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  • 11
    Electronic Resource
    Electronic Resource
    Electron density in rutile (TiO2) by the maximum entropy method (1992)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 48 (1992), S. 591-598 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108768192001770
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  • 12
    Electronic Resource
    Electronic Resource
    Electron-density distribution from X-ray powder data by use of profile fits and the maximum-entropy method (1990)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 23 (1990), S. 526-534 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: Following the profile decomposition of CeO2 X-ray powder data into individual structure factors, the maximum-entropy method (MEM) has been used to obtain an electron-density-distribution map. In the profile decomposition process, it is impossible to avoid the problems of overlapping peaks which have the same magnitude of reciprocal vectors, such as d*(511) and d*(333), for a cubic crystal, or very severely overlapping reflections. The formalism to treat such overlapping reflections in the MEM analysis is to introduce combined structure factors. The maximum value of the scattering vector, 4π(sinθ)/λ, which was used in the present analysis is small (about 7.8 Å−1) but the resulting electron-density-distribution map is of a high quality and much superior to the conventional map. As a consequence, the ionic charge of Ce and O ions can be obtained with reasonable accuracy from the MEM density map. Furthermore, the map reveals the existence of electrons around the supposedly vacant site surrounded by eight O atoms, which is probably related to the high ionic conductivity of this substance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889890008214
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  • 13
    Electronic Resource
    Electronic Resource
    Knowledge-based speech pattern recognition - by Michael Allerhand. The Fifth Generation Computing Series, Kogan Page
    Amsterdam : Elsevier
    Computer Speech & Language 2 (1987), S. 367-368 
    Details
    ISSN: 0885-2308
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Linguistics and Literary Studies , Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0885-2308(87)90020-9
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  • 14
    Electronic Resource
    Electronic Resource
    High-affinity specific [3H]tamsulosin binding to α1 in human prostates with benign prostatic hypertrophy (1994)
    Springer
    Urological research 22 (1994), S. 273-278 
    Details
    ISSN: 1434-0879
    Keywords: [3H]Tamsulosin ; Radioreceptor assay ; Human prostates ; α1-antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The binding of a novel radioligand, [3H]tamsulosin, to human prostatic membranes with benign prostatic hypertrophy (BPH) has been characterized. [3H]Tamsulosin rapidly associated with its binding sites in human prostatic membranes with BPH, and the binding reached steady state by 30 min at 25°C. The rate constants for association and dissociation of [3H]tamsulosin binding were calculated to be 0.21±0.05/nM per minute and 0.01±0.004/min, respectively. The specific binding of [3H]tamsulosin in human prostatic membranes was saturable and of high affinity (K d=0.04±0.01 nM). The density of [3H]tamsulosin-binding sites (B max) was 409±28 fmol/mg protein. The K d and B max values for [3H]tamsulosin binding in human prostates were significantly lower than those for [3H]prazosin binding. [3H]tamsulosin binding was remarkable for its significantly lower degree of nonspecific binding. Six α-adrenoceptor antagonists competed with [3H]tamsulosin for the binding sites in the rank order: tamsulosin〉WB4101〉prazosin〉S-(+)-isomer〉naftopidil〉yohimbine. The binding affinities (pKi) of these antagonists for [3H]tamsulosin binding in human prostates closely correlated with their pharmacological potencies (pA2) in prostates. In conclusion, [3H]tamsulosin selectively labels α1-adrenoceptors in human prostates, and thus may become a useful radioligand for the further analysis of these receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297194
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  • 15
    Electronic Resource
    Electronic Resource
    Characterization of glycoprotein C-negative mutants of herpes simplex virus type 1 isolated from a patient with keratitis (1990)
    Springer
    Archives of virology 113 (1990), S. 195-207 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently three strains of herpes simplex virus type 1 (HSV-1), which did not react with MicroTrak Herpes (Syva Co.), were isolated by us from a patient with recurrent herpetic keratitis. In this study we characterized these strains of HSV-1 and found them to be HSV-1 gC− mutants which are very rare isolates from humans. The properties of the HSV-1 strains regarding plaque morphology on Vero cells and chick embryo fibroblasts and viral DNA analysis were the same as those of the usual HSV-1 strains. An immunofluorescence study using anti-gC-1 monoclonal antibody and SDS-PAGE analysis of radiolabeled viral glycoproteins showed that these strains are deficient in gC-1. They were virulent for mice and sensitive to acyclovir and bromovinyldeoxyuridine. Furthermore the infectivity of the strains was inactivated by complement though the phenomenon was not observed in the usual HSV-1 strains. This finding suggests that protection from damages by complement is an important function of gC. In keratitis the effects of complement are thought to be minimal because of the scanty blood supply and this may be the reason why these strains were isolated from the cornea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316673
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  • 16
    Electronic Resource
    Electronic Resource
    Necrotizing chorioretinitis in mice inoculated with herpes simplex virus type 1 with or without glycoprotein C: anterior chamber-associated immune deviation does not persist (1993)
    Springer
    Archives of virology 132 (1993), S. 225-236 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary BALB/c mice developed contralateral necrotizing retinitis following intracameral inoculation with herpes simplex virus type 1 (HSV-1). The animals showed a positive delayed-type hypersensitivity (DTH) response at 10 days postinoculation, indicating that the anterior chamber-associated immune deviation was transient after HSV-1 inoculation. Since glycoprotein C (gC) of HSV-1 is a major immunogen, we examined DTH and the antibody response induced by a gC-deficient strain TN-1 and compared them with those induced by the recombinant gC-positive mutants. We found that gC was not required for DTH reaction, and that gC was neither necessary for nor protective against the contralateral retinal necrosis. Serial lymphocyte subset analyses of the draining lymph nodes revealed an absolute increase of B cells, CD 4-positive T cells, and CD 8-positive T cells. CD 4-positive T cells but not CD 8-positive T cells increased in the contralateral eyes during the inflammation and necrosis. The coincident emergence of the positive DTH and contralateral retinal necrosis of HSV-1-inoculated mice, together with the presence of CD 4-positive cells in the retina, indicated that CD 4-positive T cells responsible for DTH induction may participate in the retinal necrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309535
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  • 17
    Electronic Resource
    Electronic Resource
    Microprocessor-based left ventricular cineangiogram analyser (1987)
    Springer
    Medical & biological engineering & computing 25 (1987), S. 212-218 
    Details
    ISSN: 1741-0444
    Keywords: Left ventricular cineangiograms ; Nonparametric discriminant analysis (NPDA) processor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442853
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  • 18
    Electronic Resource
    Electronic Resource
    Time-varying spline filter and its application to the left ventricular pressure measurement (1988)
    Springer
    Medical & biological engineering & computing 26 (1988), S. 88-91 
    Details
    ISSN: 1741-0444
    Keywords: Catheter/manometer system ; Left ventricular pressure ; Spine function ; Time-varying filter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441834
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  • 19
    Electronic Resource
    Electronic Resource
    Immunological and molecular comparison of simian cytomegaloviruses isolated from African green monkey (Cercopithecus aethiops) and Japanese macaque (Macaca fuscata) (1989)
    Springer
    Archives of virology 107 (1989), S. 65-75 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Simian cytomegaloviruses (CMV) isolated from African green monkeys and Japanese macaques were compared serologically and genetically. Twenty-three out of 31 sera from Japanese, Taiwan and rhesus macaques were positive for neutralizing antibodies to simian CMVs isolated from both African green monkeys and a Japanese macaque. The neutralizing antibody titers of those sera were slightly higher to the isolates of African green monkeys origin than to that of Japanese macaque origin. Studies with antisera prepared in guinea pigs revealed a partial antigenic cross-reaction between Japanese macaque CMV (JaM-CMV) and African green monkey CMV (AGM-CMV): the antiserum to JaM-CMV neutralized both homologous JaM-CMV and heterologous AGM-CMV, but the antisera to AGM-CMV neutralized only homologous AGM-CMV. DNAs of both AGM-CMV and JaM-CMV were compared by restriction endonuclease cleavage analysis. The individual simian CMV isolates showed unique restriction patterns when cleaved withEcoRI,BamHI, orHindIII. In addition, DNA of JaM-CMV was distinguishable from that of AGM-CMV when cleaved withEcoRI orBamHI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01313879
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  • 20
    Electronic Resource
    Electronic Resource
    Electron microscope observations on tubular structures in cells infected with herpes simplex virus type 2 (1976)
    Springer
    Archives of virology 50 (1976), S. 159-168 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of filamentous structures and lattice-like structures found in herpes simplex virus type 2-infected cells was studied. By specimen tilting experiments, it was demonstrated that the lattice-like structures were the cross-sectional views of the tubular structures and the filamentous structures were the longitudinal sections. The observation in negatively stained preparations of isolated tubular structures revealed that the structure was constructed by regular array of ring shaped elements. A hypothetical model is presented for tubular structures constructed on the basis of the present findings. The tubular structures appeared as early as 6 hours after infection and reached a maximum at 12 hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01318010
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