapse-free survival (RFS) at 116 months of 30% (95% CI, 20–40%) after a median follow-up of 95 months. The MRFS of the HD-Ara-C/DNR consolidated patients was 25 months, with a probability of RFS at 116 months of 37% (95% CI, 24–50%). If all patients who were transplanted (n = 44) were not considered, the median survival time (MST) was 18 months with a probability of being alive at 118 months of 24% (95% CI, 16–33%). MST of the HD-Ara-C/DNR consolidated patients was 58 months with a survival probability of 46% (95% CI, 31–60%) at 118 months. Prognostic factor analysis did not reveal any significant influence of age, sex, FAB subtype, white blood cell count, hemoglobin level, thrombocyte count, LDH, or response to the first induction course on RFS of the HD-Ara-C/DNR consolidated patients. In summary, HD-Ara-C/DNR consolidation can improve the long-term outcome of a subgroup of de novo AML patients. Further improvement of the outcome seems to depend on the identification of patients with an inferior outcome under that strategy who might benefit from alternative treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744371
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  • 16
    Electronic Resource
    Electronic Resource
    High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 219-225 
    Details
    ISSN: 1432-0584
    Keywords: De novo AML ; Adults ; HD-Ara-C/DNR consolidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 149 consecutive de novo AML patients aged 50 years or less (median age = 37 years) were enrolled in this prospective multicenter trial initiated in May 1985. All patients received the same induction and early consolidation therapy with daunorubicin (DNR), cytosine arabinoside (Ara-C), and etoposide (DAV). High-dose Ara-C/DNR therapy included Ara-C at 3 g/m2, in 12 doses (HD-Ara-C/DNR I) and eight doses (HD-Ara-C/DNR II), followed by DNR 30 mg/m2 for 3 days. A complete remission (CR) was achieved in 104 (70%) patients; 61 complete responders received at least one cycle with HD-Ara-C/DNR. If those patients who were transplanted in first CR (n=26), were not considered, the median relapsefree-survival (MRFS) of the remaining 78 patients was 15 months, with a probability of relapse-free survival (RFS) at 116 months of 30% (95% CI, 20–40%) after a median follow-up of 95 months. The MRFS of the HD-Ara-C/DNR consolidated patients was 25 months, with a probability of RFS at 116 months of 37% (95% CI, 24–50%). If all patients who were transplanted (n=44) were not considered, the median survival time (MST) was 18 months with a probability of being alive at 118 months of 24% (95% CI, 16–33%). MST of the HD-Ara-C/DNR consolidated patients was 58 months with a survival probability of 46% (95% CI, 31–60%) at 118 months. Prognostic factor analysis did not reveal any significant influence of age, sex, FAB subtype, white blood cell count, hemoglobin level, thrombocyte count, LDH, or response to the first induction course on RFS of the HD-Ara-C/DNR consolidated patients. In summary, HD-Ara-C/DNR consolidation can improve the long-term outcome of a subgroup of de novo AML patients. Further improvement of the outcome seems to depend on the identification of patients with an inferior outcome under that strategy who might benefit from alternative treatment strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744371
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  • 17
    Electronic Resource
    Electronic Resource
    Thrombotic thrombocytopenic purpura in early pregnancy with maternal and fetal survival (1992)
    Springer
    Annals of hematology 64 (1992), S. 245-248 
    Details
    ISSN: 1432-0584
    Keywords: Thrombotic thrombocytopenic purpura ; Pregnancy ; Plasma exchange ; Plasma infusions ; Antiplatelet agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder which is clinically characterized by thrombocytopenia, microangiopathic hemolytic anemia, fever, neurologic symptoms, and cardiac and renal involvement. The pathogenic mechanisms of this disease are poorly understood. It is well known that TTP is associated with pregnancy and that prognosis for the mother and child is poor. We present the first case of a severe TTP diagnosed in the first trimester of pregnancy (13th week of gestation) with maternal survival and birth of a healthy child which required continuous and intensive treatment with plasmatherapy until delivery. During a period of 24 weeks several attempts to discontinue plasma therapy failed because of continuous active disease, and it became evident that plasma infusions were not as effective as plasma exchanges. The fact that the patient entered into remission soon after delivery of a healthy child by cesarean section in the 37th gestational week shows that in this case pregnancy activated an unknown factor which does not cross the placenta and which can be removed by plasmapheresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01738304
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  • 18
    Electronic Resource
    Electronic Resource
    Antimicrobial prophylaxis in neutropenic patients after bone marrow transplantation (1988)
    Springer
    Infection 16 (1988), S. 19-24 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 41 Patienten mit malignen hämatologischen Systemerkrankungen oder schwerer Panmyelopathie wurden mit einer allogenen oder syngenen Knochenmarktransplantation behandelt und erhielten zur Infektprophylaxe während der Phase der Granulozytopenie entweder eine totale Dekontamination in strikt reverser Isolation (ITD, 26 Patienten) oder eine selektive Dekontamination des Gastrointestinaltraktes mit „barrier nursing“ (SD, 15 Patienten). Die Patienten wurden ausgewertet bezüglich erworbener Infektionen, Fiebertagen, Tagen unter antibiotischer Therapie und dem Bedarf an Granulozytentransfusionen 48 Stunden nach Beginn der Dekontamination bis zum Erreichen von 1000 Granulozyten/µl. Zehn von 26 Patienten mit ITD blieben frei von Fieberepisoden und Infektionen, während alle Patienten mit SD Infektionen entwickelten (p 〈 0.001). Während der Phase der Granulozytopenie hatten Patienten der Gruppe ITD weniger Fiebertage, waren seltener unter systemischer Antibiotikatherapie und erhielten weniger häufig Granulozytentransfusionen im Vergleich zu Patienten der Gruppe SD. Beide Methoden waren sehr effektiv in der Prophylaxe gramnegativer Infektionen, Infektionen durchStaphylococcus aureus und Pilzinfektionen. In keiner Gruppe trat eine tödliche Infektion auf. Die Ergebnisse dieser Studie zeigen, daß mit ITD im Vergleich zu SD eine effizientere antimikrobielle Prophylaxe bei Patienten mit Knochenmarktransplantation möglich ist.
    Notes: Summary Fourty-one patients with haematological malignancies or severe aplastic anaemia underwent allogeneic or syngeneic bone marrow transplantation and received one of two forms of infection prophylaxis while granulocytopenic: total decontamination in strict reverse isolation (ITD, 26 patients) or selective decontamination of the digestive tract with barrier nursing (SD, 15 patients). The patients were evaluated for infection acquisition, fever days, days on systemic antibiotics and granulocyte transfusions from 48 hours after the beginning of the decontamination procedure until 1,000 granulocytes/µl have been reached. Ten of 26 patients of the ITD group remained free of febrile episodes and infections, whereas all patients of the SD group acquired infections (p 〈 0.001). During granulocytopenia patients of the ITD group had fewer fever days, were less frequently on systemic antibiotics and received fewer granulocyte transfusions as compared with the SD group. Both methods were obviously very effective in preventing gram-negative infections, infections caused byStaphylococcus aureus and infections due to yeasts or fungi. No death due to infection occurred in either group. However, the data of this study provide evidence that ITD is a more effective antimicrobial prophylaxis in bone marrow transplant recipients than SD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646924
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  • 19
    Electronic Resource
    Electronic Resource
    Corynebacterium jeikeium bacteremia at a tertiary care center (1991)
    Springer
    Infection 19 (1991), S. 201-204 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer Universitätsklinik wurde während eines Zeitraumes von sechs Jahren bei 23 PatientenCorynebacterium jeikeium aus Blutkulturen isoliert.C. jeikeium-Bakteriämien traten weder zeitlich noch örtlich gehäuft auf. Die retrospektive Analyse der Patientendaten zeigte, daß in den meisten Fällen eine maligne hämatologische Grunderkrankung mit Neutropenie vorlag, ein zentral-venöser Katheter implantiert und eine antibiotische Therapie vorausgegangen war. Die Patientenpopulation mit nur einer positiven Blutkultur unterschied sich in wichtigen Aspekten von derjenigen mit mehreren positiven Blutkulturen. So waren Patienten mit nur einer positiven Blutkultur seltener an akuter Leukämie erkrankt, hatten signifikant höhere neutrophile Granulozytenkonzentrationen im peripheren Blut und waren zuvor über einen kürzeren Zeitraum antibiotisch behandelt worden. Weiterhin fanden sich in dieser Patientengruppe in allen Fällen andere mögliche Ursachen der Fieberepisoden. Auch die Mortalität war deutlich geringer. Trotz des zunehmend häufigeren Nachweises vonCorynebacterium jeikeium in Blutkulturen bleiben schwere Infektionen durch diesen Erreger weiterhin meist auf die Patientenpopulation mit hämatologischer Grunderkrankung und Neutropenie beschränkt.
    Notes: Summary During a six-year period 23 patients with isolation ofCorynebacterium jeikeium (formerly known asCorynebacterium group JK) from one or more blood cultures at a university hospital were identified. Cases occurred sporadically without time- or ward-related clustering. Review of the cases showed that most infections were nosocomial, that most of the patients had underlying malignant disease, had a chronic intravascular catheter implanted, had been pretreated with antibiotics, and were neutropenic at the time the blood cultures were drawn. Patients with only one versus those with more than one positive blood culture differed in some important aspects. Patients with only one positive blood culture were less likely to have acute leukemia, had significantly higher neutrophil counts and a shorter duration of preceding antibiotic treatment, and all had other probable causes of infection and fever. The mortality also appeared to be lower in these patients. Despite the possibility of increasing frequency of blood cultures positive forC. jeikeium, severe infections due to this organism continue to be largely confined to neutropenic patients with hematologic malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644945
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  • 20
    Electronic Resource
    Electronic Resource
    Prevention of infection in acute leukemia: A prospective randomized study on the efficacy of two different drug regimens for antimicrobial prophylaxis (1986)
    Springer
    Infection 14 (1986), S. 226-232 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer randomisierten Studie wurde die Wirksamkeit von zwei Verfahren der Infektionsprophylaxe an Patienten mit akuten Leukämien untersucht. Die Patienten erhielten entweder eine Kombination nicht resorbierbarer Antibiotika (Colistin und Neomycin) oder eine Kombination resorbierbarer und nicht resorbierbarer antimikrobieller Substanzen (Trimethoprim-Sulfamethoxazol [TMP-SMZ] und Colistin). Zur Pilzprophylaxe wurde in beiden Gruppen Amphotericin B oral eingesetzt. Beide Gruppen unterschieden sich nicht signifikant hinsichtlich des Anteils von Patienten mit erworbenen Infektionen und hinsichtlich des Zeitintervalls bis zur ersten erworbenen Infektion (p〉0,05). Septikämien traten bei neun von 49 Patienten auf, die Colistin und Neomycin erhielten, aber nur bei einem von 56 Patienten, die mit TMP-SMZ und Colistin behandelt wurden (p=0,03). Lokale Infektionen und Fieberepisoden ohne nachgewiesene Infektionen waren gleich häufig in beiden Gruppen. Die Häufigkeit von Fiebertagen und Tagen, an denen parenterale Antibiotika verabeicht wurden, war in der Gruppe, die TMP-SMZ und Colistin erhielt, signifikant geringer (p〈0,05). Kein signifikanter Unterschied fand sich bei der Dauer der schweren Granulozytopenie und Thrombozytopenie (p〉0,05).
    Notes: Summary In a prospective study patients with acute leukemia undergoing remission induction therapy were randomized to receive either a regimen of non-absorbable antimicrobial drugs (colistin and neomycin) or of absorbable and non-absorbable drugs (trimethoprim-sulfamethoxazole [TMP-SMZ] and colistin) for antibacterial prophylaxis. For antifungal prophylaxis patients in both groups were given oral amphotericin B. The proportion of patients without acquired infections and the median of study time to the first acquired infection did not differ significantly between the two treatment groups (p〉0.05). Septicemias occurred in nine out of 49 recipients of colistin and neomycin and in one out of 56 patients receiving TMP-SMZ and colistin (p=0.03). Localized infections and fever episodes without proven infections were equally distributed between the two groups. The incidence of febrile days and of days on parenteral antibiotic therapy was significantly lower in the group given TMP-SMZ and colistin (p〈0.05). The duration of severe granulocytopenia and thrombocytopenia did not differ significantly between the two groups (p〉0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644268
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