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  • 1
    Digitale Medien
    Digitale Medien
    Behavioral Model of Anorexia Nervosa Characteristics of Young Female Rats with Restricted Feeding in Activity-Wheel Cages (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 575 (1989), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1989.tb53295.x
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  • 2
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    The development of discriminated autonomic and instrumental responses during avoidance conditioning in the Rhesus monkey (1966)
    Provincetown, Mass., etc. : Periodicals Archive Online (PAO)
    The Journal of Genetic Psychology. 108:2 (1966:June) 199 
    Details
    ISSN: 0022-1325
    Thema: Psychologie
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3284-1966-108-02-000003
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  • 3
    Digitale Medien
    Digitale Medien
    Alteration in hypnotic effect of pentobarbital following repeated agonistic confrontations in mice (1989)
    Springer
    Psychopharmacology 97 (1989), S. 30-34 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Pentobarbital hypnosis ; Naloxone ; Defeat ; Attack ; Mice
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We investigated how repeated agonistic confrontations affect the hypnotic effect of pentobarbital (PB) in male mice, using a resident-intruder paradigm. PB concentrations in the cortex, midbrain and brainstem were determined. Agonistic confrontations were terminated after 10 or 20 attack bites, and were repeated for 5 consecutive days. Immediately after the last encounter, PB (55 mg/kg, IP) was administered to both resident and intruder mice. Compared to the control group, intruders exposed to 20 daily attack bites showed a significant prolongation of the latency to sleep and a shortening of the duration of sleeping time. At the stage of induction, no significant difference in brain PB levels was found between the “defeated” and control intruders. At the stage of recovery, however, the “defeated” intruders showed a significantly low level of PB in all brain areas. In contrast, attacking resident mice did not show any significant changes in either the hypnotic effect or regional brain concentration of PB. Because pretreatment with naloxone prior to daily agonistic confrontation antagonized the alteration in PB-induced hypnosis, it seems that endogenous opioid mechanisms may participate in this phenomenon. The present study indicates that susceptibility to a hypnotic drug can be altered by chronic social conflict experience.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00443408
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  • 4
    Digitale Medien
    Digitale Medien
    Acute and chronic effects of psychotropic drugs on maternal aggression in mice (1989)
    Springer
    Psychopharmacology 97 (1989), S. 339-342 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Maternal aggression ; Psychotropic drugs ; Chlordiazepoxide ; Imipramine ; Haloperidol ; Female mice
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The present study investigated the acute and chronic effects of psychotropic drugs on maternal aggression in mice. All female mice had been singly housed since the end of the 4-day mating period. Behavioral testing for acute drug effects was carried out on postpartum days 5 and 7. Chronic drug treatment was started immediately after removal of the partner male, and was terminated on the 3rd postpartum day; behavioral testing was done on the 5th postpartum day. Acute administration of chlordiazepoxide (CDP; 5, 10 and 15 mg/kg, IP) showed a biphasic effect on maternal aggression; 10 mg/kg CDP significantly increased the frequency of bites, while 15 mg/kg CDP significantly decreased it. Imipramine (IMP; 5, 10 and 15 mg/kg, IP) decreased the frequency of bites in a dose-dependent manner. Haloperidol (HAL; 0.1, 0.2 and 0.4 mg/kg, IP) also decreased the frequency of bites dose dependently, but 0.2 and 0.4 mg/kg HAL decreased both the frequency and duration of locomotion. Chronic treatment with either CDP (5 and 10 mg/kg, IP) or HAL (0.1 and 0.2 mg/kg, IP) failed to alter the frequency of bites, while IMP (5 and 10 mg/kg, IP) decreased the frequency of bites. This evidence indicates that the antidepressant imipramine has a specific action in alleviating postpartum female aggression, and suggests that female aggression in mice is a useful tool for differentiating the actions of psychtropic drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00439447
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  • 5
    Digitale Medien
    Digitale Medien
    The effects of a new benzodiazepine derivative, ID-540, on the averaged photopalpebral reflex in man (1978)
    Springer
    Psychopharmacology 58 (1978), S. 217-222 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Anxiolytic drugs ; Photopalpebral reflex ; Benzodiazepines ; Clinical pharmacology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of 7-chloro-5-(2-fluorophenyl)-1-methyl-1 H, 1·4-benzodiazepin-2(3 H)-one (ID-540), a recently introduced benzodiazepine derivative, on the averaged photopalpebral reflex (PPR), subjective symptoms, and serum levels of ID-540 and its principal metabolite, N-desmethyl-ID-540, following an oral dose of 0.5 mg or placebo were investigated in six male Japanese students in a double-blind, crossover design. The peak latencies of PPR showed a statistically significant prolongation, with maximum level at 3h after administration, which recovered to the initial level within 4h. The amplitude of PPR failed to show a definite response to the drug. The serum concentration of ID-540 reached a peak level 2–3h after administration, and then decreased at 4h. N-Desmethyl-ID-540 exhibited a slow, gradual rise in serum. The latencies of PPR were positively correlated with the serum level of ID-540 but not with the N-desmethyl-ID-540. It is concluded that the PPR test may be a useful method for predicting the clinical effects of psychotropic drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00427382
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  • 6
    Digitale Medien
    Digitale Medien
    Effect of recombinant granulocyte colony-stimulating factor (rG-CSF) on chemotherapy-induced neutropenia in patients with urogenital cancer (1991)
    Springer
    Cancer chemotherapy and pharmacology 27 (1991), S. 253-257 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of recombinant granulocyte colony-stimulating factor (rG-CSF) on the myelosuppression, especially neutropenia, induced by cancer chemotherapy in patients with urogenital cancer were investigated in a randomized, controlled clinical study. In this study, rG-CSF was given subcutaneously at a dose of 2 μg/kg per day for 14 consecutive days. Changes in neutrophil counts were compared between the first (no rG-CSF) and second cycles (rG-CSF treatment period) of chemotherapy. rG-CSF administration was found to be effective in reducing the duration of neutropenia, in elevating the neutrophil nadir, and in reducing recovery time. Based on comparisons between the randomized rG-CSF treatment group (with rG-CSF) and the control group, treatment with rG-CSF resulted in the moderation or prevention of neutropenia and the acceleration of recovery. These results demonstrate that in chemotherapy of patients with urogenital cancer, in which neutropenia is a dose- or schedule-limiting factor, the concomitant use of rG-CSF may enable an increase in the dose (higher single dose or increased dose per unit of time) or shorten the chemotherapy period.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00685108
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  • 7
    Digitale Medien
    Digitale Medien
    Prospective and randomized controlled study of chemoembolization therapy in patients with advanced hepatocellular carcinoma (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. S93 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The Cooperative Study Group conducted a study to assess the therapeutic effects of chemoembolization in patients with advanced hepatocellular carcinoma (HCC) using either epirubicin hydrochloride (FARM) or doxorubicin hydrochloride (ADR). A total of 77 patients were enrolled in this study and randomized into 2 groups: 39 patients were treated with a FARM solution as the material for Lipiodol-transcatheter arterial embolization (TAE; FARM group), and 38 patients were treated with an ADR solution as the material for L-TAE (ADR group). For the FARM group, the 1-year survival rate was 69.9% and the 2-year survival rate was 44.5%. For the ADR group, the corresponding survival rates were 74.7% and 44.0%. The differences among the above figures were not statistically significant. As side effects, fever, nausea, and generalized fatigue occurred at almost the same frequencies in the two groups. Changes detected in the liver function and the peripheral blood cell count in both groups were not severe. There was no significant difference between the toxic effects observed in the two groups. In conclusion, there was no significant difference in therapeutic efficacy between the FARM and ADR groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00686676
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  • 8
    Digitale Medien
    Digitale Medien
    Levamisole in postoperative adjuvant immunochemotherapy for gastric cancer (1984)
    Springer
    Cancer immunology immunotherapy 18 (1984), S. 13-18 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The usefulness of LMS in postoperative immunochemotherapy of gastric cancer was investigated. In compliance with the protocol, MMC was given at a dose of 20 mg on the day of gastrectomy, and an additional 10 mg on the next day IV. The patients receiving 600 mg Tegafur daily were then divided into two groups according to whether LMS was also given or not. LMS was administered for 3 days before the operation in a daily dose of 150 mg and for 1 year or more after operation according to a schedule of 3 days' administration followed by an 11-day interval. The 2-year follow-up demonstrated that in stage III patients, the LMS (+) regimen was superior to the LMS (−) regimen, since the former prolonged the relapse-free interval significantly. The survival rate for stage III disease was also significantly higher in the LMS (+) than in the LMS (−) group. There was no significant difference in the incidence of subjective or objective side-effects between two groups. The incidence of agranulocytosis was comparable in the two groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00205393
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  • 9
    Digitale Medien
    Digitale Medien
    A randomized trial of chemoimmunotherapy of acute nonlymphocytic leukemia in adults using a protein-bound polysaccharide preparation (1984)
    Springer
    Cancer immunology immunotherapy 18 (1984), S. 149-154 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of immunotherapy with a protein-bound polysaccharide preparation termed PSK on remission duration and survival of adults with acute nonlymphocytic leukemia (ANLL) was studied in a prospective randomized cooperative trial. After having achieved complete remission and receiving a consolidation therapy, 73 patients were randomized either to maintenance chemotherapy or to maintenance chemotherapy plus immunotherapy with PSK. Ultimately 36 patients in the chemotherapy group and 31 in the chemoimmunotherapy group were evaluable. Six months after the last entry, immunotherapy with PSK showed a borderline beneficial effect on remission duration (P=0.089) and on duration of survival (P=0.062). When the data were analyzed 12, 18, and 24 months after the last entry there were no significant differences in duration of remission and survival between the two groups. However, analysis of the data of patients who had maintained complete remission for more than 270 days revealed that immunotherapy had a suggestive beneficial effect (P=0.105), prolonging the 50% remission period by 418 days (885 vs 467 days). Thus, immunotherapy with PSK seems to be active in the treatment of adult ANLL when used for maintenance therapy in combination with chemotherapy, especially in patients with a good prognosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00205503
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  • 10
    Digitale Medien
    Digitale Medien
    Immunotherapy with bestatin for acute nonlymphocytic leukemia in adults (1986)
    Springer
    Cancer immunology immunotherapy 23 (1986), S. 5-10 
    Details
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a cooperative randomized control study of immunotherapy with bestatin in combination with chemotherapy in adults with acute nonlymphocytic leukemia (ANLL), 101 patients (48 in the bestatin group and 53 in the control group) out of 115 patients registered were evaluated as eligible. The bestatin group achieved a statistically significant prolongation of survival compared with the control group in overall ANLL and acute myelogenous leukemia. In the analysis of patient age, the bestatin group achieved a statistically significant prolongation of both the remission duration and survival in patients aged 50 to 65 years, while the differences were not significant in the 15 to 49 age group. The bestatin group tended to achieve a higher rate of reinduction of remission in patients who had recurrence of leukemia. Side effects developed in only 5 (9.6%) of 52 patients treated with bestatin. None of these side effects were particularly serious in nature. It is concluded that bestatin is useful for prolongation of survival of adult patients with ANLL, making for a longer remission duration especially in elderly patients and with few side effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00205548
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