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  • 11
    Electronic Resource
    Electronic Resource
    Non-peptide-based inhibitors of human immunodeficiency virus-1 protease
    Amsterdam : Elsevier
    Bioorganic & Medicinal Chemistry Letters 4 (1994), S. 2601-2604 
    Details
    ISSN: 0960-894X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80292-4
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  • 12
    Electronic Resource
    Electronic Resource
    The quadrupole coupling tensor of methyl amine
    Amsterdam : Elsevier
    Chemical Physics Letters 196 (1992), S. 155-158 
    Details
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-2614(92)85946-8
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  • 13
    Electronic Resource
    Electronic Resource
    The microwave spectrum and molecular structure of the ethylene-ozone van der Waals complex (1989)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 111 (1989), S. 3073-3074 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00190a056
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  • 14
    Electronic Resource
    Electronic Resource
    Carbon isotope fractionations in natural gases (1974)
    [s.l.] : Nature Publishing Group
    Nature 251 (1974), S. 134-135 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The results of isotope analyses of natural gases from Japan1, Taiwan2, Italy3 and the DDR4 are compared with isotope measurements of gases from the Federal Republic of Germany5 The German gases were taken from different geological formations and wells of the north-western German oil and gas ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/251134a0
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  • 15
    Electronic Resource
    Electronic Resource
    CALCIUM MOVEMENTS IN BRAIN SLICES IN LOW SODIUM OR CALCIUM MEDIA (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Movement of 45Ca into and out of cerebral slices in vitro was altered by incubation in Na-free medium or in the presence of ouabain. 45Ca uptake into the ‘non-inulin’ space was more than doubled in slices that were losing Na into Na-deficient media. Replacement of Na in the incubation medium by choline chloride reduced the efflux of 45Ca into Ca-free medium. In the presence of ouabain (10-4M), the rate of efflux was also reduced. NaCN or NaCN plus ethacrynic acid increased the rate of 45Ca efflux. The data are compatible with a sodium-calcium exchange mechanism in cerebral slices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb01294.x
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  • 16
    Electronic Resource
    Electronic Resource
    SODIUM STIMULATED [14C]ADENOSINE DIPHOSPHATE-ADENOSINE TRIPHOSPHATE EXCHANGE ACTIVITY IN BRAIN MICROSOMES (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 15 (1968), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An ADP-ATP exchange reaction was studied in NaI-treated microsomes from rat brain. At low concentrations of MgCl2 a nucleotide exchange reaction, elicited in the presence of Na+, had an absolute specificity for ATP. The reaction was stimulated by oligomycin and inhibited by ouabain and EDTA. It is probable that this Na+-stimulated ADP-ATP exchange reaction is a component of the Na-K ATPase system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1968.tb08948.x
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  • 17
    Electronic Resource
    Electronic Resource
    MOVEMENTS OF CALCIUM AND OTHER CATIONS IN ISOLATED CEREBRAL TISSUES (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Slices of guinea pig cerebral cortex were incubated in bicarbonate- or trisbuffered media. Influx of 45Ca2 +, 54Mn2 +, 133Ba2+ or 90Sr2+ was determined at intervals following addition of the cardiac glycoside, ouabain, to the medium. After incubation for 30 min in the presence of 45Ca2+ and in the absence of ouabain, about 40 per cent of the slice calcium became labelled. Ouabain (01 I″M) markedly increased 45Ca2 + content, as well as the content of unlabelled Ca2 +. Mg2+ and Na+ levels also rose while K+ content dropped at a more rapid rate. Ouabain also brought about increased uptake of 90Sr2+, 133Ba2 + and 54Mn2 +. Lowering the Na+ content of the media prevented the effects of ouabain and brought about an increase in calcium content of brain slices. Addition of 2,4-dinitrophenol (01 mM) or iodoacetate (1 miu) had slight or moderate effects on 45Ca2+ uptake. The data are most compatible with the presence in cerebral tissue of a sodium-calcium exchange process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb11969.x
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  • 18
    Electronic Resource
    Electronic Resource
    SUBCELLULAR DISTRIBUTION OF CEREBRAL CHOLE-STANOL IN CEREBROTENDINOUS XANTHOMATOSIS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Frozen frontal lobe from a patient with cerebrotendinous xanthomatosis and two control specimens were separated by differential centrifugation into subcellular fractions. The fractions were differentiated by their electron microscopic appearance, by their succinate dehydrogenase and acetylcholinesterase activities and by their galactolipid contents. Free cholestanol was present in largest amounts in the myelin fraction and was also found in each subcellular fraction prepared from the cerebrotendinous xanthomatosis brain. Thus, in this condition, cholestanol storage is a property of myelin and probably also of other brain membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb11968.x
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  • 19
    Electronic Resource
    Electronic Resource
    SUBCELLULAR FRACTIONATION OF POSTMORTEM BRAIN (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Procedures used to separate subcellular organelles from fresh brain were applied to brains which had been removed from guinea pigs (1) immediately after death; (2) after the dead animal was maintained at room temperature for 3 h, followed by 16–17 h at 4°C; or (3) after the dead animal was maintained for 19–20 h at room temperature. Subcellular fractionation of the brains in 0.32 M sucrose was followed by discontinuous density gradient centrifugation of the crude mitochondrial fraction. After overnight storage of brains at room temperature, there was a moderate shift in succinate dehydrogenase activity from sub-fraction C (mitochondria) to subfraction B (synaptosomes). There was little change in the distribution of galactolipid among particulate subfractions. There was little change in distributions of monoamine oxidase or acetylcholinesterase activities. Under the less extreme postmortem conditions, there were no shifts in the subcellular distributions of brain enzymes. Ultrastructural changes were much more profound and consisted of losses of identifiable mitochondria and synaptosomes and a progressive increase in very dense bodies. Our results suggest that in spite of the marked morphological changes, meaningful separation of subcellular organelles can be achieved with postmortem tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb12145.x
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  • 20
    Electronic Resource
    Electronic Resource
    THE SUBCELLULAR DISTRIBUTION AND NUCLEOTIDE SPECIFICITIES OF Na+, K+-STIMULATED ADENOSINE TRIPHOSPHATASE AND [14C]ADENOSINE DIPHOSPHATE-ADENOSINE TRIPHOSPHATE EXCHANGE REACTIONS IN RAT BRAIN (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 15 (1968), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: (1) The subcellular distributions of Na-K ATPase and [14C]ADP-ATP exchange activities were studied in rat brain. The data presented are not consistent with a discrete localization of these enzymes in any given fraction, but nerve endings and microsomes had similar specific activities. The supernatant fraction had the highest exchange and the lowest Na-K ATPase activities, measured at a concentration of 3 mm-MgCl2.(2) Nucleotide specificity of the Na-K ATPase was determined in all fractions, and this enzyme system showed an absolute requirement for ATP. The [14C]ADP-ATP exchange, measured at 3mm-MgCl2, possessed broader specificity and also was active toward ITP, UTP and GTP; this serves to differentiate it from the Na-K ATPase.(3) Treatment of nerve ending fractions with NaI medium removed the bulk of the [14C]ADP-ATP exchange activity without loss in Na-K ATPase activity.(4) The exchange activity in NaI-insoluble fractions was insensitive to NaCl in the presence of 3 mm-MgCl2, but it was stimulated 502-820 percent at low MgCl2 concentrations, a finding which may be consistent with the postulated role of this exchange reaction in the Na-K ATPase system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1968.tb08947.x
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