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  • 1965-1969  (2)
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  • 1
    Digitale Medien
    Digitale Medien
    Studies on interferon induction by Newcastle disease virus (NDV) (1969)
    Springer
    Archives of virology 28 (1969), S. 177-187 
    Details
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Seed stock of Newcastle disease virus (NDV) prepared by infecting primary chick embryo (PCE) cells (CE-NDV) induced interferon production in PCE cells. Unlike the case of egg-grown NDV (EG-NDV), UV irradiation of CE-NDV resulted in a linear decrease of interferon inducing potency. The interferon induction by CE-NDV was not a strain-specific characteristic, seemed to be associated with viral growth, and was interfered by an excess dose of EG-NDV in its very early period of infection. Little has been elucidated about the mechanism which governs the alteration between EG- and CE-NDV type of interferon stimulation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01249382
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Studies on interferon induction by Newcastle disease virus (NDV) (1969)
    Springer
    Archives of virology 28 (1969), S. 188-196 
    Details
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Heat- and acid-treatments of EG-NDV, which was essentially a very poor inducer of interferon in PCE cells, resulted in the development of the potency to stimulate interferon synthesis. Optimum temperature to bring about the activation was 56° C, and the peak of the potency was obtained after 4–6 minutes. Effective pH range was 1.6–2.5. Neutral and alkaline pH did not exhibit the stimulatory effect. A hypothetical mechanism to interprete the observed facts is presented, which assumes a heat- and acid-labile component in the virion inhibitory to the induction or synthesis of interferon in PCE cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01249383
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
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