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  • 1
    Electronic Resource
    Electronic Resource
    T-Cell Receptor Gene Usage of Acetylcholine Receptor-specific T-Helper Cells (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 681 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb22904.x
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  • 2
    Electronic Resource
    Electronic Resource
    Immunogenetics of glomerulonephritis (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 822-824 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190329
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  • 3
    Electronic Resource
    Electronic Resource
    In vivo induction of HLA molecules in patients with myeloproliferative syndrome during IFNα treatment (1991)
    Springer
    Annals of hematology 63 (1991), S. 259-263 
    Details
    ISSN: 1432-0584
    Keywords: HLA antigens ; Regulation in vivo ; Interferon ; Myeloproliferative syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eighteen patients with myeloproliferative syndrome (14 with chronic myeloid leukemia, four with essential thrombocytosis) were investigated for modulation of HLA antigens on peripheral blood lymphocytes, monocytes, and hematopoietic precursors during IFNα therapy as a sign of potentially increased immune recognition of malignant cells. After 1 month of IFNα therapy, an increased number of monocytes and hematopoietic precursor cells, but not of lymphocytes, expressed HLADQ antigens. In addition, a strong induction of HLA class-I antigens was found on both hematopoietic progenitors and normal peripheral blood mononuclear cells. With daily injections of IFN in the first month of therapy stimulation continuously increased, suggested a major effect of IFNa on hematopoietic progenitors with sustained enhanced expression of HLA class-I antigens during differentiation of myelomonocytic cells. HLA class-I antigen expression was consistently augmented by IFNα in all patients, irrespective of their hematological response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01698375
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  • 4
    Electronic Resource
    Electronic Resource
    Phenotypic and clinical heterogeneity of CD56-positive acute nonlymphoblastic leukemia (1992)
    Springer
    Annals of hematology 64 (1992), S. 78-82 
    Details
    ISSN: 1432-0584
    Keywords: Immunophenotype ; CD56 ; Acute non-lymphoblastic leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The precise phenotype and clinical course are described of a subgroup of acute nonlymphoblastic leukemias (ANLL) expressing the NK-cell differentiation antigen CD56. As previously reported, CD56+ leukemias occurred in a frequency of about 20% of ANLL cases showing clinical and immunophenotypical heterogeneity. Carrying various myelomonocytic markers, all cases were diagnosed to be of nonlymphoid origin. Positive or negative expression of CD34 allowed us to distinguish two major subtypes of CD56+ leukemias representing immature and more differentiated cells carrying further differentiation antigens (CD14 and/or CD15) of the myelomonocytic lineages. These phenotypes correlated with the M0, M2, M4, and M5 leukemias of the FAB classification.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715349
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of human cytomegalovirus on immune reconstitution after bone marrow transplantation (1992)
    Springer
    Annals of hematology 64 (1992), S. A140 
    Details
    ISSN: 1432-0584
    Keywords: Cytomegalovirus infection ; Bone marrow transplantation ; Graft-versus-host disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary HCMV infection diagnosed by the highly sensitive polymerase chain reaction (PCR) technology in blood, urine and skin biopsies of patients after bone marrow transplantation (BMT) correlated with the reconstitution of peripheral blood lymphocytes and dermal immunohistological alterations to evaluate the interaction of viral infection with the recovery of the immune system, as well as with the induction or aggravation of graftversus-host disease (GVHD). In a prospective study 73% of 63 patients showed viremia at a median time of 25 days after BMT. Only 44% of these cases that also presented with a higher frequency of acute GVHD symptoms developed HCMB disease later on. In the skin, similar immunohistological alternations, as well as frequent primary local HCMV infection before the development of cutaneous signs of GVHD, was found, suggesting the direct involvement of anti-HCMV immune responses in the induction of GVHD-associated organ lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715368
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  • 6
    Electronic Resource
    Electronic Resource
    Adhesion molecules on CD 34+ hematopoietic cells in normal human bone marrow and leukemia (1992)
    Springer
    Annals of hematology 65 (1992), S. 169-174 
    Details
    ISSN: 1432-0584
    Keywords: Adhesion molecules ; Leukemia ; CD 34 ; Phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Expression of selected adhesion molecules of the integrin and immunoglobulin family was investigated on CD 34+ leukemic cells in 19 AML and 11 ALL cases to evaluate phenotypic differences in adhesive properties of malignant hematopoietic precursor cells in comparison to normal bone marrow CD 34+ cells. Of the β2-integrin family, CD 11a was expressed on 〉 50% of CD 34+ cells in normal bone marrow and almost all leukemias, whereas CD 11 b and CD 11 c were not expressed on CD 34+ cells in normal bone marrow, but were found on CD 34+ blasts in some leukemias of a heterogeneous immunophenotype. Of the β 1-family, CDw 49d (VLA-4) was strongly expressed on normal CD 34+ bone marrow cells and on the blasts of all 30 CD 34+ leukemic samples, whereas CDw 49 b (VLA-2) was absent on CD 34+ cells in normal bone marrow, but detected on CD 34+ cells in a few leukemias which did not constitute a clinical or phenotypic entity according to the FAB classification or immunocytological analysis. The lymphocyte-homing-associated adhesion molecule CD 44 (HCAM) and CD 58 (LFA-3) were expressed on CD 34+ cells in all investigated cases of normal and leukemic bone marrow. ICAM-1 (CD 54), the inducible receptor ligand for CD 11 a/CD 18, although present on CD 34+ cells in normal bone marrow, was lacking on blast cells of some ALL and AML cases. So far, the variable expression of β2-integrins as well as of VLA-2 and of ICAM-1 could indicate distinct differences in cell-cell or cell-matrix adhesion of leukemic cells in ALL and AML patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703110
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  • 7
    Electronic Resource
    Electronic Resource
    Acute gallstone pancreatitis (1999)
    Springer
    Surgical endoscopy and other interventional techniques 13 (1999), S. 1070-1076 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Acute pancreatitis — Cholelithiasis — Endoscopic retrograde cholangiography — Laparoscopic cholecystectomy — Surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In acute gallstone pancreatitis, the ideal point in time for laparoscopic cholecystectomy with special reference to the severity of the disease has been prospectively analyzed. Methods: A total of 77 patients with biliary acute pancreatitis were admitted between November 1993 and July 1998 (37 men and 40 women; mean age, 63 years; median Apache II score, 13.3) and staged by contrast-enhanced computed tomography findings as having edematous or necrotizing disease. Results: In 48 patients, laparoscopic cholecystectomy was found to be possible: 35 patients (73%) with mild and 13 patients (27%) with severe acute pancreatitis. The overall success rate was 79% (38 of 48 patients), with 85% (30 of 35 patients) and 62% (8 of 13 patients) having mild and severe disease, respectively. Median duration of time between onset of symptoms and surgery was 10 days (range, 4–19 days) in edematous and 14 days (range, 7–29 days) in necrotizing pancreatitis (p= 0.0353). Operating time (median, 80 min) and hospital stay (median, 5 days) were almost the same in both groups. Total morbidity was 8%, with no mortality. Conclusions: Laparoscopic cholecystectomy with preoperative endoscopic common bile duct clearance is recommended as a treatment of choice for biliary acute pancreatitis. In mild disease, this is performed safely within 7 days, whereas in severe disease, especially in extended pancreatic necrosis, at least 3 weeks should elapse because of an increased infection risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649901175
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  • 8
    Electronic Resource
    Electronic Resource
    Comparison of different techniques for detection of cytomegalovirus infection following bone marrow transplantation (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 595-600 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 317 different clinical samples obtained from patients following bone marrow transplantation and 56 blood and urine samples from seronegative control persons were screened for the presence of human cytomegalovirus (CMV) using virus culture and slot-blot hybridization. Immunohistochemical techniques using monoclonal antibodies to various viral antigens and in situ hybridization techniques were also utilised for detection of CMV in tissue samples. In cell suspensions of blood, bone marrow and effusions, and in liver biopsies, CMV DNA could be demonstrated more often by slot-blot and in situ hybridization techniques than by virus culture or immunostaining of viral antigens. For detection of CMV in lung biopsies and other clinical samples containing mainly cell-free virus, such as urine, bronchial lavage and throat washings, virus culture was found to be at least as sensitive as the hybridization techniques. Immunostaining proved to be a fast and sensitive technique for detection of CMV in tissues and may thus provide additional information about viral replication and clinical relevance of the virus infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967214
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  • 9
    Electronic Resource
    Electronic Resource
    Correlation of interstitial pneumonia with human cytomegalovirus-induced lung infection and graft-versus-host disease after bone marrow transplantation (1995)
    Springer
    Medical microbiology and immunology 184 (1995), S. 115-121 
    Details
    ISSN: 1432-1831
    Keywords: Cytomegalovirus (CMV) ; Pneumonitis ; Graft-versus-host disease (GvHD) ; Bone marrow transplantation (BMT)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a retrospective analysis lung biopsy specimens obtained postmortem from 30 consecutive allogeneic bone marrow transplant recipients who had died of either interstitial pneumonitis (IP; 18/30 patients) or various other causes (12/30 patients) were studied for the local presence of human cytomegalovirus (HCMV) by culture, in situ hybridization, polymerase chain reaction (PCR) and immunohistochemistry for HCMV proteins. All patients suffering from IP were found to be HCMV positive in the lung biopsy. PCR revealed the highest sensitivity for HCMV detection in lung biopsies, but in 15/18 PCR-positive samples local HCMV infection could be confirmed by at least one additional technique. All the lung biopsies obtained from the 12 patients without IP were negative for HCMV by all techniques applied, except one with a weak HCMV-DNA signal in the PCR assay. The severity of the clinical, as well as histological and immunohistological alterations in the lung did not correlate with the amount of HCMV-DNA or the number of HCMV-positive cells detected in the biopsy. An increase of HLA-class II antigen and of ICAM-1 expression on the alveolar epithelium, as well as presence of activated CD8+ or CD4+ lymphocytes infiltrating only HCMV-positive lung biopsies revealed T cell-mediated immune reactions to be involved in the pathogenesis of IP. Since all analyzed patients presented with severe acute or extensive chronic graft-versus-host disease (GvHD), but only those with pulmonary HCMV infection developed IP, dissemination of HCMV appears to be the primary requirement for the initiation of IP. GvHD, however, may interfere with normal control of subsequent antiviral immune responses and, thus, provoke the immunopathology of IP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224347
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  • 10
    Electronic Resource
    Electronic Resource
    Differential regulation of HLA class I genes by interferon (1990)
    Springer
    Immunogenetics 31 (1990), S. 245-252 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Allele-specific differences in the regulation of HLA class I genes by type I interferon (IFN) were observed after transfection of eight HLA-B,-A, or-C genes into mouse L cells. HLA-B7 and -Bw64 gene expression was significantly more inductible by type I IFN than the genes coding for HLA-B27, HLA-B51, HLA-B38, HLA-B39, HLA-Cw3, and HLA-A2 antigens. Modification of the 5′ end of HLA-B7 and HLA-B27 genes revealed the presence of enhancer sequences responding to IFN treatment in the 5′ untranslated region of HLA-B7, but not of HLA-B27 and suggested further, independently acting enhancer elements downstream of the transciption initiation site. Comparison of 5′ enhancer region sequences in correlation with type I IFN inducibility of the different HLA class I alleles indicated that the exchange of only two nucleotides in the interferon response sequence (IRS) or enhancer A region of HLA-B7 or -Bw64 could account for nonregulated promoters in all other HLA-A,-B or -C alleles analyzed. Thus, type I IFN stimulation of HLA class I genes in mouse L cells appears to predominantly operate in most alleles by a mechanism targeted to enhancer sequences downstream of the gene's transcription initiation site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204896
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