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Evaluation of monoaminergic receptors in the genetically epilepsy prone rat (1984)

Ko, K. H. ; Dailey, J. W. ; Jobe, P. C.

Springer

Cellular and molecular life sciences 40 (1984), S. 70-73

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The intensity of sound-induced convulsions in the genetically epilepsy-prone rat (GEPR) was reduced in a dose related fashion by intracerebroventricular administration of dobutamine, (β1 agonist), terbutaline (β2 agonist) or phenylephrine (α1 agonist). BHT-920 (α2 agonist) did not cause a dose-related decrease in sound-induced convulsion intensity. Binding studies showed that whole brain α and β receptor densities (Bmax) were normal while the Kd was increased for the β ligand in GEPR brain.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01959107

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