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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 154 (1995), S. 640-642 
    ISSN: 1432-1076
    Keywords: Key words Recurrent suppurative ; thyroiditis ; Pyriform sinus fistula ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute suppurative thyroiditis is a rare disease, particularly in childhood. We present a case with recurrent acute suppurative thyroiditis due to a pyriform sinus fistula originating from the fourth branchial pouch. The typical symptoms of a piriform sinus fistula are recurrent left-sided pain and swelling of the neck with signs of acute bacterial inflammation. Diagnosis should be made by high resolution ultrasound, barium meal studies and endoscopic examination. During acute exacerbations treatment with antibiotics is indicated, but permanent cure can only be attained by complete fistulectomy.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 158 (1999), S. 362-366 
    ISSN: 1432-1076
    Keywords: Key words Type 1 diabetes ; Children ; Risk factors ; Case control ; Environmental
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate environmental risk factors in the development of type 1 diabetes mellitus in a population-based case-control study. Parents of all patients with manifestation of type 1 diabetes between 1989 and 1994 in Vienna were asked to complete a questionnaire (n = 114). Control children (n = 495), matched for age and sex, were randomly recruited from all schools in Vienna. Fathers of diabetic children were significantly older at the time their children were born than fathers of control children (P = 0.015). Children with diabetes were more likely to be second- or third-born children (P 〈 0.05) and fewer went to kindergarten than the control group children (P = 0.007). No significant difference in duration of gestation, percentage of delivery by caesarean section, birth weight or length was found. Neonatal jaundice was more often observed in the patient group (P = 0.038). Breast feeding was reported by 82.7% of mothers of diabetic children and by 81% of mothers of control children, and the duration of breast feeding was longer in patients than in controls (n.s.). Conclusion In our study, the development of type 1 diabetes mellitus was associated with higher paternal age and neonatal jaundice. No correlation could be found with dietary intake of cow's milk products in early infancy, vaccination and other environmental factors.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 156 (1996), S. 15-17 
    ISSN: 1432-1076
    Keywords: Key words Insulin dependent diabetes ; Austrian ; Young cohort ; Population based mortality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract All Austrian patients with insulin dependent diabetes diagnosed between 1979 and 1990 and age at onset below 15 years were followed from manifestation until death or until 31 December 1990 by cross linking the diabetes registry data with the National Mortality database (death certificates). Out of the cohort consisting of 1185 cases, 6 had died during the study period, resulting in a standardized mortality ratio of 1.53 for the total cohort. Of the patients 50% died due to acute diabetic complications including 2 children at onset of the disease. The risk for premature death in this cohort of very young insulin dependent diabetes mellitus patients was only slightly increased. In comparison to previous studies it is rather low, but comparable to recent investigations in northern Europe. Conclusion Although the mortality of diabetic children and adolescents in Austria is only marginally higher than in nondiabetics, there are still deaths which should be preventable in this age group.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 156 (1997), S. 838-840 
    ISSN: 1432-1076
    Keywords: Key words: Insulin dependent diabetes mellitus ; Children ; Lispro insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared the postprandial blood glucose (BG)-levels following preprandial regular insulin or lispro insulin before and after eating in adolescents with diabetes. Lispro is a rapidly absorbed insulin analogue. Lispro insulin injected immediately before breakfast reduced the postprandial BG-rise significantly compared to the 20 min preprandially administered regular insulin (P〈0.01). Postprandial lispro injection resulted in similar BG values as the standard treatment with regular insulin 20 min preprandially. Conclusion Lispro insulin injected immediately before the meal leads to lower postprandial BG levels and seems to be an option for teenagers who use multiple preprandial insulin injections. Postprandial lispro administration could be a benefit in certain situations since it resulted in similar BG values to preprandial regular insulin.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 6 (1995), S. 569-576 
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Preterm premature rupture of the chorioamniotic membrane frequently leads to preterm birth and perinatal mortality. To ascertain whether the rupture of these membranes is influenced by variations in environmental pH and sodium concentration, we punctured 180 specimens from 9 membranes that were equilibrated in solutions of different pH, and 196 specimens from 10 membranes that were equilibrated in solutions with different sodium concentrations. Whole-membrane mechanical characteristics—strength, stiffness, toughness and ductility—were measured. These characteristics were defined based on a variant of the weakest-link theory: from a pool of three to five specimens, the specimen that had the lowest values of strength and concomitant values of stiffness, toughness, and ductility represents the mechanical characteristics of the entire membrane section. Strength-related mechanical characteristics—strength, stiffness and toughness—correlated negatively with pH (p〈0.001, p〈0.001, and p〈0.02, respectively), while ductility did not correlate significantly with pH. Membrane hydration and thickness correlated positively with pH (p〈0.001). The greatest increase in hydration accompanied by the greatest drop in strength, stiffness and toughness was observed between pH values of 3.68 and 5.58, suggesting that insufficient quantities of vaginal H+ could cause—as well as mark—premature rupture of the chorioamniotic membrane. No whole—membrane mechanical characteristics correlated significantly with changes in sodium concentration. Membrane hydration and thickness had slight positive correlations with sodium concentration (p〈0.05). Changes solely in the sodium concentration of the amniotic fluid during normal pregnancy are not sufficient to facilitate rupture at term.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 5 (1994), S. 130-137 
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: The mechanical characteristics of the chorioamniotic membrane were evaluated with a new burst test apparatus by rupturing 35 specimens that were taken from a sample of seven afterbirths. ‘Strength’, ‘stiffness’, ‘toughness’, and ‘ductility’ were measured. Mechanical characteristics did not change significantly with variation in thickness. While ductility should not correlate with thickness, the lack of a significant increase in strength, stiffness and toughness with an increase in thickness is most unusual and requires an explanation. Subsequently, an additional experiment, which was designed to ascertain the mechanical stability of membrane specimens with prolonged exposure to air, showed a dramatic increase in stiffness as membranes were allowed to dry. The increase in stiffness indicates that strength and toughness also increase with drying, provided that ductility remains constant. Thus, the degree of hydration of the membrane, which is reflected in thickness, regulates mechanical characteristics. The increase in the water content of certain amniotic layers has a lubricating effect on the amnion-chorion interface. This lubrication increases as term approaches. Thus, hydration must increase as gestation progresses, and strength, stiffness, and toughness must decrease until the membrane is weak enough to rupture at the end of gestation. Thus, hydration must increase as gestation progresses, and strength, stiffness, and toughness must decrease until the membrane is weak enough to rupture at the end of gestation.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 255 (1998), S. 256-258 
    ISSN: 1434-4726
    Keywords: Key words Cervical spine ; Diffuse idiopathic skeletal hyperostosis ; Ankylosing hyperostosis (Forestier’s ; disease) ; Laryngeal edema ; Dyspnea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diffuse idiopathic skeletal hyperostosis (DISH), or ankylosing hyperostosis (“Forestier’s disease”), is an ossifying diathesis of unknown etiology. Diagnosis is primarily radiologic: osseous bridging of at least four contiguous vertebral bodies, a radiolucent line between the deposited bone and the anterior vertebral surface, large osteophytes and preservation of disk height especially in the cervical and lumbar spine. Although DISH is found in 6–12% of autopsy cases, clinical features are rare and consist primarily of swallowing disorders. A case of DISH is reported in which excessively enlarged cervical osteophytes led to edema of the laryngeal inlet and consequent severe dyspnea, necessitating emergency tracheotomy. Surgical excision of the osteophytic masses resulted in relief of symptoms. Symptomatology, radiographic features and individual treatments are discussed, with the latter dependent on clinical symptoms.
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; children ; HLA-types ; heterogeneity symptoms at onset ; partial remission ; genetic susceptibility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1–19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR 2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented with Type 1 diabetes more evenly over the year; they also presented without incidence peaks at 7 years or 10–11 years, as seen especially in DR 3/4 patients. The DR 3 patients more often had mild disease with less ketonuria at diagnosis, less often ketoacidotic symptoms and more often a subsequent partial remission. The apparently more severe disease among diabetic girls may, at least to some extent, be explained by their higher prevalence of HLA-DR4. The differences found were similar in North America and Europe. The results suggest that Type 1 diabetes is a genetically heterogenous disease and that HLA-typing may be a useful marker of this heterogeneity.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 262 (1978), S. 7-14 
    ISSN: 1432-069X
    Keywords: Black skin ; Actinic elastosis ; Light- and electronmicroscopy ; Fibroblastic product ; Negerhaut ; Aktinische Elastose ; Licht- und Elektronenmikroskopie ; Fibroblastenprodukt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 9 hautgesunden südafrikanischen schwarzen Freiwilligen im Alter von 1–72 Jahren wurde sonnenlichtexponierte und nichtexponierte Haut licht- und elektronenmikroskopisch untersucht unter besonderer Berücksichtigung altersabhängiger und aktinisch bedingter Veränderungen dermaler Strukturen. Während bei einer 72jährigen Frau eine ausgeprägte aktinische Elastose im oberen Corium der sonnenexponierten Haut licht- und elektronenoptisch nachweisbar war, fand sich bei einem 72jährigen Mann eine nur elektronenoptisch darstellbare geringe Elastose. Im Gegensatz dazu waren bei diesen beiden Fällen im unteren Corium der sonnenexponierten und in allen Schichten der nichtexponierten Haut nur altersentsprechende elastische Fasern vorhanden. Diese Beobachtungen stehen in Gegensatz zu der noch gängigen Auffassung, daß eine aktinische Elastose bei der kongoiden Rasse nicht auftritt. Das elastotische Material ist offensichtlich ein de-novo-synthetisiertes und sezerniertes pathologisches Produkt von (durch chronische UV-Bestrahlung) alterierten Fibroblasten.
    Notes: Summary In 9 otherwise dermatologically normal South African Black volunteers (1–72 years old), sunlight-exposed and non-exposed skin has been examined by light- and electronmicroscopy with special references to age-dependent and actinic alteration of dermal structures. Two 72 year old Blacks exhibited typical dermal elastosis: in 1 case to a marked extent and already detectable by lightmicroscopy, in the other case only to a mild degree. In contrast, only age-related elastic fibers were revealed in the lower dermis of sunlight-exposed skin and in all dermal layers of unexposed skin. These observations are contradictory to the general view that actinic elastosis does not occur in Blacks. The elastotic material is obviously a de-novo synthesized and secreted pathological product of chronically UV-altered fibroblasts.
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 1432-5233
    Keywords: Insulin-dependent diabetes ; Islet cell antibodies ; Complement-fixing ICA ; C-peptide ; Geographical variation ; Seasonal variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Finland and Sweden have the highest incidence of insulin-dependent diabetes in children in the world, about 3–4 times that of countries in the Mediterranean area, with the exception of Sardinia. We have collected information from several European clinics and from Pittsburgh, USA, in order to find out whether this difference in incidence is associated with corresponding differences of the disease pattern. Patients in Finland or Sweden (‘North’) and Pittsburgh were younger (〈10 years old) at diagnosis compared with those in the other clinics in Europe (P〈0.05 versusP〈0.02). In the North, boys were in excess (58%) in contrast to France (40%) and Pittsburgh (46%). Patients in the North had a shorter duration of symptoms (〈8 days;P〈0.001) and higher blood glucose (〉20 mmol/l;P〈0.05) than those attending the other European clinics. Irrespective of age, there were more ICA-positive patients in the North (94%) than in Berlin-Vienna (67%;P〈0.01) or in France (70%;P〈0.01). There was a tendency for non-diabetic parents and siblings in the North to have lower C-peptide values (〈0.26 pmol/ml) at the time of diagnosis of the proband and to be ICA-positive more often than relatives in the other European clinics. The seasonal variation of diagnosis, showed no obvious geographical differences, with recorded diagnosis always lowest during the summer. We conclude that certain factors seem to cause not only a high incidence of diabetes in children in Finland and Sweden but perhaps also a more aggressive early disease process.
    Type of Medium: Electronic Resource
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