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  • 11
    Electronic Resource
    Electronic Resource
    The nature of lorazepam-induced amnesia (1984)
    Springer
    Psychopharmacology 83 (1984), S. 183-187 
    Details
    ISSN: 1432-2072
    Keywords: Benzodiazepine ; Lorazepam ; Amnesia ; Learning ; Memory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of lorazepam (2.5 mg) was assessed in two tests of short-term retention (digit-span and Benton Visual Retention), and in verbal learning and picture recognition tests. Lorazepam was without effect in a test of digit-span, but it impaired performance in the Benton Visual Retention and picture recognition tests. In the verbal learning test lorazepam caused a severe anterograde amnesia. Increasing arousal during the presentation of material partially overcame this effect, but also improved the performance of controls. Lorazepam-treated subjects were able to learn a backwards-reading task at a rate no different from controls. The deficits caused by lorazepam are similar to those that have been observed in patients with the amnesic syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429732
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    A late-appearing benzodiazepine-induced hypoactivity that is not reversed by a receptor antagonist (1986)
    Springer
    Psychopharmacology 88 (1986), S. 520-524 
    Details
    ISSN: 1432-2072
    Keywords: Benzodiazepine ; Sedation ; Locomotor activity ; Exploration ; Withdrawal ; Benzodiazepine antagonist ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The activity of rats in a holeboard test is reduced 30, 90, and 240 min after treatment with a single dose of lorazepam. The administration of a benzodiazepine antagonist (RO 15-1788) 20 min before the holeboard test (i.e., 10, 70, or 220 min after lorazepam administration) reverses the hypoactivity of animals tested 30 min after treatment with lorazepam, partially reverses the hypoactivity of animals tested 90 min after receiving lorazepam, but is without effect on the hypoactivity observed 240 min after treatment with the benzodiazepine. If, however, RO 15-1788 is given at the same time as lorazepam then it reverses the hypoactivity seen 4 h later. The results of these experiments demonstrate that a benzodiazepine can exert a behavioral effect at a time when it no longer appears to be acting at central benzodiazepine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178518
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    The effects of novelty, isolation, light and ethanol on the social behavior of mice (1988)
    Springer
    Psychopharmacology 96 (1988), S. 181-187 
    Details
    ISSN: 1432-2072
    Keywords: Social behavior ; Aggression ; Isolation ; Ethanol ; Light ; Motor activity ; Mouse ; Novelty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The social behavior of pairs of male NIH Swiss mice was assessed under a variety of experimental conditions. Increasing periods of isolation increased both the total time spent in social interaction and also increased the incidence of aggressive behavior. Familiarity with the testing arena tended to increase social behavior, but the magnitude of this effect was considerably less than that previously observed in rats. High light levels reduced social interaction. Ethanol (0.8–2.4 g/kg) caused a dose-related decrease in the total time spent in social interaction, a biphasic effect on aggressive behavior and a dose-related increase in locomotor activity. While the social interaction test in this form may not be a suitable model of anxiety in NIH Swiss mice, it should provide a useful method of assessing drug effects and investigating genetic influences on social and aggressive behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177558
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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