ISSN:
1432-2072
Keywords:
Thermoregulation
;
Acetylcholine
;
Muscarinic
;
Serotonin
;
Interaction
;
Alaproclate
;
Oxotremorine
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Stimulation of muscarinic cholinergic receptors with the highly potent and selective receptor agonist oxotremorine produced hypothermia in rats. Alaproclate, a purported selective serotonergic reuptake inhibitor, potentiated this response. Destruction of central presynaptic serotonergic terminals with the potent cytotoxin p-chloroamphetamine (PCA) failed to attenuate the hypothermic response to oxotremorine in alaproclate-pretreated animals. These results could be taken to suggest that alaproclate may act, at least in part, via a non-serotonergic mechanism to potentiate the oxotremorine-induced hypothermic response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00443412
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