ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The intensity of sound-induced convulsions in the genetically epilepsy-prone rat (GEPR) was reduced in a dose related fashion by intracerebroventricular administration of dobutamine, (β1 agonist), terbutaline (β2 agonist) or phenylephrine (α1 agonist). BHT-920 (α2 agonist) did not cause a dose-related decrease in sound-induced convulsion intensity. Binding studies showed that whole brain α and β receptor densities (Bmax) were normal while the Kd was increased for the β ligand in GEPR brain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01959107
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