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  • 1995-1999  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Modulation ofin vivo neuronal sprouting by serotonin in the adult CNS of the snail (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 561-576 
    Details
    ISSN: 1573-6830
    Schlagwort(e): buccal ganglia ; neurite outgrowth ; supernumerary fibres ; cyproheptadine ; molluscs
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary 1. Duringin situ recovery from a lesion to the cerebrobuccal connective (CBC) in the snailAchatina fulica, neurons of the buccal ganglia undergo extensive regeneration and sprouting as assessed by axonal dye-fillings of the CBC. 2. These changes are preceded by the distal degeneration of severed fibres from the serotonergic metacerebral giant neuron (MCG), which results in the depletion of serotonin (5-HT) in the ipsilateral buccal ganglion. We have investigated the potential role of this depletion in causing some of the ensuing neuroplastic events. 3. Pharmacological depletion of 5-HT using either 5,7-dihydroxtryptamine or p-chlorophenylalanine in normal, unlesioned animals was found to produce supernumerary neuronal labelling similar to that seen following a lesion. 4. Systemic daily injections of 5-HT were found to partly suppress the sprouting response following the CBC lesion. For example, the contralateral uninjured MCG which is normally induced by the lesion to sprout novel projections into the denervated ganglion, is suppressed from doing so by the 5-HT treatment. 5. These growth inhibiting effects of 5-HT upon the contralateral MCG could be antagonized by the prior administration of the 5-HT receptor blocker cyproheptadine, suggesting a specific receptor mediated action. 6. We suggest that 5-HT may play a role in governing the state of neuronal outgrowthin vivo in the CNS of the adult snail, as has been suggested by early developmental and neuronal cultural studies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02152057
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Tyrosine hydroxylase-negative, dopaminergic neurons are targets for transmitter-depleting action of haloperidol in the snail brain (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 451-461 
    Details
    ISSN: 1573-6830
    Schlagwort(e): antipsychotic ; neuroleptic ; gastropod ; monoamine ; catecholamine ; serotonin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary 1. The effects of long term administration of micromolar concentrations of the D2 antagonist haloperidol upon monoaminergic neurons in the snailLymnaea stagnalis was investigated. 2. Treatment by bath application with 0.5–2.0 micromolar haloperidol, caused a significant, continuous depletion of dopamine levels in the nervous system as revealed by high performance liquid chromatography. 3. A transient depletion of serotonin was also observed, but DOPA and norepinephrine levels were unaffected. Similar depletion of dopamine was observed after the land snail,Achatina fulica, was injected with haloperidol on each of 4 consecutive days. 4. The depletion of dopamine as revealed with glyoxylate-induced fluorescence inLymnaea appears to be restricted to a subpopulation of catecholaminergic neurons which are immuno-negative for tyrosine hydroxylase, the synthetic enzyme responsible for the conversion of tyrosine to DOPA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02150226
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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