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  • 1
    Digitale Medien
    Digitale Medien
    Decreased Ferritin Levels in Brain in Parkinson's Disease (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 55 (1990), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Ferritin levels were measured in postmortem brain tissue from patients dying with Parkinson's disease [treated with L-3,4-dihydroxyphenylalanine (L-DOPA)] and from control patients. Ferritin levels were decreased in the substantia nigra, caudate-putamen, globus pallidus, cerebral cortex, and cerebellum when compared with age-matched control tissues. However, in CSF from L-DOPA-treated patients and in serum from L-DOPA-treated and untreated parkinsonian patients, ferritin levels were normal. Previous studies have suggested an increased total iron content in substantia nigra of parkinsonian brain. The failure of substantia nigra ferritin formation to be stimulated by increased iron levels suggests some defect in iron handling in this critical brain region in Parkinson's disease. The reason for decreased ferritin levels throughout the parkinsonian brain is not clear but does not seem to reflect a general system deficit in ferritin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1990.tb08814.x
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  • 2
    Digitale Medien
    Digitale Medien
    Photochemical core manipulation in high-nuclearity osmium-mercury clusters (1991)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 8698-8704 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja00023a017
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  • 3
    Digitale Medien
    Digitale Medien
    Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8-Hydroxyguanine Levels in Substantia Nigra (1997)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 69 (1997), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Oxidative damage has been implicated in the pathology of Parkinson's disease (PD), e.g., rises in the level of the DNA damage product, 8-hydroxy-2′-deoxyguanosine, have been reported. However, many other products result from oxidative DNA damage, and the pattern of products can be diagnostic of the oxidizing species. Gas chromatography/mass spectrometry was used to examine products of oxidation and deamination of all four DNA bases in control and PD brains. Products were detected in all brain regions examined, both normal and PD. Analysis showed that levels of 8-hydroxyguanine (8-OHG) tended to be elevated and levels of 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FAPy guanine) tended to be decreased in PD. The most striking difference was a rise in 8-OHG in PD substantia nigra (p = 0.0002); rises in other base oxidation/deamination products were not evident, showing that elevation in 8-OHG is unlikely to be due to peroxynitrite (ONOO−) or hydroxyl radicals (OH•), or to be a prooxidant effect of treatment with l-Dopa. However, some or all of the rise in 8-OHG could be due to a change in 8-OHG/FAPy guanine ratios rather than to an increase in total oxidative guanine damage.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1997.69031196.x
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  • 4
    Digitale Medien
    Digitale Medien
    Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’ (1978)
    Springer
    Psychopharmacology 57 (1978), S. 33-38 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Monoamine oxidase inhibitor ; Monoamine oxidase ; ‘Cheese effect’ ; Depression ; Parkinson's disease ; Levodopa ; Phenylethylamine ; Dopamine ; Deprenyl
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract After pretreatment with the selective monoamine oxidase B inhibitor, (-)-deprenyl, in doses sufficient for complete inhibition of the platelet enzyme, 4 normal and 6 parkinsonian volunteers (2 receiving levodopa and 2 levodopa plus carbidopa) suffered no adverse pressor reaction (‘cheese effect’) after challenge with oral tyramine in amounts considerably greater than those likely to be encountered in a normal diet. Nor did the levodopa-deprenyl combination itself result in a pressor response. Normal human intestinal mucosa was shown predominantly to contain the deprenyl-insensitive A form of the enzyme, which presumably degraded administered tyramine in the deprenyl-treated volunteers; even those receiving the drug for prolonged periods manifested no ‘cheese effect’, suggesting that the A form remained uninhibited. Intestinal monoamine oxidase A was able to oxidise dopamine, whereas in human platelet or striatum the amine is a monoamine oxidase B substrate. Like tyramine, oral phenylethylamine challenge with amounts greater than those known to be present in a normal diet similarly gave rise to no adverse reaction in (-)-deprenyl-treated subjects; the reasons for this remain to be determined.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00426954
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  • 5
    Digitale Medien
    Digitale Medien
    The progression of idiopathic Parkinson's disease is not explained by age-related changes. Clinical and pathological comparisons with post-encephalitic parkinsonian syndrome (1987)
    Springer
    Acta neuropathologica 73 (1987), S. 195-201 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Post-encephalitic parkinsonian syndrome (PEPS) ; Idiopathic Parkinson's disease (PD) ; Substantia nigra ; Age ; I-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In 12 cases of post-encephalitic parkinsonian syndrome (PEPS) starting at a mean age of 25.1 years, the mean disease duration of 35.8 years was twice as long as in 12 young patients with Lewy body-Parkinson's disease (LB-PD), whose disease started at a mean age of 39.9 years (mean duration 16.5 years). In PEPS the rate of progression of disease was extremely slow. The groups were of a similar age at death, but the post-encephalitic cases had 70% fewer cells in the substantia nigra than in idiopathic Parkinson's disease (PD) and 92% fewer than in controls. Nigra cell destruction was not found in PEPS, but active cell breakdown and abundant extraneuronal melanin were present in PD. A second group of 12 LB-PD cases with mean onset at 58.9 years survived for a mean of 10.1 years, but the number of remaining substantia nigra cells was the same as in the young onset cases of PD. This clinical and pathological evidence does not support the notion that progression of disease in PD can be attributed to the superadded effects of normal ageing on top of a primary acute noxious insult sustained in earlier life.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00693789
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  • 6
    Digitale Medien
    Digitale Medien
    Thermal decomposition of palladium-imidazole complexes (1989)
    Springer
    Journal of thermal analysis and calorimetry 35 (1989), S. 147-152 
    Details
    ISSN: 1572-8943
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung In einer Reaktion von PdCl2 mit Imidazol wurde bei einem metall-Ligandenverhältnis von 1∶2 bzw. 1∶4 zwei Pd-Imidazolkomplexe dargestellt. Auf Grund der Ergebnisse von Elementaranalyse und Thermogravimetrieuntersuchungen besitzen die Verbindungen die Formeln Pd(IMDAH)2Cl2·4H2O bzw. Pd(IMDAH)3Cl2 (IMDAH=Imidazol). Der Mechanismus der thermischen Zersetzung dieser Komplexe in Luft umschliesst eine anfängliche Dissoziation (Abgabe von Wasser und IMDAH-Liganden) im Temperaturbereich 120–340 °C, gefolgt von der Bildung von PdO unter Abspaltung der Chloratome bei 530–570 °C sowie die letztendliche Bildung von metallischem Pd bei 820–840 °C.
    Kurzfassung: Резюме Взаимодействием хло ристого палладия и имидазола, взятых в со отношениях 1∶2 и 1∶4, получены имидазоль ные комплексы паллад ия. Элементный анализ и термогравиметричес кие аналитические да нные для этих соединений показали, что они имеют состав Рd(имидазол)2Сl2· 4Н2О и Рd(имидазол)3Сl2. Термическое разложе ние этих комплексов на воздухе сопровожд ается сначала выделе нием воды и имидазола в интервал е температур 120–340°, а затем атомов хло ра и образованием оки си палладия при темпера туре 530–570°. Конечным продуктом р еакции является обра зование металлического палл адия при 820–840°.
    Notizen: Abstract Two Pd-imidazole complexes have been synthesized following the reaction of PdCl2 and imidazole at 1∶2 and 1∶4 metal∶ ligand ratios. Elemental and thermogravimetric analytical data obtained from these compounds illustrate that they have the formulae Pd(IMDAH)2Cl2 · 4H2O and Pd(IMDAH)3Cl2 (IMDAH = imidazole), respectively. The mechanism of thermal decomposition for these complexes in air involves initial dissociation of H2O and IMDAH ligands in the 120–340 °C range, subsequent dissociation of the chloride atoms to form PdO in the 530–570 °C range, and finally formation of Pd metal at 820–840 °C.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01914274
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  • 7
    Digitale Medien
    Digitale Medien
    Stuttering, tic-like facial movements and behavioural disorders (1996)
    Springer
    Journal of neurology 243 (1996), S. 105-106 
    Details
    ISSN: 1432-1459
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00878543
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  • 8
    Digitale Medien
    Digitale Medien
    Editorial (1998)
    Springer
    Journal of neurology 245 (1998), S. S1 
    Details
    ISSN: 1432-1459
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00007729
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  • 9
    Digitale Medien
    Digitale Medien
    Multiple sclerosis leading to blepharospasm and dystonia in a sibling pair (1996)
    Springer
    Journal of neurology 243 (1996), S. 667-670 
    Details
    ISSN: 1432-1459
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00878668
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  • 10
    Digitale Medien
    Digitale Medien
    Treatment of cervical dystonia hand spasms and laryngeal dystonia with botulinum toxin (1992)
    Springer
    Journal of neurology 239 (1992), S. 1-4 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Cervical dystonia ; Hand spasms ; Laryngeal dystonia ; Botulinum toxin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary One hundred and twenty-six patients with different forms of focal dystonia (89 with cervical dystonia, 12 with hand cramps and 25 with laryngeal dystonia) were treated with localised injections of botulinum toxin. Mean doses per muscle were 200 mouse units (m.u.) for treating cervical dystonia, 40–120 m.u. for forearm muscles in writers' cramp and 3.7 m. u. for the thyroarytenoid muscle in laryngeal dystonia. Responder rates have been above 80% in all patient groups and beneficial effects could be reproduced over follow-up periods of up to 4 years. The commonest side-effects were dysphagia after treatment of spasmodic torticollis, weakness of neighbouring muscles after injections for hand cramps and breathiness and hypophonia following laryngeal injections. All these were transient and generally well tolerated. It is concluded that botulinum toxin injections are a safe and effective treatment in all three types of focal dystonia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00839202
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