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  • 1
    Electronic Resource
    Electronic Resource
    Die T3-Hyperthyreose unter den Aspekten der Sekretion und peripheren Produktion der Schilddrüsenhormone (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 495-500 
    Details
    ISSN: 1432-1440
    Keywords: T3-hyperthyroidism ; Endogenous labelling of T4 and T3 ; T4-deiodination ; T3-production ; r-T3-formation ; T3-Hyperthyreose ; Endogene Markierung von T4 und T3 ; T4-Dejodination ; T3-Produktion ; r-T3-Bildung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der T3-Hyperthyreose ist im Vergleich zu der T4/T3-Hyperthyreose nur das T3 erhöht, während das T4 und das r-T3 im Normbereich liegen. Die endogene Markierung des T4 ist auch bei der T3-Hyperthyreose erhöht, so daß eine vermehrte T4-Sekretion angenommen werden muß. Die normalen T4-Konzentrationen dürften aus einer verstärkten T4-Dejodination resultieren. Als Ursache für das hohe T3 bei gleichzeitig normalem r-T3 wird eine Richtungsumkehr der Dejodination des T4 zum T3 zu ungunsten des r-T3 diskutiert.
    Notes: Summary In contrast to T4/T3-hyperthyroidism, where T4, T3, and r-T3 serum concentrations (SC) are elevated, in T3-hyperthyroidism the T3-SC alone is increased, whereas T4-SC is normal and r-T3 may be decreased. Endogenous labelling of T4 with131I is increased in T3-hyperthyroidism similarly as in T4/T3-hyperthyroidism, clearly reflecting an increased thyroidal formation of T4 in T3-hyperthyroidism. The contradiction of a normal SC of T4 in the presence of enhanced thyroidal formation of T4 may be explained by increased peripheral T4-deiodination. Since in T3-hyperthyroidism T3-SC are elevated whereas r-T3-SC are decreased, there is good evidence for a shift in T4 conversion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696211
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  • 2
    Electronic Resource
    Electronic Resource
    Semisynthetic human insulin and purified pork insulin do not differ in their biological potency (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 1145-1150 
    Details
    ISSN: 1432-1440
    Keywords: Semisynthetic human insulin ; Biological potency ; Insulin hypoglycaemia ; Euglycaemic clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The biological potency of semisynthetic human insulin (Actrapid HM, Novo) and purified pork insulin (Actrapid MC, Novo) was assessed in normal and diabetic subjects. The blood glucose lowering effect and the related counter-regulatory response were initially tested in six healthy subjects who received an i.v. injection of 0.15 U/kg body weight of either insulin preparation. The attained insulin levels were very similar (peak at 15 min: HM 139±7, MC 129±7 µU/ml), as well as the resulting blood glucose curves. A prolonged suppression of C-peptide values was observed after injecting both preparations. The evoked counter-regulatory response [glucagon, growth hormone (GH), cortisol and catecholamines] showed minimal differences. Prolactin secretion was almost identical after HM and MC injection. A glucose clamp study was subsequently performed in six insulin-dependent diabetic (IDD) patients. Blood glucose levels were maintained at 80 mg/dl by the artificial pancreas during a 180 min infusion of MC or HM insulin (30 mU/kg/h). The amounts of dextrose infused during the last 60 min of the study were not significantly different (121±14 vs 137±11 mg/kg/h for MC and HM, respectively). It is clear from our results that at the dose levels used in this study, the biological potency of i.v. injected HM is very similar to that of MC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712180
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  • 3
    Electronic Resource
    Electronic Resource
    Impaired blood pressure response to norepinephrine in a case of insulin-dependent diabetes mellitus — Improvement with a β-adrenergic antagonist (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 366-370 
    Details
    ISSN: 1432-1440
    Keywords: Diabetic neuropathy ; Adrenergic receptors ; Orthostatic hypotension ; β-Blocking agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of juvenile-onset insulin-dependent diabetes mellitus in a 30-year-old male patient is reported. He was admitted to the hospital because of severe diabetic neuropathy, predominantly in the lower extremities. Signs of autonomic neuropathy were not evident but the patient had severe orthostatic hypotension. Circulating catecholamine concentrations were normal; however, the blood pressure response to infused norepinephrine was reduced ten-fold compared to a group of normals. An improvement of the blood pressure response to sympathomimetic drugs was accomplished during the simultaneous administration of propranolol, a β-receptor blocking agent. The present data suggest a possible defect of the adrenergic receptor system in response to sympathomimetic drugs while the release of catecholamines and the function of the parasympathetic nervous system appears to be intact. Treatment with β-blocking agents such as propranolol as an adjunct to sympathomimetics seems to be a promising approach which might deserve further consideration in similar cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716256
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of neurotransmitters on the release of corticotropin releasing hormone (CRH) by rat hypothalamic tissue in vitro (1980)
    Springer
    Experimental brain research 39 (1980), S. 229-234 
    Details
    ISSN: 1432-1106
    Keywords: Hypothalamus in vitro ; CRH ; Neurotransmitters ; Norepinephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of neurotransmitters on in vitro release of CRH from rat hypothalamic tissue were investigated. Three whole hypothalami or three mediobasal hypothalami from male rats, adrenalectomized 7 days before, were incubated for 10 min in a medium similar to cerebrospinal fluid at 37 ° C under 95% O2, 5% CO2. CRH activity was assayed by radioimmunological measurement of ACTH released by isolated pituitary cells from adrenalectomized rats. Norepinephrine (NE) at a concentration of 0.02×10−6 M to 2×10−6 M stimulated dose-related CRH release. At larger concentrations the response decreased again (bell-shaped dose-response relationship). The action of norepinephrine was completely blocked by coincubation with phentolamine. Similar results were obtained whether whole hypothalami or mediobasal hypothalami were incubated with norepinephrine. This suggests that the site of action of NE was within the mediobasal hypothalamus. The possibility that the observed effects were due to the CRH-like activity of vasopressin released from the hypothalamic tissue was excluded by simultaneous measurements of CRH activity and arginine-vasopressin concentrations in the medium. Dopamine at very large concentrations (17.6×10−6 M) also stimulated CRH release. Acetylcholine, serotonin, histamine and GABA did not influence the basal CRH release at any of the concentrations tested. These results suggest that in the rat, norepinephrine may have a physiological role as stimulator of CRH-release at the level of the mediobasal hypothalamus. However, in view of the conflicting results obtained with similar and other methods, no definite conclusions should yet be drawn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237553
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  • 5
    Electronic Resource
    Electronic Resource
    Modulation of post-prandial insulin release by ingested opiate-like substances in dogs (1983)
    Springer
    Diabetologia 24 (1983), S. 113-116 
    Details
    ISSN: 1432-0428
    Keywords: β-Casomorphin ; enkephalin ; naloxone ; insulin release ; exorphins ; opiates ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have previously demonstrated that opiate-like substances in food protein (exorphins), contained in the peptic digest of gluten, stimulate insulin and glucagon release in dogs and that this effect is inhibited by the opiate antagonist naloxone. The present study was designed to evaluate the possible rôle of ingested opiate-like substances in the modulation of post-prandial insulin release. Similarly, the addition of synthetic β-casomorphins, which are the opioid-active material of bovine casein peptone, elicit a stimulation of post-prandial insulin release during a liver extract-sucrose test meal. The addition of met-enkephalin to a liver extract-sucrose test meal also augmented the post-prandial insulin response. Both stimulatory effects were reversed by oral naloxone, as was the post-prandial increase of insulin following ingestion of bovine casein peptone (casopeptone). The post-prandial insulin response to digested and undigested liver extract was not affected by naloxone, suggesting that the foregoing effects are likely to be specific to opiate-like materials contained in foodstuff (exorphins). In view of previous findings, the present data are compatible with a role of opiate-like substances contained in ingested nutrients in the regulation of post-prandial insulin secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297392
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of synthetic rat C-peptide in normal and diabetic rats (1983)
    Springer
    Diabetologia 25 (1983), S. 288-290 
    Details
    ISSN: 1432-0428
    Keywords: C-peptide ; insulin secretion ; effect of insulin ; alloxan-diabetic rats ; C-peptide effect in vivo ; somatostatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of synthetic rat C-peptide 1 and C-peptide 2 on plasma insulin and blood glucose concentrations in the rat were studied. Infusion of rat C-peptide (500μg·h-1· kg-1) diminished glucose induced increase of plasma insulin by 56% (15.2±0.9 versus 6.6± 0.6 ng/ml, p〈0.01, mean±SEM). Somatostatin infused at a rate of 50 μg·h-1·kg-1 body weight inhibited glucose-induced insulin secretion by 33%. In the presence of a mixture of both C-peptides or somatostatin, blood glucose after intravenous glucose was higher than in the control experiments. In alloxan-diabetic rats, C-peptide (160 μg/kg) significantly increased and prolonged the hypoglycaemic effect of exogenous insulin. It is suggested that C-peptide may not be a biologically inert substance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279945
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  • 7
    Electronic Resource
    Electronic Resource
    Nucleated blood cells both bind and internalize insulin (1983)
    Springer
    Diabetologia 24 (1983), S. 69-70 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275951
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  • 8
    Electronic Resource
    Electronic Resource
    Report of the Third Workshop of the EASD Study Group on Artificial Insulin Delivery Systems, Pancreas and Islet Transplantation (AIDSPIT) (1984)
    Springer
    Diabetologia 27 (1984), S. 607-608 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276979
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  • 9
    Electronic Resource
    Electronic Resource
    Book reviews (1980)
    Springer
    Diabetologia 19 (1980), S. 406-408 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280531
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  • 10
    Electronic Resource
    Electronic Resource
    Somatostatinoma syndrome. Clinical, morphological and metabolic features and therapeutic aspects (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 681-689 
    Details
    ISSN: 1432-1440
    Keywords: Somatostatin ; Insulin ; C-peptide ; Diabetes ; Pituitary function ; Gastric acid secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of somatostatinoma syndrome in a 30-year-old woman is presented. Basal levels of growth hormone and of pancreatic and gastric hormones were reduced and the response of growth hormone, insulin and C-peptide to stimuli such as arginine, glucose, glibenclamide and calcium was virtually abolished. Similarly, gastric acid secretion, pancreatic exocrine function and intestinal absorption were significantly reduced. On the other hand, basal and stimulated levels of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) were within the normal range. Plasma somatostatin-like immunoreactivity was increased to 600 2,000 pg/ml (normal: 88–140 pg/ml). Immunocytochemical studies demonstrated the presence of somatostatin immunoreactive material in the primary tumour in the head of the pancreas and in the liver metastases. In spite of two courses of chemotherapy with streptozotocin and 5-fluorouracil the patient died due to liver failure 5 months after the first admission to hospital.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487613
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